scholarly journals Blood oxygenation level-dependent (BOLD) MRI of human skeletal muscle at 1.5 and 3 T

2012 ◽  
Vol 35 (5) ◽  
pp. 1227-1232 ◽  
Author(s):  
Sasan Partovi ◽  
Anja-Carina Schulte ◽  
Bjoern Jacobi ◽  
Markus Klarhöfer ◽  
Alan B. Lumsden ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Bold Mri ◽  
Blood Oxygenation Level ◽  
Oxygenation Level

scholarly journals Clinical implications of skeletal muscle blood-oxygenation-level-dependent (BOLD) MRI

2012 ◽  
Vol 25 (4) ◽  
pp. 251-261 ◽  
Author(s):  
Sasan Partovi ◽  
Sasan Karimi ◽  
Bjoern Jacobi ◽  
Anja-Carina Schulte ◽  
Markus Aschwanden ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Clinical Implications ◽  
Bold Mri ◽  
Blood Oxygenation Level ◽  
Oxygenation Level

Abstract 2240: T2-Prepared Steady-State Free-Precession Blood Oxygenation Level-Dependent MRI in Patients with Coronary Artery Disease and Normal Volunteers: Validation against PET

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Theodoros D Karamitsos ◽  
Alejandro Recio-Mayoral ◽  
Jayanth R Arnold ◽  
Lucia Leccisotti ◽  
Paul Bhamra-Ariza ◽  
...  
Keyword(s):  
Gold Standard ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Short Axis ◽  
Normal Volunteers ◽  
Bold Mri ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
Artery Disease ◽  
Perfusion Measurements

Blood oxygenation level-dependent (BOLD) MRI clinical studies at 1.5 Tesla (T) have been principally limited by low signal to noise. We sought to apply this method at 3T in patients with coronary artery disease (CAD) and normal volunteers, and validated it against perfusion measurements by PET. Twenty-two patients (age 62±8 yrs, 16 men) with CAD (at least 1 stenosis > 50% on quantitative coronary angiography-QCA) and 10 normal volunteers (age 52±7 yrs, 7 men) underwent 3T BOLD MRI and PET. For BOLD MRI a mid-ventricular slice was acquired every 30sec at rest and during adenosine stress (140 μg/kg/min). A set of 6 images was acquired at rest and at peak stress. Using PET with oxygen-15 labelled water, myocardial blood flow (MBF) was measured at baseline and during adenosine hyperemia. The BOLD short-axis view was divided into 6 segments, according to the mid-ventricular segments of the 17-AHA segment model, and mean signal intensities (SI) were calculated using QMass (Medis) software. PET images were analyzed with MATLAB software (MathWorks Inc.) and registered with the BOLD short-axis image using anatomical landmarks. Taking QCA as the gold standard, cut-off values for stress MBF (< 2.57ml/min/g - AUC 0.79) and BOLD SI change (< 4.75% -AUC 0.78) were determined to define ischemic segments. Rest MBF, stress MBF, coronary flow reserve and BOLD-SI change of ischemic (n=69), remote to ischemia (n=73) and normal segments (n=60) are shown in table . BOLD MRI and PET agreed on the presence or absence of ischemia in 18 of the 22 patients (82%), and in all normals. With regards to per segment analysis: taking PET as the gold standard and by applying the cut-off values for stress MBF and BOLD SI, BOLD MRI had only moderate sensitivity (61%) but good specificity (88%) for the identification of ischemia. T2-prepared SSFP 3T BOLD imaging is feasible in the clinical setting and has good agreement with PET perfusion measurements for the detection of myocardial ischemia.

