A three-dimensional muscle model: A quantified relation between form and function of skeletal muscles

1984 ◽  
Vol 182 (1) ◽  
pp. 95-113 ◽  
Author(s):  
R. D. Woittiez ◽  
P. A. Huijing ◽  
H. B. K. Boom ◽  
R. H. Rozendal
Keyword(s):  
Skeletal Muscles ◽  
Three Dimensional ◽  
Muscle Model ◽  
Form And Function ◽  
And Function

scholarly journals Weighing trees with lasers: advances, challenges and opportunities

2018 ◽  
Vol 8 (2) ◽  
pp. 20170048 ◽  
Author(s):  
M. I. Disney ◽  
M. Boni Vicari ◽  
A. Burt ◽  
K. Calders ◽  
S. L. Lewis ◽  
...  
Keyword(s):  
Laser Scanning ◽  
Large Scale ◽  
Three Dimensional ◽  
Point Clouds ◽  
3D Models ◽  
Tree Form ◽  
Form And Function ◽  
Challenges And Opportunities ◽  
And Function ◽  
Non Destructive

Terrestrial laser scanning (TLS) is providing exciting new ways to quantify tree and forest structure, particularly above-ground biomass (AGB). We show how TLS can address some of the key uncertainties and limitations of current approaches to estimating AGB based on empirical allometric scaling equations (ASEs) that underpin all large-scale estimates of AGB. TLS provides extremely detailed non-destructive measurements of tree form independent of tree size and shape. We show examples of three-dimensional (3D) TLS measurements from various tropical and temperate forests and describe how the resulting TLS point clouds can be used to produce quantitative 3D models of branch and trunk size, shape and distribution. These models can drastically improve estimates of AGB, provide new, improved large-scale ASEs, and deliver insights into a range of fundamental tree properties related to structure. Large quantities of detailed measurements of individual 3D tree structure also have the potential to open new and exciting avenues of research in areas where difficulties of measurement have until now prevented statistical approaches to detecting and understanding underlying patterns of scaling, form and function. We discuss these opportunities and some of the challenges that remain to be overcome to enable wider adoption of TLS methods.

scholarly journals Quantitative analysis of subcellular distributions with an open-source, object-based tool

Biology Open ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. bio055228 ◽  
Author(s):  
Pearl V. Ryder ◽  
Dorothy A. Lerit
Keyword(s):  
Image Analysis ◽  
Open Source ◽  
Three Dimensional ◽  
Analysis Data ◽  
Form And Function ◽  
Object Based Image Analysis ◽  
Object Based ◽  
And Function ◽  
Microscopy Images ◽  
Complete Process

ABSTRACTThe subcellular localization of objects, such as organelles, proteins, or other molecules, instructs cellular form and function. Understanding the underlying spatial relationships between objects through colocalization analysis of microscopy images is a fundamental approach used to inform biological mechanisms. We generated an automated and customizable computational tool, the SubcellularDistribution pipeline, to facilitate object-based image analysis from three-dimensional (3D) fluorescence microcopy images. To test the utility of the SubcellularDistribution pipeline, we examined the subcellular distribution of mRNA relative to centrosomes within syncytial Drosophila embryos. Centrosomes are microtubule-organizing centers, and RNA enrichments at centrosomes are of emerging importance. Our open-source and freely available software detected RNA distributions comparably to commercially available image analysis software. The SubcellularDistribution pipeline is designed to guide the user through the complete process of preparing image analysis data for publication, from image segmentation and data processing to visualization.This article has an associated First Person interview with the first author of the paper.

scholarly journals Virtual paleontology: computer-aided analysis of fossil form and function

2014 ◽  
Vol 88 (4) ◽  
pp. 633-635 ◽  
Author(s):  
Imran A. Rahman ◽  
Selena Y. Smith
Keyword(s):  
Imaging Techniques ◽  
Three Dimensional ◽  
Fossil Plants ◽  
Element Analysis ◽  
X Ray ◽  
Form And Function ◽  
Wide Range ◽  
History Of ◽  
Micro Tomography ◽  
And Function

