Can dynamic susceptibility contrast magnetic resonance imaging perfusion data be analyzed using a model based on directional flow?

2003 ◽  
Vol 17 (2) ◽  
pp. 241-255 ◽  
Author(s):  
N.A. Thacker ◽  
M.L.J. Scott ◽  
A. Jackson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Dynamic Susceptibility ◽  
Resonance Imaging ◽  
Dynamic Susceptibility Contrast ◽  
Directional Flow ◽  
Contrast Magnetic Resonance Imaging ◽  
Magnetic Resonance Imaging Perfusion ◽  
Contrast Magnetic Resonance ◽  
Susceptibility Contrast

scholarly journals Anisotropic cerebral vascular architecture causes orientation dependency in cerebral blood flow and volume measured with dynamic susceptibility contrast magnetic resonance imaging

2016 ◽  
Vol 37 (3) ◽  
pp. 1108-1119 ◽  
Author(s):  
Enedino Hernández-Torres ◽  
Nora Kassner ◽  
Nils Daniel Forkert ◽  
Luxi Wei ◽  
Vanessa Wiggermann ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Dynamic Susceptibility ◽  
Resonance Imaging ◽  
Dynamic Susceptibility Contrast ◽  
Contrast Magnetic Resonance Imaging ◽  
Contrast Magnetic Resonance ◽  
Tissue Orientation ◽  
Susceptibility Contrast

Measurements of cerebral perfusion using dynamic susceptibility contrast magnetic resonance imaging rely on the assumption of isotropic vascular architecture. However, a considerable fraction of vessels runs in parallel with white matter tracts. Here, we investigate the effects of tissue orientation on dynamic susceptibility contrast magnetic resonance imaging. Tissue orientation was measured using diffusion tensor imaging and dynamic susceptibility contrast was performed with gradient echo planar imaging. Perfusion parameters and the raw dynamic susceptibility contrast signals were correlated with tissue orientation. Additionally, numerical simulations were performed for a range of vascular volumes of both the isotropic vascular bed and anisotropic vessel components, as well as for a range of contrast agent concentrations. The effect of the contrast agent was much larger in white matter tissue perpendicular to the main magnetic field compared to white matter parallel to the main magnetic field. In addition, cerebral blood flow and cerebral blood volume were affected in the same way with angle-dependent variations of up to 130%. Mean transit time and time to maximum of the residual curve exhibited weak orientation dependency of 10%. Numerical simulations agreed with the measured data, showing that one-third of the white matter vascular volume is comprised of vessels running in parallel with the fibre tracts.

Practical Clinical Use of Dynamic Susceptibility Contrast Magnetic Resonance Imaging for the Surgical Treatment of Moyamoya Disease

Neurosurgery ◽  
2013 ◽  
Vol 74 (3) ◽  
pp. 302-309 ◽  
Author(s):  
Yosuke Ishii ◽  
Tadashi Nariai ◽  
Yoji Tanaka ◽  
Maki Mukawa ◽  
Motoki Inaji ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Bypass Surgery ◽  
Dynamic Susceptibility ◽  
Resonance Imaging ◽  
Dynamic Susceptibility Contrast ◽  
Contrast Magnetic Resonance Imaging ◽  
Contrast Magnetic Resonance ◽  
Susceptibility Contrast ◽  
Ischemic Events

Abstract BACKGROUND: Precise evaluation of hemodynamic stress is important for the treatment of moyamoya disease (MMD). OBJECTIVE: To explore whether dynamic susceptibility contrast magnetic resonance imaging could predict the effects and risk of indirect bypass surgery on MMD. METHODS: Clinical data of patients with MMD who were evaluated preoperatively and postoperatively with dynamic susceptibility contrast magnetic resonance imaging and digital subtraction angiography were evaluated retrospectively. Indirect bypass surgery was performed on 115 hemispheres of 69 patients (mean age, 15 years; range, 3-54 years). We examined the correlations of ischemic events and revascularization with the mean transit time (MTT) delay to cerebellum. RESULTS: The hemispheres that caused the ischemic events (responsible hemisphere) had a significantly longer preoperative MTT delay than the nonresponsible hemispheres (2.66 ± 1.34 vs 1.57 ± 1.09 seconds). The postoperative MTT delay fell significantly in the patients whose symptoms disappeared (preoperative, 2.61 ± 1.35 seconds; postoperative, 1.35 ± 0.96 seconds). Perioperative infarction occurred in 4 hemispheres (3.5%), and the MTT delay was significantly longer in those hemispheres than in the others (3.97 ± 1.20 vs 2.38 ± 1.34 seconds). The MTT delay was significantly longer in patients with higher angiographic stages. Indirect bypass surgery ameliorated the MTT delay to the same degree in adults and children. Digital subtraction angiography revealed that the induced revascularization was far superior in areas with longer MTT delays. CONCLUSION: Dynamic susceptibility contrast magnetic resonance imaging proved to be a useful clinical imaging method for patients with MMD. It may be helpful for selecting candidates for MMD intervention and for predicting the effects and risks of surgery.

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