scholarly journals Blood oxygen level-dependent (BOLD) MRI of diabetic nephropathy: Preliminary experience

2011 ◽  
Vol 33 (3) ◽  
pp. 655-660 ◽  
Author(s):  
Zhen J. Wang ◽  
Rahi Kumar ◽  
Suchandrima Banerjee ◽  
Chi-yuan Hsu
Keyword(s):  
Diabetic Nephropathy ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Bold Mri

scholarly journals Measurement of renal tissue oxygenation with blood oxygen level-dependent MRI and oxygen transit modeling

2014 ◽  
Vol 306 (6) ◽  
pp. F579-F587 ◽  
Author(s):  
Jeff L. Zhang ◽  
Glen Morrell ◽  
Henry Rusinek ◽  
Lizette Warner ◽  
Pierre-Hugues Vivier ◽  
...  
Keyword(s):  
Tissue Oxygenation ◽  
Human Subjects ◽  
Blood Oxygen Level Dependent ◽  
Renal Tissue ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Healthy Human ◽  
Bold Mri ◽  
Before And After

Blood oxygen level-dependent (BOLD) MRI data of kidney, while indicative of tissue oxygenation level (Po2), is in fact influenced by multiple confounding factors, such as R2, perfusion, oxygen permeability, and hematocrit. We aim to explore the feasibility of extracting tissue Po2 from renal BOLD data. A method of two steps was proposed: first, a Monte Carlo simulation to estimate blood oxygen saturation (SHb) from BOLD signals, and second, an oxygen transit model to convert SHb to tissue Po2. The proposed method was calibrated and validated with 20 pigs (12 before and after furosemide injection) in which BOLD-derived tissue Po2 was compared with microprobe-measured values. The method was then applied to nine healthy human subjects (age: 25.7 ± 3.0 yr) in whom BOLD was performed before and after furosemide. For the 12 pigs before furosemide injection, the proposed model estimated renal tissue Po2 with errors of 2.3 ± 5.2 mmHg (5.8 ± 13.4%) in cortex and −0.1 ± 4.5 mmHg (1.7 ± 18.1%) in medulla, compared with microprobe measurements. After injection of furosemide, the estimation errors were 6.9 ± 3.9 mmHg (14.2 ± 8.4%) for cortex and 2.6 ± 4.0 mmHg (7.7 ± 11.5%) for medulla. In the human subjects, BOLD-derived medullary Po2 increased from 16.0 ± 4.9 mmHg (SHb: 31 ± 11%) at baseline to 26.2 ± 3.1 mmHg (SHb: 53 ± 6%) at 5 min after furosemide injection, while cortical Po2 did not change significantly at ∼58 mmHg (SHb: 92 ± 1%). Our proposed method, validated with a porcine model, appears promising for estimating tissue Po2 from renal BOLD MRI data in human subjects.

Utility of blood oxygen level dependent magnetic resonance imaging in the evaluation of tissue oxygenation patterns of prostate cancer.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 198-198
Author(s):  
Bishoy A. Gayed ◽  
Rami Hallac ◽  
Ramy F. Youssef ◽  
Franto Francis ◽  
Qing Yuan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signal Intensity ◽  
Tissue Oxygenation ◽  
Blood Oxygen Level Dependent ◽  
Preoperative Imaging ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Bold Mri ◽  
Pathologic Features

