scholarly journals In vivo MR imaging tracking of transplanted mesenchymal stem cells in a rabbit model of acute peripheral nerve traction injury

2010 ◽  
Vol 32 (5) ◽  
pp. 1076-1085 ◽  
Author(s):  
Jun Shen ◽  
Xiao-Hui Duan ◽  
Li-Na Cheng ◽  
Xiao-Mei Zhong ◽  
Ruo-Mi Guo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mr Imaging ◽  
Peripheral Nerve ◽  
Rabbit Model ◽  
Traction Injury

scholarly journals In Vivo MR Imaging of Intraarterially Delivered Magnetically Labeled Mesenchymal Stem Cells in a Canine Stroke Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e54963 ◽  
Author(s):  
Shan-shan Lu ◽  
Sheng Liu ◽  
Qing-quan Zu ◽  
Xiao-quan Xu ◽  
Jing Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mr Imaging ◽  
Stroke Model

scholarly journals Mesenchymal Stem Cells Exhibit Both a Proinflammatory and Anti-Inflammatory Effect on Saccular Aneurysm Formation in a Rabbit Model

2019 ◽  
Vol 2019 ◽  
pp. 1-15
Author(s):  
Michael B. Avery ◽  
Brooke L. Belanger ◽  
Amy Bromley ◽  
Arindom Sen ◽  
Alim P. Mitha
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rabbit Model ◽  
Potential Interaction ◽  
Allogenic Bone ◽  
Aneurysm Formation ◽  
Vehicle Injection ◽  
Anti Inflammatory

Several studies have demonstrated a potential interaction between mesenchymal stem cells (MSCs) and saccular aneurysms. In this study, we sought to determine whether allogenic bone marrow-derived MSCs had the ability to prevent aneurysm formation in a known rabbit elastase aneurysm model. MSCs were injected intravenously in experimental rabbits at the time of surgical creation and two weeks postcreation and compared with control rabbits receiving vehicle injection. Angiography was used to compare aneurysm measurements four weeks postcreation, and aneurysms were harvested for histological properties. Serum was collected longitudinally to evaluate cytokine alterations. Serum from control animals was also utilized to perform in vitro tests with MSCs to compare the effect of the serologic environment in animals with and without aneurysms on MSC proliferation and cytokine production. While aneurysm morphometric comparisons revealed no differences, significant cytokine alterations were observed in vitro and in vivo, suggesting both anti-inflammatory and proinflammatory processes were occurring in the presence of MSCs. Histological analyses suggested that tunica intima hyperplasia was inhibited in the presence of MSCs.

scholarly journals In vivo MR imaging of magnetically labeled mesenchymal stem cells transplanted into rat liver through hepatic arterial injection

2008 ◽  
Vol 3 (2) ◽  
pp. 72-77 ◽  
Author(s):  
Jinhua Cai ◽  
Xuemei Zhang ◽  
Xin Wang ◽  
Chuan Li ◽  
Guanxin Liu
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mr Imaging ◽  
Rat Liver

In vivo MR Imaging of Tissue-engineered Human Mesenchymal Stem Cells Transplanted to Mouse: a Preliminary Study

2006 ◽  
Vol 35 (1) ◽  
pp. 101-108 ◽  
Author(s):  
In Kap Ko ◽  
Ho-Taek Song ◽  
Eun-Jin Cho ◽  
Eun Sook Lee ◽  
Yong-Min Huh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mr Imaging ◽  
Human Mesenchymal Stem Cells ◽  
Preliminary Study

scholarly journals Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model

Biology ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 230
Author(s):  
Girish Pattappa ◽  
Jonas Krueckel ◽  
Ruth Schewior ◽  
Dustin Franke ◽  
Alexander Mench ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Repair ◽  
Rabbit Model ◽  
Cartilage Regeneration ◽  
Cartilage Defects ◽  
Large Animal ◽  
Large Animal Models ◽  
Early Oa

Focal early osteoarthritis (OA) or degenerative lesions account for 60% of treated cartilage defects each year. The current cell-based regenerative treatments have an increased failure rate for treating degenerative lesions compared to traumatic defects. Mesenchymal stem cells (MSCs) are an alternative cell source for treating early OA defects, due to their greater chondrogenic potential, compared to early OA chondrocytes. Low oxygen tension or physioxia has been shown to enhance MSC chondrogenic matrix content and could improve functional outcomes of regenerative therapies. The present investigation sought to develop a focal early OA animal model to evaluate cartilage regeneration and hypothesized that physioxic MSCs improve in vivo cartilage repair in both, post-trauma and focal early OA defects. Using a rabbit model, a focal defect was created, that developed signs of focal early OA after six weeks. MSCs cultured under physioxia had significantly enhanced in vitro MSC chondrogenic GAG content under hyperoxia with or without the presence of interleukin-1β (IL-1β). In both post-traumatic and focal early OA defect models, physioxic MSC treatment demonstrated a significant improvement in cartilage repair score, compared to hyperoxic MSCs and respective control defects. Future investigations will seek to understand whether these results are replicated in large animal models and the underlying mechanisms involved in in vivo cartilage regeneration.

In Vivo MR Imaging of Intravascularly Injected Magnetically Labeled Mesenchymal Stem Cells in Rat Kidney and Liver

Radiology ◽  
2004 ◽  
Vol 233 (3) ◽  
pp. 781-789 ◽  
Author(s):  
Clemens Bos ◽  
Yahsou Delmas ◽  
Alexis Desmoulière ◽  
Anne Solanilla ◽  
Olivier Hauger ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mr Imaging ◽  
Rat Kidney

scholarly journals In Vivo MR Imaging of Magnetically Labeled Mesenchymal Stem Cells in a Rat Model of Renal Ischemia

2009 ◽  
Vol 10 (3) ◽  
pp. 277 ◽  
Author(s):  
Sung Il Jung ◽  
Seung Hyup Kim ◽  
Hyo-Cheol Kim ◽  
Kyu Ri Son ◽  
Se Young Chung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mr Imaging ◽  
Rat Model ◽  
Renal Ischemia

scholarly journals In vivo Evaluation of Nanostructured Fibrin-Agarose Hydrogels With Mesenchymal Stem Cells for Peripheral Nerve Repair

2018 ◽  
Vol 12 ◽  
Author(s):  
Jesús Chato-Astrain ◽  
Fernando Campos ◽  
Olga Roda ◽  
Esther Miralles ◽  
Daniel Durand-Herrera ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Nerve Repair ◽  
In Vivo Evaluation ◽  
Peripheral Nerve Repair
Sign in / Sign up

Export Citation Format

Share Document