‘Virtual paleontology’ entails the use of computational methods to assist in the three-dimensional (3-D) visualization and analysis of fossils, and has emerged as a powerful approach for research on the history of life. Three-dimensional imaging techniques allow poorly understood or previously unknown anatomies of fossil plants, invertebrates, and vertebrates, as well as microfossils and trace fossils, to be described in much greater detail than formerly possible, and are applicable to a wide range of preservation types and specimen sizes (Table 1). These methods include non-destructive high-resolution scanning technologies such as conventional X-ray micro-tomography and synchrotron-based X-ray tomography. In addition, form and function can be rigorously investigated through quantitative analysis of computer models, for example finite-element analysis.

scholarly journals Under pressure: the relationship between cranial shape and burrowing force in caecilians (Gymnophiona)

2021 ◽  
Author(s):  
Aurélien Lowie ◽  
Barbara De Kegel ◽  
Mark Wilkinson ◽  
John Measey ◽  
James C. O'Reilly ◽  
...  
Keyword(s):  
Phylogenetic Signal ◽  
Three Dimensional ◽  
Form And Function ◽  
Biomechanical Models ◽  
Cranial Osteology ◽  
Head Morphology ◽  
And Function ◽  
The Relationship ◽  
Cranial Shape

Caecilians are elongate, limbless, and annulated amphibians that, with the exception of one aquatic family, all have an at least partly fossorial lifestyle. It has been suggested that caecilian evolution resulted in sturdy and compact skulls with fused bones and tight sutures, as an adaptation to their head-first burrowing habits. However, although their cranial osteology is well described, relationships between form and function remain poorly understood. In the present study, we explored the relationship between cranial shape and in vivo burrowing forces. Using µCT-data, we performed three-dimensional geometric morphometrics to explore whether cranial and mandibular shapes reflected patterns that might be associated with maximal push forces. The results highlight important differences in maximal push forces, with the aquatic Typhlonectes producing a lower force for a given size compared to other species. Despite substantial differences in head morphology across species, no relation between overall skull shape and push force could be detected. Although a strong phylogenetic signal may partly obscure the results, our conclusions confirm previous studies using biomechanical models and suggest that differences in the degree of fossoriality do not appear to be driving the evolution of head shape.

scholarly journals Form and Function in the Platyrrhine Skull: A Three-Dimensional Analysis of Dental and TMJ Morphology

2014 ◽  
Vol 298 (1) ◽  
pp. 29-47 ◽  
Author(s):  
Claire E. Terhune ◽  
Siobhán B. Cooke ◽  
Erik Otárola-Castillo
Keyword(s):  
Dimensional Analysis ◽  
Three Dimensional ◽  
Form And Function ◽  
And Function ◽  
Tmj Morphology

The heterodonty of Albertosaurus sarcophagus and Tyrannosaurus rex: biomechanical implications inferred through 3-D modelsThis article is one of a series of papers published in this Special Issue on the theme Albertosaurus.

2010 ◽  
Vol 47 (9) ◽  
pp. 1253-1261 ◽  
Author(s):  
Miriam Reichel
Keyword(s):  
Stress Distribution ◽  
Yield Criterion ◽  
Three Dimensional ◽  
Ct Scanning ◽  
Distribution Patterns ◽  
Shear Stresses ◽  
Form And Function ◽  
Southern Alberta ◽  
Tooth Form ◽  
And Function

