scholarly journals Dynamic coronary MR angiography and first-pass perfusion with intracoronary administration of contrast agent

2002 ◽  
Vol 16 (3) ◽  
pp. 311-319 ◽  
Author(s):  
Nikolaos V. Tsekos ◽  
Pamela K. Woodard ◽  
Glenn J. Foster ◽  
Pavlos Moustakidis ◽  
Terry L. Sharp ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mr Angiography ◽  
Pass Perfusion ◽  
Intracoronary Administration ◽  
First Pass ◽  
Coronary Mr Angiography ◽  
First Pass Perfusion

scholarly journals Contrast-Enhanced Magnetic Resonance Angiography Using a Novel Elastin-Specific Molecular Probe in an Experimental Animal Model

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Carolin Reimann ◽  
Julia Brangsch ◽  
Jan Ole Kaufmann ◽  
Lisa C. Adams ◽  
David C. Onthank ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Image Quality ◽  
Magnetic Resonance Angiography ◽  
Contrast Agent ◽  
Mr Angiography ◽  
Molecular Probe ◽  
Time Resolved ◽  
Clinical Dose ◽  
Contrast Enhanced ◽  
First Pass

Objectives. The aim of this study was to test the potential of a new elastin-specific molecular agent for the performance of contrast-enhanced first-pass and 3D magnetic resonance angiography (MRA), compared to a clinically used extravascular contrast agent (gadobutrol) and based on clinical MR sequences. Materials and Methods. Eight C57BL/6J mice (BL6, male, aged 10 weeks) underwent a contrast-enhanced first-pass and 3D MR angiography (MRA) of the aorta and its main branches. All examinations were on a clinical 3 Tesla MR system (Siemens Healthcare, Erlangen, Germany). The clinical dose of 0.1 mmol/kg was administered in both probes. First, a time-resolved MRA (TWIST) was acquired during the first-pass to assess the arrival and washout of the contrast agent bolus. Subsequently, a high-resolution 3D MRA sequence (3D T1 FLASH) was acquired. Signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) were calculated for all sequences. Results. The elastin-specific MR probe and the extravascular imaging agent (gadobutrol) enable high-quality MR angiograms in all animals. During the first-pass, the probes demonstrated a comparable peak enhancement (300.6 ± 32.9 vs. 288.5 ± 33.1, p>0.05). Following the bolus phase, both agents showed a comparable intravascular enhancement (SNR: 106.7 ± 11 vs. 102.3 ± 5.3; CNR 64.5 ± 7.4 vs. 61.1 ± 7.2, p>0.05). Both agents resulted in a high image quality with no statistical difference (p>0.05). Conclusion. The novel elastin-specific molecular probe enables the performance of first-pass and late 3D MR angiography with an intravascular contrast enhancement and image quality comparable to a clinically used extravascular contrast agent.

scholarly journals Qualitative assessments of myocardial ischemia by cardiac MRI and coronary stenosis by invasive coronary angiography in relation to quantitative perfusion by positron emission tomography in patients with known or suspected stable coronary artery disease

2018 ◽  
Vol 27 (6) ◽  
pp. 2351-2359 ◽  
Author(s):  
Shahnaz Akil ◽  
Fredrik Hedeer ◽  
Marcus Carlsson ◽  
Håkan Arheden ◽  
Jenny Oddstig ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Stable Coronary Artery Disease ◽  
Cardiac Pet ◽  
Flow Reserve ◽  
Pass Perfusion ◽  
First Pass ◽  
Artery Disease ◽  
Stable Cad ◽  
First Pass Perfusion ◽  
Perfusion Cmr

Abstract Background To relate findings of qualitative evaluation of first-pass perfusion-CMR and anatomical evaluation on coronary angiography (CA) to the reference standard of quantitative perfusion, cardiac PET, in patients with suspected or known stable coronary artery disease (CAD). Methods and Results Forty-one patients referred for CA due to suspected stable CAD, prospectively performed adenosine stress/rest first-pass perfusion-CMR as well as 13N-NH3 PET on the same day, 4 ± 3 weeks before CA. Angiographers were blinded to PET and CMR results. Regional myocardial flow reserve (MFR) < 2.0 on PET was considered pathological. Vessel territories with stress-induced ischemia by CMR or vessels with stenosis needing revascularization had a significantly lower MFR compared to those with no regional stress-induced ischemia or vessels not needing revascularization (P < 0.001). In 4 of 123 vessel territories with stress-induced ischemia by CMR, PET showed a normal MFR. In addition, 12 of 123 vessels that underwent intervention showed normal MFR assessed by PET. Conclusion The limited performance of qualitative assessment of presence of stable CAD with CMR and CA, when related to quantitative 13N-NH3 cardiac PET, shows the need for fully quantitative assessment of myocardial perfusion and the use of invasive flow reserve measurements for CA, to confirm the need of elective revascularization.

Steady-state free precession sequences in myocardial first-pass perfusion MR imaging: comparison with TurboFLASH imaging

2004 ◽  
Vol 14 (3) ◽  
pp. 409-416 ◽  
Author(s):  
Peter Hunold ◽  
Stefan Maderwald ◽  
Holger Eggebrecht ◽  
Florian M. Vogt ◽  
J�rg Barkhausen
Keyword(s):  
Steady State ◽  
Mr Imaging ◽  
Steady State Free Precession ◽  
Free Precession ◽  
Pass Perfusion ◽  
First Pass ◽  
Perfusion Mr ◽  
Perfusion Mr Imaging ◽  
First Pass Perfusion

scholarly journals The quantitative assessment of microvascular obstruction size using first-pass perfusion cardiac MR

2011 ◽  
Vol 13 (S1) ◽  
Author(s):  
Yoko Mikami ◽  
Andreas Kumar ◽  
Vanessa M Ferreira ◽  
Mouhieddin Traboulsi ◽  
Todd J Anderson ◽  
...  
Keyword(s):  
Quantitative Assessment ◽  
Microvascular Obstruction ◽  
Cardiac Mr ◽  
Pass Perfusion ◽  
First Pass ◽  
First Pass Perfusion

scholarly journals Accelerated dual-contrast first-pass perfusion MRI of the mouse heart: Development and application to diet-induced obese mice

2014 ◽  
Vol 73 (3) ◽  
pp. 1237-1245 ◽  
Author(s):  
Nivedita K. Naresh ◽  
Xiao Chen ◽  
Rene J. Roy ◽  
Patrick F. Antkowiak ◽  
Brian H. Annex ◽  
...  
Keyword(s):  
Heart Development ◽  
Perfusion Mri ◽  
Mouse Heart ◽  
Obese Mice ◽  
Pass Perfusion ◽  
First Pass ◽  
First Pass Perfusion
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