Computed tomography and magnetic resonance imaging in cystic fibrosis lung disease

2010 ◽  
Vol 32 (6) ◽  
pp. 1370-1378 ◽  
Author(s):  
Monika Eichinger ◽  
Claus-Peter Heussel ◽  
Hans-Ulrich Kauczor ◽  
Harm Tiddens ◽  
Michael Puderbach
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
Resonance Imaging ◽  
Cystic Fibrosis Lung Disease

Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease

2019 ◽  
Vol 26 (3) ◽  
pp. 344-354 ◽  
Author(s):  
Giles Santyr ◽  
Nikhil Kanhere ◽  
Felipe Morgado ◽  
Jonathan H. Rayment ◽  
Felix Ratjen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
Resonance Imaging ◽  
Hyperpolarized Gas ◽  
Cystic Fibrosis Lung Disease

Non-contrast enhanced magnetic resonance imaging detects mosaic signal intensity in early cystic fibrosis lung disease

2018 ◽  
Vol 101 ◽  
pp. 178-183 ◽  
Author(s):  
Patricia Leutz-Schmidt ◽  
Mirjam Stahl ◽  
Olaf Sommerburg ◽  
Monika Eichinger ◽  
Michael U. Puderbach ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Signal Intensity ◽  
Cystic Fibrosis Lung ◽  
Resonance Imaging ◽  
Cystic Fibrosis Lung Disease ◽  
Contrast Enhanced

scholarly journals Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis

2019 ◽  
Vol 53 (5) ◽  
pp. 1802188 ◽  
Author(s):  
Jonathan H. Rayment ◽  
Marcus J. Couch ◽  
Nancy McDonald ◽  
Nikhil Kanhere ◽  
David Manson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Treatment Response ◽  
Forced Expiratory Volume ◽  
Response To Therapy ◽  
Breath Hold ◽  
Pulmonary Exacerbation ◽  
Resonance Imaging

Pulmonary magnetic resonance imaging using hyperpolarised 129Xe gas (XeMRI) can quantify ventilation inhomogeneity by measuring the percentage of unventilated lung volume (ventilation defect per cent (VDP)). While previous studies have demonstrated its sensitivity for detecting early cystic fibrosis (CF) lung disease, the utility of XeMRI to monitor response to therapy in CF is unknown. The aim of this study was to assess the ability of XeMRI to capture treatment response in paediatric CF patients undergoing inpatient antibiotic treatment for a pulmonary exacerbation.15 CF patients aged 8–18 years underwent XeMRI, spirometry, plethysmography and multiple-breath nitrogen washout at the beginning and end of inpatient treatment of a pulmonary exacerbation. VDP was calculated from XeMRI images obtained during a static breath hold using semi-automated k-means clustering and linear binning approaches.XeMRI was well tolerated. VDP, lung clearance index and the forced expiratory volume in 1 s all improved with treatment; however, response was not uniform in individual patients. Of all outcome measures, VDP showed the largest relative improvement (−42.1%, 95% CI −52.1–−31.9%, p<0.0001).These data support further investigation of XeMRI as a tool to capture treatment response in CF lung disease.

scholarly journals Quantitative multivolume proton-magnetic resonance imaging in patients with cystic fibrosis lung disease: comparison with clinical indicators

2019 ◽  
Vol 53 (5) ◽  
pp. 1702020 ◽  
Author(s):  
Francesca Pennati ◽  
Caterina Salito ◽  
Irene Borzani ◽  
Giulia Cervellin ◽  
Simone Gambazza ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Proton Magnetic Resonance ◽  
Magnetic Resonance Images ◽  
Imaging Biomarkers ◽  
Resonance Imaging ◽  
Clinical Indicators ◽  
Proton Magnetic Resonance Imaging

This cross-sectional study aims to verify the relationship between quantitative multivolume proton-magnetic resonance imaging (1H-MRI) and clinical indicators of ventilatory abnormalities in cystic fibrosis (CF) lung disease.Non-enhanced chest MRI, spirometry and multiple breath washout was performed by 28 patients (10–27 years) with CF lung disease. Images acquired at end-inspiration and end-expiration were registered by optical flow to estimate expiratory–inspiratory proton-density change (Δ1H-MRI) as a measure of regional ventilation. Magnetic resonance images were also evaluated using a CF-specific scoring system.Biomarkers of CF ventilation impairment were defined from the Δ1H-MRI as follows: Δ1H-MRI median, Δ1H-MRI quartile coefficient of variation (QCV) and percentage of low-ventilation volume (%LVV). Imaging biomarkers correlated to all the clinical measures of ventilation abnormality, with the strongest correlation between Δ1H-MRI median and forced expiratory volume in 1 s (r2=0.44, p<0.001), Δ1H-MRI QCV and lung clearance index (LCI) (r2=0.51, p<0.001) and %LVV and LCI (r2=0.66, p<0.001). Correlations were also found between imaging biomarkers of ventilation and morphological scoring.The study showed a significant correlation between quantitative multivolume MRI and clinical indicators of CF lung disease. MRI, as a non-ionising imaging technique, may be particularly attractive in CF care for longitudinal evaluation, providing a new imaging biomarker to detect early ventilatory abnormalities.

Monitoring Cystic Fibrosis Lung Disease by Computed Tomography. Radiation Risk in Perspective

2014 ◽  
Vol 189 (11) ◽  
pp. 1328-1336 ◽  
Author(s):  
Wieying Kuo ◽  
Pierluigi Ciet ◽  
Harm A. W. M. Tiddens ◽  
Wei Zhang ◽  
R. Paul Guillerman ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cystic Fibrosis ◽  
Lung Disease ◽  
Radiation Risk ◽  
Cystic Fibrosis Lung ◽  
Cystic Fibrosis Lung Disease
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