scholarly journals Qualitative and quantitative analysis of regional left ventricular wall dynamics using real-time magnetic resonance imaging: Comparison with conventional breath-hold gradient echo acquisition in volunteers and patients

2001 ◽  
Vol 14 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Sven Plein ◽  
William H.T. Smith ◽  
John P. Ridgway ◽  
Andrea Kassner ◽  
David J. Beacock ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Quantitative Analysis ◽  
Magnetic Resonance ◽  
Left Ventricular ◽  
Breath Hold ◽  
Ventricular Wall ◽  
Qualitative And Quantitative Analysis ◽  
Resonance Imaging ◽  
Gradient Echo ◽  
Qualitative And Quantitative

Relation of B-type natriuretic peptide to left ventricular wall stress as assessed by cardiac magnetic resonance imaging in patients with dilated cardiomyopathy

2007 ◽  
Vol 85 (8) ◽  
pp. 790-799 ◽  
Author(s):  
P. Alter ◽  
H. Rupp ◽  
M.B. Rominger ◽  
A. Vollrath ◽  
F. Czerny ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Wall Stress ◽  
Left Ventricular ◽  
Ventricular Wall ◽  
Resonance Imaging ◽  
Sphere Model ◽  
Lv Mass ◽  
Systolic Wall Stress

Ventricular loading conditions are crucial determinants of cardiac function and prognosis in heart failure. B-type natriuretic peptide (BNP) is mainly stored in the ventricular myocardium and is released in response to an increased ventricular filling pressure. We examined, therefore, the hypothesis that BNP serum concentrations are related to ventricular wall stress. Cardiac magnetic resonance imaging (MRI) was used to assess left ventricular (LV) mass and cardiac function of 29 patients with dilated cardiomyopathy and 5 controls. Left ventricular wall stress was calculated by using a thick-walled sphere model, and BNP was assessed by immunoassay. LV mass (r = 0.73, p < 0.001) and both LV end-diastolic (r = 0.54, p = 0.001) and end-systolic wall stress (r = 0.66, p < 0.001) were positively correlated with end-diastolic volume. LV end-systolic wall stress was negatively related to LV ejection fraction (EF), whereas end-diastolic wall stress was not related to LVEF. BNP concentration correlated positively with LV end-diastolic wall stress (r = 0.50, p = 0.002). Analysis of variance revealed LV end-diastolic wall stress as the only independent hemodynamic parameter influencing BNP (p < 0.001). The present approach using a thick-walled sphere model permits determination of mechanical wall stress in a clinical routine setting using standard cardiac MRI protocols. A correlation of BNP concentration with calculated LV stress was observed in vivo. Measurement of BNP seems to be sufficient to assess cardiac loading conditions. Other relations of BNP with various hemodynamic parameters (e.g., EF) appear to be secondary. Since an increased wall stress is associated with cardiac dilatation, early diagnosis and treatment could potentially prevent worsening of the outcome.

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