Perfusion parameters analysis of the vertebral bone marrow in patients with Ph1− chronic myeloproliferative neoplasms (PhnegMPN): A dynamic contrast-enhanced MRI (DCE-MRI) study

2011 ◽  
Vol 35 (3) ◽  
pp. 696-702 ◽  
Author(s):  
Nikos Courcoutsakis ◽  
Athina Spanoudaki ◽  
Thomas G. Maris ◽  
Emmanuel Astrinakis ◽  
Emmanuel Spanoudakis ◽  
...  
Keyword(s):  
Myeloproliferative Neoplasms ◽  
Vertebral Bone ◽  
Dce Mri ◽  
Chronic Myeloproliferative Neoplasms ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Vertebral Bone Marrow ◽  
Parameters Analysis ◽  
Mri Study ◽  
Contrast Enhanced Mri

scholarly journals Measurement of perfusion and permeability from dynamic contrast-enhanced MRI in normal and pathological vertebral bone marrow

2010 ◽  
Vol 64 (1) ◽  
pp. 115-124 ◽  
Author(s):  
Andreas Biffar ◽  
Steven Sourbron ◽  
Gerwin Schmidt ◽  
Michael Ingrisch ◽  
Olaf Dietrich ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Vertebral Bone ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Vertebral Bone Marrow ◽  
Contrast Enhanced Mri

scholarly journals Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study

2021 ◽  
Author(s):  
James W. MacKay ◽  
Faezeh Sanaei Nezhad ◽  
Tamam Rifai ◽  
Joshua D. Kaggie ◽  
Josephine H. Naish ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Experimental Medicine ◽  
Sensitivity To Change ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced Mri ◽  
Knee Oa ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Contrast Enhanced Mri

Abstract Objectives Evaluate test-retest repeatability, ability to discriminate between osteoarthritic and healthy participants, and sensitivity to change over 6 months, of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) biomarkers in knee OA. Methods Fourteen individuals aged 40–60 with mild-moderate knee OA and 6 age-matched healthy volunteers (HV) underwent DCE-MRI at 3 T at baseline, 1 month and 6 months. Voxelwise pharmacokinetic modelling of dynamic data was used to calculate DCE-MRI biomarkers including Ktrans and IAUC60. Median DCE-MRI biomarker values were extracted for each participant at each study visit. Synovial segmentation was performed using both manual and semiautomatic methods with calculation of an additional biomarker, the volume of enhancing pannus (VEP). Test-retest repeatability was assessed using intraclass correlation coefficients (ICC). Smallest detectable differences (SDDs) were calculated from test-retest data. Discrimination between OA and HV was assessed via calculation of between-group standardised mean differences (SMD). Responsiveness was assessed via the number of OA participants with changes greater than the SDD at 6 months. Results Ktrans demonstrated the best test-retest repeatability (Ktrans/IAUC60/VEP ICCs 0.90/0.84/0.40, SDDs as % of OA mean 33/71/76%), discrimination between OA and HV (SMDs 0.94/0.54/0.50) and responsiveness (5/1/1 out of 12 OA participants with 6-month change > SDD) when compared to IAUC60 and VEP. Biomarkers derived from semiautomatic segmentation outperformed those derived from manual segmentation across all domains. Conclusions Ktrans demonstrated the best repeatability, discrimination and sensitivity to change suggesting that it is the optimal DCE-MRI biomarker for use in experimental medicine studies. Key Points • Dynamic contrast-enhanced MRI (DCE-MRI) provides quantitative measures of synovitis in knee osteoarthritis which may permit early assessment of efficacy in experimental medicine studies. • This prospective observational study compared DCE-MRI biomarkers across domains relevant to experimental medicine: test-retest repeatability, discriminative validity and sensitivity to change. • The DCE-MRI biomarker Ktransdemonstrated the best performance across all three domains, suggesting that it is the optimal biomarker for use in future interventional studies.

scholarly journals Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: A dynamic contrast-enhanced MRI study

2009 ◽  
Vol 30 (5) ◽  
pp. 1139-1144 ◽  
Author(s):  
Ya-Feng Zhang ◽  
Yi-Xiang J. Wang ◽  
James F. Griffith ◽  
William K.M. Kwong ◽  
Heather T. Ma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Proximal Femur ◽  
Blood Perfusion ◽  
Hypertensive Rats ◽  
Dynamic Contrast Enhanced ◽  
Femur Bone ◽  
Contrast Enhanced ◽  
Mri Study ◽  
Bone Marrow Blood ◽  
Contrast Enhanced Mri

Examining the acute effects of cediranib (RECENTIN, AZD2171) treatment in tumor models: a dynamic contrast-enhanced MRI study using gadopentate

2009 ◽  
Vol 27 (3) ◽  
pp. 377-384 ◽  
Author(s):  
Daniel P. Bradley ◽  
Jean J. Tessier ◽  
Tony Lacey ◽  
Marietta Scott ◽  
Juliane M. Jürgensmeier ◽  
...  
Keyword(s):  
Acute Effects ◽  
Tumor Models ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Mri Study ◽  
Contrast Enhanced Mri

Dynamic contrast enhanced-MRI (DCE-MRI) as a pharmacodynamic biomarker for pazopanib (PZ) in metastatic renal carcinoma (RC).

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e15623-e15623
Author(s):  
Randy F. Sweis ◽  
Milica Medved ◽  
Shannon Towey ◽  
Greg S. Karczmar ◽  
Aytekin Oto ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Contrast Enhanced Mri
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