scholarly journals Gd-EOB-DTPA-enhanced MR imaging: Prediction of hepatic fibrosis stages using liver contrast enhancement index and liver-to-spleen volumetric ratio

2012 ◽  
Vol 36 (5) ◽  
pp. 1148-1153 ◽  
Author(s):  
Satoshi Goshima ◽  
Masayuki Kanematsu ◽  
Haruo Watanabe ◽  
Hiroshi Kondo ◽  
Hiroshi Kawada ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Enhancement ◽  
Hepatic Fibrosis

Yolk–shell magnetic composite Fe3O4@Co/Zn-ZIF for MR imaging-guided chemotherapy of tumors in vivo

2021 ◽  
Author(s):  
Ying Li ◽  
Lu-Lu Jiang ◽  
Ya-Xian Qiao ◽  
Dong Wan ◽  
Yan-Feng Huang
Keyword(s):  
Mr Imaging ◽  
Contrast Enhancement ◽  
Magnetic Composite ◽  
Loading Capacity ◽  
Ph Responsive

The yolk–shell composites Fe3O4@Co/Zn-ZIF exhibited high doxorubicin loading capacity, pH-responsive release characteristics, and strong T2-weighted MR imaging contrast enhancement, and were used for MR imaging-guided chemotherapy of tumors in vivo.

Comparison of the Safety of Standard and Triple Dose Gadodiamide Injection in MR Imaging of the Central Nervous System

1994 ◽  
Vol 35 (4) ◽  
pp. 396-399 ◽  
Author(s):  
M. G. Svaland ◽  
T. Christensen ◽  
E. Lundorf
Keyword(s):  
Mr Imaging ◽  
Adverse Events ◽  
Contrast Enhancement ◽  
Dose Group ◽  
Serum Bilirubin ◽  
Diagnostic Yield ◽  
Blood Chemistry ◽  
New Information ◽  
Safety Parameters ◽  
The Central Nervous System

Gadodiamide injection was administered intravenously to 49 patients with known or suspected CNS lesions undergoing MR imaging. Two parallel groups were used to evaluate the efficacy and safety of single doses of 0.1 (25 patients) and 0.3 (24 patients) mmol/kg b.w. The principal measures of efficacy were diagnostic yield of MR and the overall contrast enhancement. Adverse events and serum bilirubin were the main safety parameters. Contrast enhancement of the lesion was observed for 16 patients in each dose group. Thirteen patients in the 0.1 and 17 in the 0.3 mmol/kg group had their diagnosis amended following the postcontrast image, but only one patient in each dose group had their management affected by new information from the postcontrast image. The overall diagnostic utility of gadodiamide injection was good, but there were no differences between the 2 doses studied in this respect. No injection-associated discomfort or other adverse events were reported. No clinically important changes in serum bilirubin, or other parameters of blood chemistry, or hematology were observed. Overall, the safety profile of gadodiamide injection 0.3 mmol/kg b.w. in this study was similar to that of 0.1 mmol/kg b.w.

Confluent hepatic fibrosis in cirrhosis: ferumoxides-enhanced MR imaging findings

2001 ◽  
Vol 26 (2) ◽  
pp. 146-148 ◽  
Author(s):  
M. Matsuo ◽  
M. Kanematsu ◽  
H. Kondo ◽  
T. Asano ◽  
H. Tomimatsu ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Hepatic Fibrosis ◽  
Imaging Findings

scholarly journals Influence of hepatic fibrosis and inflammation: Correlation between histopathological changes and Gd-EOB-DTPA-enhanced MR imaging

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0215752 ◽  
Author(s):  
N. Verloh ◽  
U. Probst ◽  
K. Utpatel ◽  
F Zeman ◽  
F. Brennfleck ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Hepatic Fibrosis ◽  
Histopathological Changes

Confluent hepatic fibrosis in advanced cirrhosis: evaluation with MR imaging.

