scholarly journals MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA

2012 ◽  
Vol 36 (3) ◽  
pp. 664-671 ◽  
Author(s):  
Akihiro Nishie ◽  
Yoshiki Asayama ◽  
Kousei Ishigami ◽  
Tsuyoshi Tajima ◽  
Daisuke Kakihara ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Fibrosis ◽  
Contrast Agent ◽  
Superparamagnetic Iron Oxide ◽  
Liver Specific Contrast Agent

scholarly journals Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14051-14059
Author(s):  
Abdulrahman Ahmed Mahmood ◽  
Jianqi Zhang ◽  
Rufang Liao ◽  
Xiwei Pan ◽  
Dan Xu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Cancer ◽  
Contrast Agent ◽  
Cancer Diagnosis ◽  
Liver Tumors ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agent ◽  
Potential Toxicity ◽  
Mri Contrast ◽  
Specific Enhancement

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.

Radiology ◽  
1988 ◽  
Vol 168 (2) ◽  
pp. 297-301 ◽  
Author(s):  
D D Stark ◽  
R Weissleder ◽  
G Elizondo ◽  
P F Hahn ◽  
S Saini ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Clinical Application ◽  
Superparamagnetic Iron Oxide

Experimental Study of Ultrafine Superparamagnetic Iron Oxide-Enhanced MRI in an Atherosclerotic Plaque Model

2020 ◽  
Vol 20 (12) ◽  
pp. 7444-7450
Author(s):  
Xinjian Chen ◽  
Xia Li ◽  
Qiong Chen
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Superparamagnetic Iron Oxide ◽  
Pathological Examination ◽  
Specific Marker ◽  
High Fat ◽  
Enhanced Mri ◽  
Before And After ◽  
Experimental Group

Unstable atherosclerotic (AS) plaques contain numerous macrophages that can phagocytose a specific contrast agent, namely ultrafine superparamagnetic iron oxide (USPIO). This study prepared USPIO nanoparticles, defined their physical and magnetic properties and transmission characteristics, explored the feasibility of their use as a magnetic resonance negative contrast agent, and used them to detect unstable AS plaque as a specific marker of macrophages. We randomly divided 20 healthy male New Zealand white rabbits into two groups, experimental and control (n = 10 each). The experimental group was fed pure high-fat feed. The magnetic resonance imaging (MRI) performance of arterial plaque before and after USPIO enhancement compare with pathological results. The experimental group successfully established a rabbit AS plaque model, and 8 of 10 rabbits developed AS plaque. USPIO-enhanced T2W1 sequence showed that the central signal of the plaque was reduced, and the signal-to-noise ratio of the vascular wall was the lowest at 96 h. The control group showed no change in the wall signal before and after enhancement. The USPIO-enhanced PJN2D-TOF sequence showed dotted filling defects on the tube wall. Pathological examination showed that USPIO nanoparticles were mainly deposited under the arterial intima. A simple high-fat diet can establish a rabbit AS plaque model, and USPIO-enhanced MRI reflects the condition of rabbit AS plaque, which is helpful in evaluating AS lesion diagnosis.

Whole tissue AC susceptibility after superparamagnetic iron oxide contrast agent administration in a rat model

2007 ◽  
Vol 311 (1) ◽  
pp. 460-463 ◽  
Author(s):  
Francisco José Lázaro ◽  
Lucía Gutiérrez ◽  
Ana Rosa Abadía ◽  
María Soledad Romero ◽  
Antonio López ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Rat Model ◽  
Ac Susceptibility ◽  
Superparamagnetic Iron Oxide ◽  
Contrast Agent Administration
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