scholarly journals Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: The LADIS (leukoaraiosis and disability in the elderly) study

2009 ◽  
Vol 29 (2) ◽  
pp. 268-274 ◽  
Author(s):  
Stefan Ropele ◽  
Alexandra Seewann ◽  
Alida A. Gouw ◽  
Wiesje M. van der Flier ◽  
Reinhold Schmidt ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Tissue ◽  
White Matter Hyperintensities ◽  
Magnetization Transfer ◽  
The Elderly ◽  
Magnetization Transfer Imaging ◽  
Diffusion Weighted ◽  
Tissue Changes

Arterial stiffness and white matter integrity in the elderly: A diffusion tensor and magnetization transfer imaging study

NeuroImage ◽  
2019 ◽  
Vol 186 ◽  
pp. 577-585 ◽  
Author(s):  
Atef Badji ◽  
Adrián Noriega de la Colina ◽  
Agah Karakuzu ◽  
Tanguy Duval ◽  
Laurence Desjardins-Crépeau ◽  
...  
Keyword(s):  
White Matter ◽  
Arterial Stiffness ◽  
Diffusion Tensor ◽  
Magnetization Transfer ◽  
Imaging Study ◽  
The Elderly ◽  
White Matter Integrity ◽  
Magnetization Transfer Imaging

scholarly journals Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women

2010 ◽  
Vol 31 (7) ◽  
pp. 1197-1204 ◽  
Author(s):  
Caterina Rosano ◽  
Sigurdur Sigurdsson ◽  
Kristin Siggeirsdottir ◽  
Caroline L. Phillips ◽  
Melissa Garcia ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Atrophy ◽  
White Matter Hyperintensities ◽  
Magnetization Transfer ◽  
Older Men ◽  
Magnetization Transfer Imaging ◽  
Men And Women ◽  
Older Men And Women

scholarly journals Lobar Distribution of Changes in Gray Matter and White Matter in Memory Clinic Patients: Detected Using Magnetization Transfer Imaging

2007 ◽  
Vol 28 (10) ◽  
pp. 1938-1942 ◽  
Author(s):  
A.C.G.M. van Es ◽  
W.M. van der Flier ◽  
F. Admiraal Behloul ◽  
H. Olofsen ◽  
E.L.E.M. Bollen ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Imaging ◽  
Memory Clinic

scholarly journals White Matter Hyperintensities Predict Cognitive Decline: A Community-Based Study

2019 ◽  
Vol 46 (04) ◽  
pp. 383-388 ◽  
Author(s):  
Xuemei Qi ◽  
Huidong Tang ◽  
Qi Luo ◽  
Bei Ding ◽  
Jie Chen ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
White Matter Hyperintensities ◽  
Smoking Status ◽  
Brain Magnetic Resonance Imaging ◽  
The Elderly ◽  
Brain Regions ◽  
Cholinergic Pathways ◽  
Mri Scans ◽  
Magnetic Resonance Imaging Mri

ABSTRACT:Introduction: White matter hyperintensities (WMHs) were commonly seen in brain magnetic resonance imaging (MRI) of the elderly. Many studies found that WMHs were associated with cognitive decline and dementia. However, the association between WMHs in different brain regions and cognitive decline remains debated. Methods: We explored the association of the severity of WMHs and cognitive decline in 115 non-demented elderly (≥50 years old) sampled from the Wuliqiao Community located in urban area of Shanghai. MRI scans were done during 2009–2011 at the beginning of the study. Severity of WMHs in different brain regions was scored by Improved Scheltens Scale and Cholinergic Pathways Hyperintensities Scale (CHIPS). Cognitive function was evaluated by Mini-Mental State Examination (MMSE) every 2 to 4 years during 2009–2018. Results: After adjusting for confounding factors including age, gender, education level, smoking status, alcohol consumption, depression, hypertension, diabetes, hyperlipidemia, brain infarcts, brain atrophy, apoE4 status, and baseline MMSE score, periventricular and subcortical WMH lesions as well as WMHs in cholinergic pathways were significantly associated with annual MMSE decline ( p < 0.05), in which the severity of periventricular WMHs predicted a faster MMSE decline (–0.187 points/year, 95% confidence interval: –0.349, –0.026, p = 0.024). Conclusions: The severity of WMHs at baseline was associated with cognitive decline in the non-demented elderly over time. Interventions on WMH lesions may offer some benefits for cognitive deterioration.

White matter hyperintensities analysis by diffusion tensor images obtained from postmortem in cranium whole brain tissue

2016 ◽  
Vol 6 ◽  
pp. 21-27
Author(s):  
Rafael E. Silva ◽  
Glaucia A.B. Santos ◽  
Ana T.D.L. Alho ◽  
Ricardo C. Neves ◽  
Luzia, L. Carreira ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Tissue ◽  
White Matter Hyperintensities ◽  
Diffusion Tensor ◽  
Whole Brain ◽  
Diffusion Tensor Images

IC-P-014: The functional impact of cerebral white matter hyperintensities in the elderly

2009 ◽  
Vol 5 (4S_Part_1) ◽  
pp. P10-P11
Author(s):  
Melissa E. Murray ◽  
Matthew L. Senjem ◽  
John H. Hollman ◽  
Stephen Weigand ◽  
Dennis W. Dickson ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
The Elderly ◽  
Cerebral White Matter ◽  
Functional Impact

scholarly journals Differential Progression of Magnetization Transfer Imaging Changes Depending on Severity of Cerebral Hypoxic-Ischemic Injury

2008 ◽  
Vol 28 (9) ◽  
pp. 1613-1623 ◽  
Author(s):  
Ursula I Tuor ◽  
Shuzhen Meng ◽  
Min Qiao ◽  
Nicole B Webster ◽  
Shauna M Crowley ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetization Transfer ◽  
Ischemic Injury ◽  
Subcortical White Matter ◽  
Cerebral Injury ◽  
Magnetization Transfer Ratio ◽  
Magnetization Transfer Imaging ◽  
Cerebral Hypoxia ◽  
Hypoxia Ischemia ◽  
Hypoxic Ischemic Injury

We hypothesized that magnetic resonance magnetization transfer (MT) imaging would be sensitive for detecting cerebral ischemic injury in white matter of neonatal brain. We compared the progression of changes in T2 and the MT ratio (MTR) after cerebral hypoxic-ischemic insults of differing severity in neonatal rats. Magnetization transfer imaging parameters were first optimized, and then MTR and T2 maps were acquired at various times after a mild (rather selective white matter) or substantial insult produced by unilateral cerebral hypoxia—ischemia. Depending on insult severity, time after insult, and region (e.g., subcortical white matter or cortex), cerebral hypoxia—ischemia produced reductions in MTR and an increase in T2. The exception was acutely at 1 to 5 h at which time points MTR was reduced ipsilaterally in white matter, whereas T2 was not affected significantly. Progression of imaging changes differed in rats grouped according to whether gross damage was present after chronic recovery. Behavioral changes were generally associated with chronic reductions in MTR and gross brain damage. Magnetization transfer imaging was capable of early detection of hypoxic-ischemic injury and particularly sensitive for identifying the progression of cerebral injury in white matter. Magnetization transfer ratio has potential for assisting with early diagnosis and treatment assessment for infants affected by perinatal hypoxia—ischemia.

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