Radiology ◽  
1993 ◽  
Vol 189 (3) ◽  
pp. 871-874 ◽  
Author(s):  
K Ohtomo ◽  
R L Baron ◽  
G D Dodd ◽  
M P Federle ◽  
Y Ohtomo ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Hepatic Fibrosis ◽  
Advanced Cirrhosis

scholarly journals Intracranial Gliomas: Association between MRI Features and Tumor Grade

2019 ◽  
Vol 8 (2) ◽  
pp. 93-99
Author(s):  
Md Rokibul Islam ◽  
KM Tarikul Islam ◽  
Moshiur Rahman ◽  
Mohammad Hossain ◽  
Raziul Haque ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Enhancement ◽  
Predictive Value ◽  
Tumor Grade ◽  
Mass Effect ◽  
Low Grade ◽  
Imaging Features ◽  
Peritumoral Edema ◽  
Cross Sectional ◽  
Mri Features

Purpose: Intracranial gliomas are not uncommon in our country. The therapeutic management and prognosis in patients with gliomas depend on the reliable distinction between high and low-grade gliomas. The purpose of the present study was to determine whether any association exists between various individual MR imaging features and histopathologically determined tumor grade of intracranial gliomas. Our target was to explore whether MRI could enable correct determination the grading of gliomas which will help early diagnosis, staging, grade assessing, determining the appropriate treatment, preoperative planning for surgical resection and post operative management plan. Materials and Methods: It was a cross sectional type of observational study. This study was conducted on 44 cases of intracranial gliomas. Only patients having histopathologically proven intracranial gliomas who underwent surgery or stereotactic biopsy were considered as a study population. Results: The present study revealed that there is significant association between the MR imaging features and histopathological grading of intracranial gliomas. Contrast enhancement in MRI showed most significant (p<0.001). Other significant MR imaging features were peritumoral edema (p=0.001), tumor border definition (p=0.001), necrosis or cystic change of tumor (p=0.001) and mass effect (p=0.003). In this study preoperative MRI diagnosis was correct in 39 patients with accuracy of 88.6%. Sensitivity, specificity, positive predictive value and negative predictive value of MRI in detecting tumor grade were 86.4%, 90.9%, 90.5% and 87% respectively. Conclusion: MRI is sensitive, specific and accurate in assessing the grade of gliomas. Contrast enhancement is the most important predictor. Peritumoral edema, tumor border definition, mass effect and necrosis/cystic changes of tumor are also important indicators of tumor grade. Bang. J Neurosurgery 2019; 8(2): 93-99

scholarly journals Gd(iii)–Pt(iv) theranostic contrast agents for tandem MR imaging and chemotherapy

2020 ◽  
Vol 11 (9) ◽  
pp. 2524-2530 ◽  
Author(s):  
Casey J. Adams ◽  
Thomas J. Meade
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Contrast Enhancement ◽  
Theranostic Agents

The first example of Gd(iii)–Pt(iv) theranostic agents that are intracellularly reduced to provide MR contrast enhancement with simultaneous Pt(ii) chemotherapy.

scholarly journals Brainstem glioma: Prediction of histopathologic grade based on conventional MR imaging

2017 ◽  
Vol 31 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Yashar Moharamzad ◽  
Morteza Sanei Taheri ◽  
Farhad Niaghi ◽  
Elham Shobeiri
Keyword(s):  
Logistic Regression ◽  
Mr Imaging ◽  
Contrast Enhancement ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Low Grade ◽  
Imaging Features ◽  
High Grade ◽  
Post Contrast ◽  
Mri Features

Objective The objective of this article is to investigate the association between specific MR imaging findings and histopathologic grading (low-grade vs. high-grade) of brainstem gliomas (BSGs). Methods Sixty-two males and 34 females (mean (standard deviation, SD) age of 24.61 (17.20) years, range = 3 to 70 years) with histologically diagnosed BSG underwent conventional 1.5 T MR imaging, which included T1-weighted (T1W), T2W, and post-contrast T1W sequences. There were 39 children (mean age of 9.38 years) and 57 adults (mean age of 35 years). A binary logistic regression analysis was used to explore associations between MRI features and histopathological grade of the BSG. Results Binary logistic regression revealed that necrosis (adjusted odds ratio (OR) = 16.07; 95% confidence interval (CI) = 3.20 to 80.52; p = 0.001) and inhomogeneous contrast enhancement (adjusted OR = 8.04; 95% CI = 1.73 to 37.41; p = 0.008) as significant predictors of high-grade BSG. The equation (Nagelkerke R2 = 0.575) is Logit ( p high-grade BSG) = (2.77 × necrosis) + (2.08 × heterogeneous contrast enhancement) – 3.13. Sensitivity and specificity values were respectively 66.7% and 96.0% for necrosis and 85.7% and 65.9% for inhomogeneous contrast-enhancing lesions. In the pediatric age group, only inhomogeneous contrast enhancement (adjusted OR = 40; 95% CI = 3.95 to 445.73; p = 0.002) was a significant predictor for high-grade BSG. Conclusion Conventional MR imaging features such as necrosis and inhomogeneous contrast enhancement in adults and heterogeneous contrast enhancement in children suggest high-grade BSG.

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