The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

2013 ◽  
Vol 26 (10) ◽  
pp. 439-449 ◽  
Author(s):  
Tony Velkov
Keyword(s):  
Receptor Binding ◽  
Binding Pocket ◽  
Influenza B Virus ◽  
Influenza B ◽  
B Virus

Probing of the Receptor-Binding Sites of the H1 and H3 Influenza A and Influenza B Virus Hemagglutinins by Synthetic and Natural Sialosides

Virology ◽  
1993 ◽  
Vol 196 (1) ◽  
pp. 111-121 ◽  
Author(s):  
M.N. Matrosovich ◽  
A.S. Gambaryan ◽  
A.B. Tuzikov ◽  
N.E. Byramova ◽  
L.V. Mochalova ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Binding Sites ◽  
Influenza A ◽  
Influenza B Virus ◽  
Influenza B ◽  
B Virus

scholarly journals The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus

Virology ◽  
2014 ◽  
Vol 450-451 ◽  
pp. 71-83 ◽  
Author(s):  
Fengyun Ni ◽  
Innocent Nnadi Mbawuike ◽  
Elena Kondrashkina ◽  
Qinghua Wang
Keyword(s):  
Receptor Binding ◽  
Influenza B Virus ◽  
Influenza B ◽  
B Virus

scholarly journals Recurring Influenza B Virus Infections in Seals

2013 ◽  
Vol 19 (3) ◽  
pp. 511-512 ◽  
Author(s):  
Rogier Bodewes ◽  
Danny Morick ◽  
Gerrie de Mutsert ◽  
Nynke Osinga ◽  
Theo Bestebroer ◽  
...  
Keyword(s):  
Influenza B Virus ◽  
Influenza B ◽  
Virus Infections ◽  
B Virus

scholarly journals Molecular Epidemiology and Phylogenetic Analyses of Influenza B Virus in Thailand during 2010 to 2014

PLoS ONE ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. e0116302 ◽  
Author(s):  
Nipaporn Tewawong ◽  
Kamol Suwannakarn ◽  
Slinporn Prachayangprecha ◽  
Sumeth Korkong ◽  
Preeyaporn Vichiwattana ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Phylogenetic Analyses ◽  
Influenza B Virus ◽  
Influenza B ◽  
B Virus

scholarly journals Mutation E48K in PB1 Polymerase Subunit Improves Stability of a Candidate Live Attenuated Influenza B Virus Vaccine

Vaccines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 800
Author(s):  
Jongsuk Mo ◽  
Stivalis Cardenas-Garcia ◽  
Jefferson J. S. Santos ◽  
Lucas M. Ferreri ◽  
C. Joaquín Cáceres ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
The Elderly ◽  
Potential Interaction ◽  
Respiratory Pathogen ◽  
Influenza B Virus ◽  
Influenza B ◽  
Epitope Tag ◽  
Live Attenuated Vaccine ◽  
B Virus ◽  
Homologous Challenge

Influenza B virus (IBV) is a major respiratory pathogen of humans, particularly in the elderly and children, and vaccines are the most effective way to control it. In previous work, incorporation of two mutations (E580G, S660A) along with the addition of an HA epitope tag in the PB1 segment of B/Brisbane/60/2008 (B/Bris) resulted in an attenuated strain that was safe and effective as a live attenuated vaccine. A third attempted mutation (K391E) in PB1 was not always stable. Interestingly, viruses that maintained the K391E mutation were associated with the mutation E48K. To explore the contribution of the E48K mutation to stability of the K391E mutation, a vaccine candidate was generated by inserting both mutations, along with attenuating mutations E580G and S660A, in PB1 of B/Bris (B/Bris PB1att 4M). Serial passages of the B/Bris PB1att 4M vaccine candidate in eggs and MDCK indicated high stability. In silico structural analysis revealed a potential interaction between amino acids at positions 48 and 391. In mice, B/Bris PB1att 4M was safe and provided complete protection against homologous challenge. These results confirm the compensatory effect of mutation E48K to stabilize the K391E mutation, resulting in a safer, yet still protective, IBV LAIV vaccine.

Exploration of the emergence of the Victoria lineage of influenza B virus

2006 ◽  
Vol 152 (2) ◽  
pp. 415-422 ◽  
Author(s):  
J.-M. Chen ◽  
Y.-J. Guo ◽  
K.-Y. Wu ◽  
J.-F. Guo ◽  
M. Wang ◽  
...  
Keyword(s):  
Influenza B Virus ◽  
Influenza B ◽  
B Virus

Genetic and phenotypic analysis of reassortants of high growth and low growth strains of influenza B virus

Vaccine ◽  
2003 ◽  
Vol 21 (25-26) ◽  
pp. 3867-3874 ◽  
Author(s):  
G.M Vodeiko ◽  
J McInnis ◽  
V Chizhikov ◽  
R.A Levandowski
Keyword(s):  
High Growth ◽  
Influenza B Virus ◽  
Influenza B ◽  
Phenotypic Analysis ◽  
B Virus

Studies on the synthesis of the influenza B virus NB glycoprotein

Virology ◽  
1984 ◽  
Vol 139 (1) ◽  
pp. 178-184 ◽  
Author(s):  
Michael W. Shaw ◽  
Purnell W. Choppin
Keyword(s):  
Influenza B Virus ◽  
Influenza B ◽  
B Virus
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