scholarly journals Proton MR spectroscopic imaging of the medulla and cervical spinal cord

2007 ◽  
Vol 26 (4) ◽  
pp. 1101-1105 ◽  
Author(s):  
Richard A.E. Edden ◽  
David Bonekamp ◽  
Mari A. Smith ◽  
Prachi Dubey ◽  
Peter B. Barker
Author(s):  
L. Vacca-Galloway ◽  
Y.Q. Zhang ◽  
P. Bose ◽  
S.H. Zhang

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.


2001 ◽  
Vol 120 (5) ◽  
pp. A116-A116
Author(s):  
H SCHLEMMER ◽  
T SAWATZKI ◽  
I DORNACHER ◽  
S SAMMET ◽  
M HELLENSCHMIDT ◽  
...  

1994 ◽  
Vol 31 (2) ◽  
pp. 185
Author(s):  
Yong Whee Bahk ◽  
Kyung Sub Shinn ◽  
Tae Suk Suh ◽  
Bo Young Choe ◽  
Kyo Ho Choi

1992 ◽  
Vol 158 (6) ◽  
pp. 1413-1413
Author(s):  
T E Barros ◽  
R P Oliveira ◽  
L A Rosemberg ◽  
A C Magalhães

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