The objective of this study is to analyze how different crown morphologies and different root lengths respond to stresses generated by the bite forces of Albertosaurus sarcophagus and Tyrannosaurus rex . Six well-preserved teeth of A. sarcophagus from the Albertosaurus bonebed in Dry Island Park (southern Alberta) were selected to study their biomechanics, and T. rex teeth were included for comparison. The three-dimensional (3-D) models were obtained through computerized tomography (CT) scanning and 3-D digitizing. Finite element analyses were performed in Strand7®. Bite forces for Albertosaurus and Tyrannosaurus were calculated based on cranial and jaw proportions. The results were viewed with the Tresca yield criterion. The ratios of shear stresses observed along the mesio-distal versus labio-lingual axes of all models allows the identification of similar stress distribution patterns in the upper and lower jaws of Albertosaurus and the upper jaws of Tyrannosaurus, with a higher amount of shear along the mesio-distal axis occurring in the mid-maxillary teeth. The dentary teeth of Tyrannosaurus, however, show a different stress distribution pattern, with a higher amount of shear occurring along the labio-lingual axis of the mid-dentary teeth. These differences in jaw mechanics suggest that the function of teeth in the lower jaw of Tyrannosaurus shifted a few positions to compensate different proportions in the dentary that cause the anterior dentary teeth to be aligned with the largest maxillary teeth in Tyrannosaurus. These results suggest that heterodonty in these groups is different and that tooth form and function are sensitive to jaw proportions.

scholarly journals Free and Forced Vibration Modes of the Human Fingertip

2021 ◽  
Vol 11 (12) ◽  
pp. 5709
Author(s):  
Gokhan Serhat ◽  
Katherine J. Kuchenbecker
Keyword(s):  
Forced Vibration ◽  
Three Dimensional ◽  
Element Model ◽  
Vibration Modes ◽  
Form And Function ◽  
Dimensional Finite Element ◽  
Deformable Bodies ◽  
Vibration Responses ◽  
Three Dimensional Finite Element ◽  
And Function

Computational analysis of free and forced vibration responses provides crucial information on the dynamic characteristics of deformable bodies. Although such numerical techniques are prevalently used in many disciplines, they have been underutilized in the quest to understand the form and function of human fingers. We addressed this opportunity by building DigiTip, a detailed three-dimensional finite element model of a representative human fingertip that is based on prior anatomical and biomechanical studies. Using the developed model, we first performed modal analyses to determine the free vibration modes with associated frequencies up to about 250 Hz, the frequency at which humans are most sensitive to vibratory stimuli on the fingertip. The modal analysis results reveal that this typical human fingertip exhibits seven characteristic vibration patterns in the considered frequency range. Subsequently, we applied distributed harmonic forces at the fingerprint centroid in three principal directions to predict forced vibration responses through frequency-response analyses; these simulations demonstrate that certain vibration modes are excited significantly more efficiently than the others under the investigated conditions. The results illuminate the dynamic behavior of the human fingertip in haptic interactions involving oscillating stimuli, such as textures and vibratory alerts, and they show how the modal information can predict the forced vibration responses of the soft tissue.

scholarly journals Quantifying Vascular Density in Tissue Engineered Constructs Using Machine Learning

2021 ◽  
Vol 12 ◽  
Author(s):  
Hannah A. Strobel ◽  
Alex Schultz ◽  
Sarah M. Moss ◽  
Rob Eli ◽  
James B. Hoying
Keyword(s):  
Machine Learning ◽  
Three Dimensional ◽  
Vascular Density ◽  
Form And Function ◽  
Tissue Constructs ◽  
Automated Method ◽  
Frequent Monitoring ◽  
Ideal Tool ◽  
Engineered Tissue ◽  
And Function

Given the considerable research efforts in understanding and manipulating the vasculature in tissue health and function, making effective measurements of vascular density is critical for a variety of biomedical applications. However, because the vasculature is a heterogeneous collection of vessel segments, arranged in a complex three-dimensional architecture, which is dynamic in form and function, it is difficult to effectively measure. Here, we developed a semi-automated method that leverages machine learning to identify and quantify vascular metrics in an angiogenesis model imaged with different modalities. This software, BioSegment, is designed to make high throughput vascular density measurements of fluorescent or phase contrast images. Furthermore, the rapidity of assessments makes it an ideal tool for incorporation in tissue manufacturing workflows, where engineered tissue constructs may require frequent monitoring, to ensure that vascular growth benchmarks are met.

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