Selection and combination of machine learning classifiers for prediction of linear B-cell epitopes on proteins

2006 ◽  
Vol 19 (3) ◽  
pp. 209-214 ◽  
Author(s):  
Johannes Söllner
Keyword(s):  
Machine Learning ◽  
B Cell ◽  
B Cell Epitopes ◽  
Machine Learning Classifiers ◽  
Learning Classifiers ◽  
Linear B

scholarly journals NIgPred: Class-Specific Antibody Prediction for Linear B-Cell Epitopes Based on Heterogeneous Features and Machine-Learning Approaches

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1531
Author(s):  
Chi-Hua Tung ◽  
Yi-Sheng Chang ◽  
Kai-Po Chang ◽  
Yen-Wei Chu
Keyword(s):  
Machine Learning ◽  
B Cell ◽  
Training Model ◽  
Hill Climbing ◽  
Learning Approaches ◽  
Data Set ◽  
B Cell Epitopes ◽  
Hill Climbing Algorithm ◽  
Allergen Detection ◽  
Linear B

Upon invasion by foreign pathogens, specific antibodies can identify specific foreign antigens and disable them. As a result of this ability, antibodies can help with vaccine production and food allergen detection in patients. Many studies have focused on predicting linear B-cell epitopes, but only two prediction tools are currently available to predict the sub-type of an epitope. NIgPred was developed as a prediction tool for IgA, IgE, and IgG. NIgPred integrates various heterologous features with machine-learning approaches. Differently from previous studies, our study considered peptide-characteristic correlation and autocorrelation features. Sixty kinds of classifier were applied to construct the best prediction model. Furthermore, the genetic algorithm and hill-climbing algorithm were used to select the most suitable features for improving the accuracy and reducing the time complexity of the training model. NIgPred was found to be superior to the currently available tools for predicting IgE epitopes and IgG epitopes on independent test sets. Moreover, NIgPred achieved a prediction accuracy of 100% for the IgG epitopes of a coronavirus data set. NIgPred is publicly available at our website.

scholarly journals Assessing the Effect of Training Sampling Design on the Performance of Machine Learning Classifiers for Land Cover Mapping Using Multi-Temporal Remote Sensing Data and Google Earth Engine

2021 ◽  
Vol 13 (8) ◽  
pp. 1433
Author(s):  
Shobitha Shetty ◽  
Prasun Kumar Gupta ◽  
Mariana Belgiu ◽  
S. K. Srivastav
Keyword(s):  
Machine Learning ◽  
Remote Sensing ◽  
Random Sampling ◽  
Sampling Design ◽  
Remote Sensing Data ◽  
Google Earth ◽  
Machine Learning Classifiers ◽  
Learning Classifiers ◽  
Multi Temporal ◽  
Google Earth Engine

Machine learning classifiers are being increasingly used nowadays for Land Use and Land Cover (LULC) mapping from remote sensing images. However, arriving at the right choice of classifier requires understanding the main factors influencing their performance. The present study investigated firstly the effect of training sampling design on the classification results obtained by Random Forest (RF) classifier and, secondly, it compared its performance with other machine learning classifiers for LULC mapping using multi-temporal satellite remote sensing data and the Google Earth Engine (GEE) platform. We evaluated the impact of three sampling methods, namely Stratified Equal Random Sampling (SRS(Eq)), Stratified Proportional Random Sampling (SRS(Prop)), and Stratified Systematic Sampling (SSS) upon the classification results obtained by the RF trained LULC model. Our results showed that the SRS(Prop) method favors major classes while achieving good overall accuracy. The SRS(Eq) method provides good class-level accuracies, even for minority classes, whereas the SSS method performs well for areas with large intra-class variability. Toward evaluating the performance of machine learning classifiers, RF outperformed Classification and Regression Trees (CART), Support Vector Machine (SVM), and Relevance Vector Machine (RVM) with a >95% confidence level. The performance of CART and SVM classifiers were found to be similar. RVM achieved good classification results with a limited number of training samples.

scholarly journals A review of infant cry analysis and classification

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Chunyan Ji ◽  
Thosini Bamunu Mudiyanselage ◽  
Yutong Gao ◽  
Yi Pan
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Signal Analysis ◽  
Future Research ◽  
Prosodic Features ◽  
Infant Cry ◽  
Machine Learning Classification ◽  
Machine Learning Classifiers ◽  
Learning Classifiers ◽  
Processing Techniques

AbstractThis paper reviews recent research works in infant cry signal analysis and classification tasks. A broad range of literatures are reviewed mainly from the aspects of data acquisition, cross domain signal processing techniques, and machine learning classification methods. We introduce pre-processing approaches and describe a diversity of features such as MFCC, spectrogram, and fundamental frequency, etc. Both acoustic features and prosodic features extracted from different domains can discriminate frame-based signals from one another and can be used to train machine learning classifiers. Together with traditional machine learning classifiers such as KNN, SVM, and GMM, newly developed neural network architectures such as CNN and RNN are applied in infant cry research. We present some significant experimental results on pathological cry identification, cry reason classification, and cry sound detection with some typical databases. This survey systematically studies the previous research in all relevant areas of infant cry and provides an insight on the current cutting-edge works in infant cry signal analysis and classification. We also propose future research directions in data processing, feature extraction, and neural network classification fields to better understand, interpret, and process infant cry signals.

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