Enhanced selectivity of a molecularly imprinted polymer toward the target molecule via esterification of non-specific binding sites with diazomethane

2014 ◽  
Vol 27 (12) ◽  
pp. 755-762 ◽  
Author(s):  
Noof A. Alenazi ◽  
Edward P. C. Lai ◽  
Jeffrey M. Manthorpe
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Specific Binding ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Target Molecule ◽  
Specific Binding Sites ◽  
Enhanced Selectivity

scholarly journals A Note about Crosslinking Density in Imprinting Polymerization

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5139
Author(s):  
Anja Mueller
Keyword(s):  
Literature Review ◽  
Binding Sites ◽  
Specific Binding ◽  
Crosslinking Density ◽  
Polymer Science ◽  
Imprinted Polymer ◽  
Science Data ◽  
Molecularly Imprinted ◽  
Specific Binding Sites ◽  
Factor Governing

Imprinting polymerization is an exciting technique since it leads to specific binding sites, which are the basis of a variety of applications, such as sensors, detectors, and catalysts. The specific binding sites are created using templates and then fixing the structure of the binding site with crosslinking. The literature review of imprinting polymerizations shows that the crosslinking density governs the physical properties of the resulting molecularly imprinted polymer (MIP). It is also a factor governing the capacity and the selectivity of MIPs. Reviewing polymer science data and theory, the crosslinking density commonly used in MIP synthesis is unusually high. The data reviewed here suggest that more research is needed to determine the optimal crosslinking density for MIPs.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

Synthesis and Evaluation of a Molecularly Imprinted Polymer Selective to 2,4,6-Trichlorophenol

2004 ◽  
Vol 57 (8) ◽  
pp. 759 ◽  
Author(s):  
Lachlan Schwarz ◽  
Clovia I. Holdsworth ◽  
Adam McCluskey ◽  
Michael C. Bowyer
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Competitive Binding ◽  
Imprinted Polymer ◽  
Binding Studies ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Target Molecule ◽  
High Preference ◽  
Structural Analogues

Molecularly imprinted polymers (MIPs) selective for the phenolic contaminant 2,4,6-trichlorophenol (2,4,6-TCP) were prepared and evaluated in three porogens of differing character (hexane, acetonitrile, dichloromethane). Rebinding of 2,4,6-TCP was found to be most effective in dichloromethane (imprinting factor: 13.2). Competitive binding studies performed against a range of close structural analogues showed a high preference for the target molecule, although partial recognition towards 2,4-dichlorophenol was also observed. Specificity was found to be dependent upon the presence of ring chlorine on the target, which suggested that these atoms participate in secondary binding interactions that are essential for successful recognition in the polymer cavity.

scholarly journals Molecularly Imprinted Polymer Microspheres Containing Photoswitchable Spiropyran-Based Binding Sites

2013 ◽  
Vol 5 (17) ◽  
pp. 8537-8545 ◽  
Author(s):  
Tibor Renkecz ◽  
Günter Mistlberger ◽  
Marcin Pawlak ◽  
Viola Horváth ◽  
Eric Bakker
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Polymer Microspheres ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Synthesis of Nimetazepam - Molecularly Imprinted Polymer and SPE Application

2013 ◽  
Vol 699 ◽  
pp. 200-206 ◽  
Author(s):  
Ling Zhi Sun ◽  
Cheng Jun Sun ◽  
Yong Qin Fang ◽  
Xian Xiang Sun
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Specific Binding ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Complex Samples ◽  
Similar Chemical ◽  
Dummy Template ◽  
And Performance ◽  
Related Compounds

The synthesis and performance of a molecularly imprinted polymer (MIP) designed to enable the clean-up of the interferences existing in alprazolam (Alpra) drug samples is described. The MIP was synthesized using non-covalent molecularly imprinted method. Nimetazepam (Nimet), which has a similar chemical structure as the major impurities in Alpra drug samples, was used as the dummy template. Methacrylic acid was used as the monomer. Both the affinity and selectivity of the MIP for Nimet and structurally related compounds were examined through batch-rebinding studies. The specific binding amount of Nimet was determined to be 11.4 mg•g-1. The MIP was used as the sorbent in solid phase extraction (MI-SPE) and methanol was used as the washing solvent for the clean-up of Nimet in the Alpra complex samples. The effective clean-up of Nimet was achieved, with a recovery > 90% for Alpra, in the stimulated samples.

Functional Patternings Fabricated using Molecularly Imprinted Polymer; Molecular Recognitions for Chemical Detection

2006 ◽  
Vol 951 ◽  
Author(s):  
Kyung Choi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Polymer System ◽  
Chemical Detection ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Micro Particles ◽  
Detection Technology ◽  
Receptor Sites ◽  
High Affinity Receptor

ABSTRACTWe present functional patterns fabricated using functional polymers. The functional polymer is MIP (molecularly imprinted polymer) system, which can be produced through “molecular imprinting” to create “synthetic receptor or binding sites” for bio/chemical detection technology. Those binding sites have specific molecular recognition functions for targeting organic or bio molecules. MIP's patterns in the micro-scale were fabricated for chemical sensors, diagonostic bio-sensors, and for drug delivery systems. We also obtained homogeneous MIP's micro-particles, which have high affinity receptor sites only using a microfluidic reactor.

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