scholarly journals Manganese-enhanced MRI of the rat visual pathway: Acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn2+

2008 ◽  
Vol 28 (4) ◽  
pp. 855-865 ◽  
Author(s):  
Marte Thuen ◽  
Martin Berry ◽  
Tina Bugge Pedersen ◽  
Pål Erik Goa ◽  
Mike Summerfield ◽  
...  
Keyword(s):  
Contrast Enhancement ◽  
Axonal Transport ◽  
Visual Pathway ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri ◽  
Neural Toxicity

scholarly journals Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI

NeuroImage ◽  
2012 ◽  
Vol 60 (3) ◽  
pp. 1856-1866 ◽  
Author(s):  
Joseph J. Gallagher ◽  
Xiaowei Zhang ◽  
Gregory J. Ziomek ◽  
Russell E. Jacobs ◽  
Elaine L. Bearer
Keyword(s):  
Axonal Transport ◽  
Visual Pathway ◽  
Knock Out ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

Radiation-induced impairment of optic nerve axonal transport in tree shrews and rats monitored by longitudinal manganese-enhanced MRI

2020 ◽  
Vol 77 ◽  
pp. 145-154
Author(s):  
Jun Yang ◽  
Qinqing Li ◽  
Dan Han ◽  
Chengde Liao ◽  
Pengfei Wang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Axonal Transport ◽  
Tree Shrews ◽  
Enhanced Mri ◽  
Radiation Induced ◽  
Manganese Enhanced Mri

scholarly journals Axonal tracing of the normal and regenerating visual pathway of mouse, rat, frog, and fish using manganese-enhanced MRI (MEMRI)

2011 ◽  
Vol 34 (3) ◽  
pp. 670-675 ◽  
Author(s):  
Axel Sandvig ◽  
Ioanna Sandvig ◽  
Martin Berry ◽  
Øystein Olsen ◽  
Tina Bugge Pedersen ◽  
...  
Keyword(s):  
Visual Pathway ◽  
Enhanced Mri ◽  
Axonal Tracing ◽  
Manganese Enhanced Mri

scholarly journals Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats

2005 ◽  
Vol 22 (4) ◽  
pp. 492-500 ◽  
Author(s):  
Marte Thuen ◽  
Trond E. Singstad ◽  
Tina Bugge Pedersen ◽  
Olav Haraldseth ◽  
Martin Berry ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
Visual Pathway ◽  
Optic Nerve Injury ◽  
Adult Rats ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eugene Kim ◽  
Davide Di Censo ◽  
Mattia Baraldo ◽  
Camilla Simmons ◽  
Ilaria Rosa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Plaques ◽  
Transgenic Animals ◽  
Surrounding Tissue ◽  
Rodent Models ◽  
Enhanced Mri ◽  
5Xfad Mice ◽  
Manganese Enhanced Mri

AbstractAmyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in transgenic rodent models of AD across two species: 5xFAD mice and TgF344-AD rats. Animals were given subcutaneous injections of MnCl2 and imaged in vivo using a 9.4 T Bruker scanner. MnCl2 improved signal-to-noise ratio but was not necessary to detect plaques in high-resolution images. Plaques were visible in all transgenic animals and no wild-types, and quantitative susceptibility mapping showed that they were more paramagnetic than the surrounding tissue. This, combined with beta-amyloid and iron staining, indicate that plaque MR visibility in both animal models was driven by plaque size and iron load. Longitudinal relaxation rate mapping revealed increased manganese uptake in brain regions of high plaque burden in transgenic animals compared to their wild-type littermates. This was limited to the rhinencephalon in the TgF344-AD rats, while it was most significantly increased in the cortex of the 5xFAD mice. Alizarin Red staining suggests that manganese bound to plaques in 5xFAD mice but not in TgF344-AD rats. Multi-parametric MEMRI is a simple, viable method for detecting amyloid plaques in rodent models of AD. Manganese-induced signal enhancement can enable higher-resolution imaging, which is key to visualizing these small amyloid deposits. We also present the first in vivo evidence of manganese as a potential targeted contrast agent for imaging plaques in the 5xFAD model of AD.

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