Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2complexed with indomethacin at 1.4 Å resolution reveals the presence of the new common ligand-binding site

2009 ◽  
Vol 22 (6) ◽  
pp. 437-445 ◽  
Author(s):  
Nagendra Singh ◽  
Ramasamy Prem Kumar ◽  
Sanjit Kumar ◽  
Sujata Sharma ◽  
Rafia Mir ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Binding Site ◽  
Ligand Binding Site ◽  
Simultaneous Inhibition

Structural analysis of the choline-binding protein ChoX in a semi-closed and ligand-free conformation

2009 ◽  
Vol 390 (11) ◽  
Author(s):  
Christine Oswald ◽  
Sander H.J. Smits ◽  
Marina Höing ◽  
Erhard Bremer ◽  
Lutz Schmitt
Keyword(s):  
Crystal Structure ◽  
Structural Analysis ◽  
Ligand Binding ◽  
Closed Form ◽  
Binding Site ◽  
Sinorhizobium Meliloti ◽  
Binding Protein ◽  
Ligand Binding Site ◽  
Abc Transport ◽  
Ligand Free

Abstract The periplasmic ligand-binding protein ChoX is part of the ABC transport system ChoVWX that imports choline as a nutrient into the soil bacterium Sinorhizobium meliloti. We have recently reported the crystal structures of ChoX in complex with its ligands choline and acetylcholine and the structure of a fully closed but substrate-free state of ChoX. This latter structure revealed an architecture of the ligand-binding site that is superimposable to the closed, ligand-bound form of ChoX. We report here the crystal structure of ChoX in an unusual, ligand-free conformation that represents a semi-closed form of ChoX. The analysis revealed a subdomain movement in the N-lobe of ChoX. Comparison with the two well-characterized substrate binding proteins, MBP and HisJ, suggests the presence of a similar subdomain in these proteins.

scholarly journals Prediction of a New Ligand-Binding Site for Type 2 Motif based on the Crystal Structure of ALG-2 by Dry and Wet Approaches

2012 ◽  
Vol 13 (6) ◽  
pp. 7532-7549 ◽  
Author(s):  
Takeshi Takahashi ◽  
Hironori Suzuki ◽  
Tatsutoshi Inuzuka ◽  
Hideki Shibata ◽  
Masatoshi Maki
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Binding Site ◽  
Ligand Binding Site

scholarly journals Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site

2015 ◽  
Vol 24 (3) ◽  
pp. 376-385 ◽  
Author(s):  
Yoshie Fujiwara ◽  
Natsuko Goda ◽  
Tomonari Tamashiro ◽  
Hirotaka Narita ◽  
Kaori Satomura ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Binding Site ◽  
Pdz Domain ◽  
Structural Plasticity ◽  
Ligand Binding Site

Crystal Structure of Human Complement Protein C8γ at 1.2 Å Resolution Reveals a Lipocalin Fold and a Distinct Ligand Binding Site†,‡

Biochemistry ◽  
2002 ◽  
Vol 41 (22) ◽  
pp. 7030-7037 ◽  
Author(s):  
Eric Ortlund ◽  
Chasta L. Parker ◽  
Steven F. Schreck ◽  
Steve Ginell ◽  
Wladek Minor ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Binding Site ◽  
Human Complement ◽  
Ligand Binding Site ◽  
Complement Protein

Constraints of Opsin Structure on the Ligand-binding Site: Studies with Ring-fused Retinals¶

2002 ◽  
Vol 76 (6) ◽  
pp. 606 ◽  
Author(s):  
Takahiro Hirano ◽  
In Taek Lim ◽  
Don Moon Kim ◽  
Xiang-Guo Zheng ◽  
Kazuo Yoshihara ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Binding Site ◽  
Ligand Binding Site
Sign in / Sign up

Export Citation Format

Share Document