Structure‐based discovery and redesign of TGF ‐β1 Elbow epitope recognition by its type‐II receptor in hypertrophic scarring biotherapy

2020 ◽  
Author(s):  
Xiaoting Chen ◽  
Huixiong Wang ◽  
Songlin Yang ◽  
Jianghong Zheng ◽  
Xiangdong Liu ◽  
...  
Keyword(s):  
Type Ii ◽  
Hypertrophic Scarring ◽  
Epitope Recognition ◽  
Tgf Β1

Regulation of extracellular matrix synthesis by TNF-α and TGF-β1 in type II cells exposed to coal dust

1998 ◽  
Vol 275 (4) ◽  
pp. L637-L644 ◽  
Author(s):  
Yu-Chen Lee ◽  
D. Eugene Rannels
Keyword(s):  
Extracellular Matrix ◽  
Cell Cultures ◽  
Transforming Growth Factor ◽  
Coal Dust ◽  
Transforming Growth Factor Β1 ◽  
Type Ii ◽  
Tnf Α ◽  
Type Ii Cell ◽  
Primary Type ◽  
Tgf Β1

Type II pulmonary epithelial cells respond to anthracite coal dust PSOC 867 with increased synthesis of extracellular matrix (ECM) components. Alveolar macrophages modulate this response by pathways that may involve soluble mediators, including tumor necrosis factor-α (TNF-α) or transforming growth factor-β1 (TGF-β1). The effects of TNF-α (10 ng/ml) and/or TGF-β1 (2 ng/ml) were thus investigated in dust-exposed primary type II cell cultures. In control day 1 or day 3 cultures, TNF-α and/or TGF-β1 had little or no effect on the synthesis of type II cellular proteins, independent of whether the cells were exposed to dust. With PSOC 867 exposure, where ECM protein synthesis is elevated, TNF-α and TGF-β1 further increased both the absolute and relative rates of ECM synthesis on day 3 but had little effect on day 1. Each mediator increased expression of fibronectin mRNA, as well as of ECM fibronectin content, in a manner qualitatively similar to their effects on synthesis. Thus TNF-α and TGF-β1 modulate both ECM synthesis and fibronectin content in coal dust-exposed type II cell cultures.

Expression of alpha-smooth muscle actin, TGF-β1 and TGF-β type II receptor during connective tissue contraction

1997 ◽  
Vol 33 (8) ◽  
pp. 622-627 ◽  
Author(s):  
M. Reza Ghassemifar ◽  
Roy W. Tarnuzzer ◽  
Nasser Chegini ◽  
Erkki Tarpila ◽  
Gregory S. Schultz ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Connective Tissue ◽  
Smooth Muscle Actin ◽  
Type Ii ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Tissue Contraction ◽  
Tgf Β1

scholarly journals Estrogen induces apoptosis in a rat prostatic adenocarcinoma: Association with an increased expression of TGF- β1 and its type-I and type-II receptors

1996 ◽  
Vol 67 (4) ◽  
pp. 573-579 ◽  
Author(s):  
Maréne Landström ◽  
Solveig Eklöv ◽  
Pascal Colosetti ◽  
Sten Nilsson ◽  
Jan-Erik Damber ◽  
...  
Keyword(s):  
Prostatic Adenocarcinoma ◽  
Type I ◽  
Type Ii ◽  
Tgf Β1

Cigarette smoke extract induces apoptosis of rat alveolar Type II cells via the PLTP/TGF-β1/Smad2 pathway

2015 ◽  
Vol 28 (1) ◽  
pp. 707-714 ◽  
Author(s):  
Hong Chen ◽  
Ke Liao ◽  
Lv Cui-Zhao ◽  
Fu Qiang-Wen ◽  
Xue Feng-Zeng ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Cigarette Smoke Extract ◽  
Alveolar Type ◽  
Type Ii Cells ◽  
Type Ii ◽  
Alveolar Type Ii Cells ◽  
Tgf Β1

scholarly journals BMP-2 and TGF-β1 differentially control expression of type II procollagen and α10 and α11 integrins in mouse chondrocytes

2010 ◽  
Vol 89 (4) ◽  
pp. 307-314 ◽  
Author(s):  
Jérôme Gouttenoire ◽  
Carole Bougault ◽  
Elisabeth Aubert-Foucher ◽  
Emeline Perrier ◽  
Marie-Claire Ronzière ◽  
...  
Keyword(s):  
Type Ii ◽  
Tgf Β1
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