198 Background: Tumor hypoxia is associated with worse pathologic features and oncological outcomes. Blood Oxygen Level Dependent (BOLD) MRI evaluates changes in endogenous contrast generated by paramagnetic deoxy-hemoglobin to non-invasively evaluate tissue oxygenation. Prior attempts using carbogen-based (95%O2 + 5%CO2) imaging were limited by patient tolerance. We present the first-in-man evaluation of a novel oxygen breathing challenge technique to monitor tissue oxygenation with BOLD MRI in patients with prostate cancer. Methods: Following IRB approval, 10 patients with clinically localized prostate cancer scheduled for radical prostatectomy underwent preoperative imaging with a 3-Tesla MRI scanner. Images were acquired using a 6-element SENSE body transmit coil and endorectal receive coil. T2* signal intensity is dependent on the concentration of deoxy-hemoglobin. Signal intensity measurements were obtained at different time points. Shorter T2* times imply the presence of hypoxia. Dynamic T2* maps were acquired while subjects breathed air for 2 mins followed by oxygen (15 l/min). Results: 10 patients (median age: 59 years (range 48-73), median PSA 6.9 ng/ml (range 2.5-25), with prostate cancer (Gleason sum 6- 7, 8-9 in 7 and 3 patients respectively) underwent BOLD MRI within 3 weeks of definitive management with a robotic assisted laparoscopic prostatectomy. All patients tolerated BOLD MRI with oxygen challenge without difficulty. Evaluation of BOLD MRI revealed wide variation in T2* values within the prostates from a median of 14.7 ± .71 ms to 44.5 ± 3.3ms. Surrounding muscle T2* values were similar for all patients, indicating that heterogeneous values were specific to each patient’s prostate. Shorter T2* values were seen in Gleason 6-7 than Gleason 8- 9 cancers, indicating more hypoxic areas in these tumors. HIF-1α staining was strongly positive in all tumors. Conclusions: BOLD MRI with oxygen challenge is well tolerated in patients and is a feasible noninvasive technique to study tissue oxygenation in tumors. Differential oxygenation patterns of prostates appear to correlate with pathological features. Further testing is needed to validate these findings.

scholarly journals Blood Oxygen Level–Dependent (BOLD) MRI in Renovascular Hypertension

2011 ◽  
Vol 13 (5) ◽  
pp. 370-377 ◽  
Author(s):  
Monika L. Gloviczki ◽  
Lilach O. Lerman ◽  
Stephen C. Textor
Keyword(s):  
Renovascular Hypertension ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Bold Mri

scholarly journals Comparison of the effects of independently-controlled end-tidal PCO2 and PO2 on blood oxygen level–dependent (BOLD) MRI

2007 ◽  
Vol 27 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Eitan Prisman ◽  
Marat Slessarev ◽  
Jay Han ◽  
Julien Poublanc ◽  
Alexandra Mardimae ◽  
...  
Keyword(s):  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Bold Mri ◽  
End Tidal

scholarly journals Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease

2021 ◽  
Vol 2 (2) ◽  
pp. 109-117
Author(s):  
Daniel R. Nemirovsky ◽  
Puneet Gupta ◽  
Sophia Hu ◽  
Raymond Wong ◽  
Avnesh S. Thakor
Keyword(s):  
Nephrotic Syndrome ◽  
Blood Oxygen Level Dependent ◽  
Glomerular Disease ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Glomerular Diseases ◽  
Bold Mri ◽  
Bold Imaging ◽  
Nephritic Syndrome

Renal hypoxia has recently been implicated as a key contributor and indicator of various glomerular diseases. As such, monitoring changes in renal oxygenation in these disorders may provide an early diagnostic advantage that could prevent potential adverse outcomes. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) is an emerging noninvasive technique for assessing renal oxygenation in glomerular disease. Although BOLD MRI has produced promising initial results for the use in certain renal pathologies, the use of BOLD imaging in glomerular diseases, including primary and secondary nephrotic and nephritic syndromes, is relatively unexplored. Early BOLD studies on primary nephrotic syndrome, nephrotic syndrome secondary to diabetes mellitus, and nephritic syndrome secondary to systemic lupus erythematosus have shown promising results to support its future clinical utility. In this review, we outline the advancements made in understanding the use of BOLD MRI for the assessment, diagnosis, and screening of these pathologies.

scholarly journals Gas challenge–blood oxygen level-dependent (GC-BOLD) MRI in the rat Novikoff hepatoma model

2012 ◽  
Vol 30 (1) ◽  
pp. 133-138 ◽  
Author(s):  
Yang Guo ◽  
Ning Jin ◽  
Rachel Klein ◽  
Jodi Nicolai ◽  
Guang-Yu Yang ◽  
...  
Keyword(s):  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Novikoff Hepatoma ◽  
Bold Mri ◽  
Hepatoma Model
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