Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: Data from the osteoarthritis initiative

Hussain Z. Tameem; Siamak Ardekani; Leanne Seeger; Paul Thompson; Usha S. Sinha

doi:10.1002/jmri.22643

Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: Data from the osteoarthritis initiative

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.22643 ◽

2011 ◽

Vol 34 (2) ◽

pp. 372-383 ◽

Cited By ~ 7

Author(s):

Hussain Z. Tameem ◽

Siamak Ardekani ◽

Leanne Seeger ◽

Paul Thompson ◽

Usha S. Sinha

Keyword(s):

Sex Differences ◽

Structure Data ◽

Femoral Cartilage ◽

Osteoarthritis Initiative ◽

Statistical Atlas ◽

Initial Results

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An Atlas-Based Approach to Study Morphological Differences in Human Femoral Cartilage Between Subjects from Incidence and Progression Cohorts: MRI Data from Osteoarthritis Initiative

Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition ◽

10.5772/28410 ◽

2012 ◽

Author(s):

Hussain Tameem ◽

Usha Sinh

Keyword(s):

Femoral Cartilage ◽

Osteoarthritis Initiative ◽

Morphological Differences

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Association of baseline and change in tibial and femoral cartilage thickness and development of widespread full-thickness cartilage loss in knee osteoarthritis – data from the Osteoarthritis Initiative

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2020.03.011 ◽

2020 ◽

Vol 28 (6) ◽

pp. 811-818

Author(s):

M. Dório ◽

D.J. Hunter ◽

J.E. Collins ◽

R. Asher ◽

F. Eckstein ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Cartilage Thickness ◽

Cartilage Loss ◽

Full Thickness ◽

Femoral Cartilage ◽

Osteoarthritis Initiative ◽

Femoral Cartilage Thickness

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Sex-differences of the healthy infra-patellar (Hoffa) fat pad in relation to intermuscular and subcutaneous fat content – Data from the Osteoarthritis Initiative

Annals of Anatomy - Anatomischer Anzeiger ◽

10.1016/j.aanat.2014.12.004 ◽

2015 ◽

Vol 200 ◽

pp. 30-36 ◽

Cited By ~ 16

Author(s):

J. Diepold ◽

A. Ruhdorfer ◽

T. Dannhauer ◽

W. Wirth ◽

E. Steidle ◽

...

Keyword(s):

Sex Differences ◽

Subcutaneous Fat ◽

Fat Content ◽

Fat Pad ◽

Osteoarthritis Initiative

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T2 relaxation time in femoral cartilage changes with radiographic progression of medial knee OA – data from the osteoarthritis initiative

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2019.02.781 ◽

2019 ◽

Vol 27 ◽

pp. S364

Author(s):

S.N. Edd ◽

H. Babel ◽

L.C. Pereira ◽

B.M. Jolles ◽

P. Omoumi ◽

...

Keyword(s):

Relaxation Time ◽

Radiographic Progression ◽

T2 Relaxation Time ◽

T2 Relaxation ◽

Medial Knee ◽

Knee Oa ◽

Femoral Cartilage ◽

Osteoarthritis Initiative

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Longitudinal Femoral Cartilage T2 Relaxation Time and Thickness Changes with Fast Sequential Radiographic Progression of Medial Knee Osteoarthritis—Data from the Osteoarthritis Initiative (OAI)

Journal of Clinical Medicine ◽

10.3390/jcm10061294 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1294

Author(s):

Shannon N. Edd ◽

Patrick Omoumi ◽

Brigitte M. Jolles ◽

Julien Favre

Keyword(s):

Relaxation Time ◽

Lateral Compartment ◽

Medial Compartment ◽

Therapeutic Interventions ◽

T2 Relaxation Time ◽

Inclusion Criteria ◽

T2 Relaxation ◽

Femoral Cartilage ◽

Osteoarthritis Initiative ◽

Early Oa

This study tested for longitudinal changes in femoral cartilage T2 relaxation time and thickness in fast-progressing medial femorotibial osteoarthritis (OA). From the Osteoarthritis Initiative (OAI) database, nineteen knees fulfilled the inclusion criteria, which included medial femorotibial OA and sequential progression from Kellgren–Lawrence grade (KL) 1 to KL2 to KL3 within five years. Median T2 value and mean thickness were calculated for six condylar volumes of interest (VOIs; medial/lateral anterior, central, posterior) and six sub-VOIs (medial/lateral anterior external, central, internal). T2 value and thickness changes between severity timepoints were tested using repeated statistics. T2 values increased between KL1 and KL2 and between KL1 and KL3 in the medial compartment (p ≤ 0.02), whereas both increases and decreases were observed between the same timepoints in the lateral compartment (p ≤ 0.02). Cartilage thickness decreased in VOI/subVOIs of the medial compartment from KL1 to KL2 and KL3 (p ≤ 0.014). Cartilage T2 value and thickness changes varied spatially over the femoral condyles. While all T2 changes occurred in the early radiographic stages of OA, thickness changes occurred primarily in the later stages. These data therefore support the use of T2 relaxation time analyses in methods of detecting disease-related change during early OA, a valuable period for therapeutic interventions.

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