scholarly journals T2-based arterial spin labeling measurements of blood to tissue water transfer in human brain

2012 ◽  
Vol 37 (2) ◽  
pp. 332-342 ◽  
Author(s):  
Johannes Gregori ◽  
Norbert Schuff ◽  
Rolf Kern ◽  
Matthias Günther
Keyword(s):  
Human Brain ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Water Transfer ◽  
Tissue Water

scholarly journals Functional localization in the human brain: Gradient-echo, spin-echo, and arterial spin-labeling fMRI compared with neuronavigated TMS

2011 ◽  
Vol 32 (3) ◽  
pp. 341-357 ◽  
Author(s):  
Svenja Diekhoff ◽  
Kamil Uludağ ◽  
Roland Sparing ◽  
Marc Tittgemeyer ◽  
Mustafa Cavuşoğlu ◽  
...  
Keyword(s):  
Human Brain ◽  
Arterial Spin Labeling ◽  
Spin Echo ◽  
Spin Labeling ◽  
Gradient Echo ◽  
Functional Localization

scholarly journals Human Brain: Reliability and Reproducibility of Pulsed Arterial Spin-labeling Perfusion MR Imaging

Radiology ◽  
2005 ◽  
Vol 234 (3) ◽  
pp. 909-916 ◽  
Author(s):  
Geon-Ho Jahng ◽  
Enmin Song ◽  
Xiao-Ping Zhu ◽  
Gerald B. Matson ◽  
Michael W. Weiner ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Human Brain ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Perfusion Mr ◽  
Perfusion Mr Imaging

scholarly journals Combined Arterial Spin Labeling and Diffusion-Weighted Imaging for Noninvasive Estimation of Capillary Volume Fraction and Permeability-Surface Product in the Human Brain

2012 ◽  
Vol 33 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Patrick W Hales ◽  
Chris A Clark
Keyword(s):  
Human Brain ◽  
Diffusion Weighted Imaging ◽  
Arterial Spin Labeling ◽  
Volume Fraction ◽  
A Priori ◽  
Spin Labeling ◽  
Gaussian Kernel ◽  
Diffusion Weighted ◽  
Permeability Surface ◽  
Surface Product

A number of two-compartment models have been developed for the analysis of arterial spin labeling (ASL) data, from which both cerebral blood flow ( CBF) and capillary permeability-surface product ( PS) can be estimated. To derive values of PS, the volume fraction of the ASL signal arising from the intravascular space ( vbw) must be known a priori. We examined the use of diffusion-weighted imaging (DWI) and subsequent analysis using the intravoxel incoherent motion model to determine vbw in the human brain. These data were then used in a two-compartment ASL model to estimate PS. Imaging was performed in 10 healthy adult subjects, and repeated in five subjects to test reproducibility. In gray matter (excluding large arteries), mean voxel-wise vbw was 2.3 ± 0.2 mL blood/100 g tissue (all subjects mean ± s.d.), and CBF and PS were 44 ± 5 and 108 ± 2 mL per 100 g per minute, respectively. After spatial smoothing using a 6-mm full width at half maximum Gaussian kernel, the coefficient of repeatability of CBF, vbw and PS were 8 mL per 100 g per minute, 0.4 mL blood/100 g tissue, and 13 mL per 100 g per minute, respectively. Our results show that the combined use of ASL and DWI can provide a new, noninvasive methodology for estimating vbw and PS directly, with reproducibility that is sufficient for clinical use.

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