Blood oxygenation level-dependent MRI at 3T for differentiating prostate cancer from benign tissue: a preliminary experience

2021 ◽  
pp. 20210461
Author(s):  
Yongtae Kim ◽  
Jung Jae Park ◽  
Chan Kyo Kim
Keyword(s):  
Prostate Cancer ◽  
Regional Distribution ◽  
Specific Antigen ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Bold Mri ◽  
Benign Tissue ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
Mean Differences

Objective: Blood oxygenation-level dependent (BOLD) MRI may identify or quantify the regional distribution of hypoxia within a tumor. We aimed to evaluate the feasibility of BOLD MRI at 3 T in differentiating prostate cancer from benign tissue. Methods: A total of 145 patients with biopsy-proven prostate cancer underwent BOLD MRI at 3 T. BOLD MRI was performed using a multiple fast field echo sequence to acquire 12 T2*-weighted images. The R2* value (rate of relaxation, s−1) was measured in the index tumor, and benign peripheral (PZ) and transition zone (TZ), and the results were compared. The variability of R2* measurements was evaluated. Results: Tumor R2* values (25.95 s−1) were significantly different from the benign PZ (27.83 s−1) and benign TZ (21.66 s−1) (p < 0.001). For identifying the tumor, the area under the receiver operating characteristic of R2* was 0.606, with an optimal cut-off value of 22.8 s−1 resulting in 73.8% sensitivity and 52% specificity. In the Bland–Altman test, the mean differences in R2* values were 8.5% for tumors, 13.3% for benign PZ, and 6.8% for benign TZ. No associations between tumor R2* value and Gleason score, age, prostate volume, prostate-specific antigen, or tumor size. Conclusion: BOLD MRI at 3 T appears to be a feasible tool for differentiating between prostate cancer and benign tissue. However, further studies are required for a direct clinical application. Advances in knowledge: The R2* values are significantly different among prostate cancer, benign PZ, and benign TZ.

scholarly journals Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T

2012 ◽  
Vol 25 (12) ◽  
pp. 1321-1330 ◽  
Author(s):  
Rami R. Hallac ◽  
Yao Ding ◽  
Qing Yuan ◽  
Roderick W. McColl ◽  
Jayanthi Lea ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Uterine Cervix ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Bold Mri ◽  
Blood Oxygenation Level ◽  
Oxygenation Level

scholarly journals Noninvasive assessment of kidney dysfunction in children by using blood oxygenation level-dependent MRI and intravoxel incoherent motion diffusion-weighted imaging

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ping Liang ◽  
Yaxian Chen ◽  
ShiChao Li ◽  
Chuou Xu ◽  
Guanjie Yuan ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Bold Mri ◽  
Stage 4 ◽  
Ckd Stage ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
Noninvasive Assessment ◽  
Stage 1

Abstract Objectives To explore whether multiparametric approach including blood oxygenation level-dependent MRI (BOLD-MRI) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can be applied in the assessment of renal function in children with chronic kidney disease (CKD). Materials and methods This prospective study included 74 children (CKD stage 1–3, 51; CKD stage 4–5, 12; healthy volunteers, 11) for renal MRI examinations including coronal T2WI, axial T1WI and T2WI, BOLD-MRI, and DWI sequences. We measured the renal cortex and medulla T2*, ADC, Dt, Dp, and fp values on BOLD and DWI images. Appropriate statistical methods were applied for comparing MRI-derived parameters among the three groups and calculating the correlation coefficients between MRI-derived parameters and clinical data. Receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of MRI-derived parameters. Results There were significant differences in cortex T2*, ADC, Dt, fp and medulla T2*, ADC, Dt among the three groups. Cortex T2*, ADC, Dt, fp and medulla T2*, ADC, Dt had a trend: CKD stage 4–5 < CKD stage 1–3 < healthy volunteers. Cortex and medulla T2*, ADC, Dt were significantly correlated with eGFR, serum creatinine (Scr), cystatin C. In addition, cortex T2* and eGFR showed the highest correlation coefficient (r = 0.824, p < 0.001). Cortex Dt and medulla T2* were optimal parameters for differentiating healthy volunteers and CKD stage 1–3 or CKD stage 4–5 and CKD stage 1–3, respectively. Conclusions BOLD-MRI and IVIM-DWI might be used as a feasible method for noninvasive assessment of renal function in children with CKD.

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