scholarly journals Monitoring infection and inflammation in murine models of cystic fibrosis with magnetic resonance imaging

2008 ◽  
Vol 28 (2) ◽  
pp. 527-532 ◽  
Author(s):  
Vipul R. Sheth ◽  
R. Christiaan van Heeckeren ◽  
Alma G. Wilson ◽  
Anna M. van Heeckeren ◽  
Mark D. Pagel
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Murine Models ◽  
Resonance Imaging ◽  
Infection And Inflammation

Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease

2019 ◽  
Vol 26 (3) ◽  
pp. 344-354 ◽  
Author(s):  
Giles Santyr ◽  
Nikhil Kanhere ◽  
Felipe Morgado ◽  
Jonathan H. Rayment ◽  
Felix Ratjen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
Resonance Imaging ◽  
Hyperpolarized Gas ◽  
Cystic Fibrosis Lung Disease

Magnetic Resonance Imaging of the Lung: Cystic Fibrosis

2017 ◽  
pp. 277-291 ◽  
Author(s):  
Scott K. Nagle ◽  
Michael Puderbach ◽  
Monika Eichinger ◽  
Talissa A. Altes
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Resonance Imaging

scholarly journals Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis

2019 ◽  
Vol 53 (5) ◽  
pp. 1802188 ◽  
Author(s):  
Jonathan H. Rayment ◽  
Marcus J. Couch ◽  
Nancy McDonald ◽  
Nikhil Kanhere ◽  
David Manson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Treatment Response ◽  
Forced Expiratory Volume ◽  
Response To Therapy ◽  
Breath Hold ◽  
Pulmonary Exacerbation ◽  
Resonance Imaging

Pulmonary magnetic resonance imaging using hyperpolarised 129Xe gas (XeMRI) can quantify ventilation inhomogeneity by measuring the percentage of unventilated lung volume (ventilation defect per cent (VDP)). While previous studies have demonstrated its sensitivity for detecting early cystic fibrosis (CF) lung disease, the utility of XeMRI to monitor response to therapy in CF is unknown. The aim of this study was to assess the ability of XeMRI to capture treatment response in paediatric CF patients undergoing inpatient antibiotic treatment for a pulmonary exacerbation.15 CF patients aged 8–18 years underwent XeMRI, spirometry, plethysmography and multiple-breath nitrogen washout at the beginning and end of inpatient treatment of a pulmonary exacerbation. VDP was calculated from XeMRI images obtained during a static breath hold using semi-automated k-means clustering and linear binning approaches.XeMRI was well tolerated. VDP, lung clearance index and the forced expiratory volume in 1 s all improved with treatment; however, response was not uniform in individual patients. Of all outcome measures, VDP showed the largest relative improvement (−42.1%, 95% CI −52.1–−31.9%, p<0.0001).These data support further investigation of XeMRI as a tool to capture treatment response in CF lung disease.

scholarly journals Quantitative multivolume proton-magnetic resonance imaging in patients with cystic fibrosis lung disease: comparison with clinical indicators

2019 ◽  
Vol 53 (5) ◽  
pp. 1702020 ◽  
Author(s):  
Francesca Pennati ◽  
Caterina Salito ◽  
Irene Borzani ◽  
Giulia Cervellin ◽  
Simone Gambazza ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Proton Magnetic Resonance ◽  
Magnetic Resonance Images ◽  
Imaging Biomarkers ◽  
Resonance Imaging ◽  
Clinical Indicators ◽  
Proton Magnetic Resonance Imaging

This cross-sectional study aims to verify the relationship between quantitative multivolume proton-magnetic resonance imaging (1H-MRI) and clinical indicators of ventilatory abnormalities in cystic fibrosis (CF) lung disease.Non-enhanced chest MRI, spirometry and multiple breath washout was performed by 28 patients (10–27 years) with CF lung disease. Images acquired at end-inspiration and end-expiration were registered by optical flow to estimate expiratory–inspiratory proton-density change (Δ1H-MRI) as a measure of regional ventilation. Magnetic resonance images were also evaluated using a CF-specific scoring system.Biomarkers of CF ventilation impairment were defined from the Δ1H-MRI as follows: Δ1H-MRI median, Δ1H-MRI quartile coefficient of variation (QCV) and percentage of low-ventilation volume (%LVV). Imaging biomarkers correlated to all the clinical measures of ventilation abnormality, with the strongest correlation between Δ1H-MRI median and forced expiratory volume in 1 s (r2=0.44, p<0.001), Δ1H-MRI QCV and lung clearance index (LCI) (r2=0.51, p<0.001) and %LVV and LCI (r2=0.66, p<0.001). Correlations were also found between imaging biomarkers of ventilation and morphological scoring.The study showed a significant correlation between quantitative multivolume MRI and clinical indicators of CF lung disease. MRI, as a non-ionising imaging technique, may be particularly attractive in CF care for longitudinal evaluation, providing a new imaging biomarker to detect early ventilatory abnormalities.

Magnetic resonance imaging is an accurate and reliable method to evaluate non-cystic fibrosis paediatric lung disease

Respirology ◽  
2011 ◽  
Vol 17 (1) ◽  
pp. 87-91 ◽  
Author(s):  
SILVIA MONTELLA ◽  
MARCO MAGLIONE ◽  
DARIO BRUZZESE ◽  
CARMINE MOLLICA ◽  
CLAUDIO PIGNATA ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Reliable Method ◽  
Resonance Imaging ◽  
Paediatric Lung Disease
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