Exploring the structural basis and atomistic binding mechanistic of the selective antagonist blockade at D 3 dopamine receptor over D 2 dopamine receptor

2021 ◽  
Author(s):  
Patrick Appiah‐Kubi ◽  
Fisayo Andrew Olotu ◽  
Mahmoud E. S. Soliman
Keyword(s):  
Dopamine Receptor ◽  
Structural Basis ◽  
Selective Antagonist

Structural Basis of Dopamine Receptor Activation

2009 ◽  
pp. 47-73 ◽  
Author(s):  
Irina S. Moreira ◽  
Lei Shi ◽  
Zachary Freyberg ◽  
Spencer S. Ericksen ◽  
Harel Weinstein ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Activation ◽  
Structural Basis

Structural Basis and Mechanism of Chiral Benzedrine Molecules Interacting With Third Dopamine Receptor

Chirality ◽  
2016 ◽  
Vol 28 (10) ◽  
pp. 674-685 ◽  
Author(s):  
Ming Wang ◽  
Wei Xie ◽  
Aijing Li ◽  
Sichuan Xu
Keyword(s):  
Dopamine Receptor ◽  
Structural Basis

The Effect of SV 293, a D2 Dopamine Receptor-Selective Antagonist, on D2 Receptor-Mediated GIRK Channel Activation and Adenylyl Cyclase Inhibition

Pharmacology ◽  
2013 ◽  
Vol 92 (1-2) ◽  
pp. 84-89 ◽  
Author(s):  
Renqi Huang ◽  
Suzy A. Griffin ◽  
Michelle Taylor ◽  
Suwanna Vangveravong ◽  
Robert H. Mach ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Dopamine Receptor ◽  
D2 Receptor ◽  
D2 Dopamine Receptor ◽  
Channel Activation ◽  
Selective Antagonist ◽  
Girk Channel

scholarly journals Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in rats

2009 ◽  
Vol 56 (6-7) ◽  
pp. 944-955 ◽  
Author(s):  
Rakesh Kumar ◽  
Lindsay Riddle ◽  
Suzy A. Griffin ◽  
Peter Grundt ◽  
Amy Hauck Newman ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Abnormal Involuntary Movements ◽  
Involuntary Movements ◽  
Selective Antagonist

Structural basis of species-selective antagonist binding to the succinate receptor

Nature ◽  
2019 ◽  
Vol 574 (7779) ◽  
pp. 581-585 ◽  
Author(s):  
Matthias Haffke ◽  
Dominique Fehlmann ◽  
Gabriele Rummel ◽  
Jacques Boivineau ◽  
Myriam Duckely ◽  
...  
Keyword(s):  
Structural Basis ◽  
Selective Antagonist ◽  
Antagonist Binding

scholarly journals Optimization of ML321: a D 2 dopamine receptor‐selective antagonist for the treatment of neuropsychiatric disorders

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Julia Rocereta ◽  
R. Free ◽  
Andres Dulcey Garcia ◽  
Noel Southall ◽  
Lei Shi ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Neuropsychiatric Disorders ◽  
Selective Antagonist

Structural Basis of NR2B-Selective Antagonist Recognition by N-Methyl-d-aspartate Receptors

2008 ◽  
Vol 75 (1) ◽  
pp. 60-74 ◽  
Author(s):  
Laetitia Mony ◽  
Lucie Krzaczkowski ◽  
Manuel Leonetti ◽  
Anne Le Goff ◽  
Karine Alarcon ◽  
...  
Keyword(s):  
Structural Basis ◽  
Selective Antagonist

Organization of tight junctions in the choroid plexus epithelium

1978 ◽  
Vol 36 (2) ◽  
pp. 336-337
Author(s):  
B. Van Deurs ◽  
J. K. Koehler
Keyword(s):  
Choroid Plexus ◽  
Present Report ◽  
Freeze Fracture ◽  
Barrier Properties ◽  
Cell Junctions ◽  
Structural Basis ◽  
Apical Surface ◽  
Choroid Plexus Epithelium ◽  
Solid Nitrogen ◽  
Special Composition

The choroid plexus epithelium constitutes a blood-cerebrospinal fluid (CSF) barrier, and is involved in regulation of the special composition of the CSF. The epithelium is provided with an ouabain-sensitive Na/K-pump located at the apical surface, actively pumping ions into the CSF. The choroid plexus epithelium has been described as “leaky” with a low transepithelial resistance, and a passive transepithelial flux following a paracellular route (intercellular spaces and cell junctions) also takes place. The present report describes the structural basis for these “barrier” properties of the choroid plexus epithelium as revealed by freeze fracture.Choroid plexus from the lateral, third and fourth ventricles of rats were used. The tissue was fixed in glutaraldehyde and stored in 30% glycerol. Freezing was performed either in liquid nitrogen-cooled Freon 22, or directly in a mixture of liquid and solid nitrogen prepared in a special vacuum chamber. The latter method was always used, and considered necessary, when preparations of complementary (double) replicas were made.

Sign in / Sign up

Export Citation Format

Share Document