scholarly journals Effectiveness of early hematopoietic stem cell transplantation in preventing neurocognitive decline in aspartylglucosaminuria: A case series

JIMD Reports ◽  
2021 ◽  
Author(s):  
Arthavan Selvanathan ◽  
Jane Kinsella ◽  
Francesca Moore ◽  
Robert Wynn ◽  
Simon Jones ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Case Series ◽  
Hematopoietic Stem ◽  
Neurocognitive Decline

scholarly journals A Case Series and Literature Review of Isavuconazole Use in Pediatric Patients with Hemato-oncologic Diseases and Hematopoietic Stem Cell Transplantation

2019 ◽  
Vol 64 (3) ◽  
Author(s):  
N. Decembrino ◽  
K. Perruccio ◽  
M. Zecca ◽  
A. Colombini ◽  
E. Calore ◽  
...  
Keyword(s):  
Body Weight ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Case Series ◽  
European Organization ◽  
Hematopoietic Stem ◽  
Oncologic Diseases

ABSTRACT We analyzed the use of isavuconazole (ISA) as treatment or prophylaxis for invasive fungal disease (IFD) in children with hemato-oncologic diseases. A multicentric retrospective analysis was performed among centers belonging to the Italian Association for Pediatric Hematology and Oncology (AIEOP). Pharmacokinetic (PK) monitoring was applied by a high-performance liquid chromatography-tandem mass spectrometry (HLPC-MS/MS) assay. Twenty-nine patients were studied: 10 during chemotherapy and 19 after allogeneic hematopoietic stem cell transplantation (HSCT). The patients consisted of 20 males and 9 females with a median age of 14.5 years (age range, 3 to 18 years) and a median body weight of 47 kg (body weight range, 15 to 80 kg). ISA was used as prophylaxis in 5 patients and as treatment in 24 cases (20 after therapeutic failure, 4 as first-line therapy). According to European Organization for Research and Treatment of Cancer (EORTC) criteria, we registered 5 patients with proven IFD, 9 patients with probable IFD, and 10 patients with possible IFD. Patients with a body weight of <30 kg received half the ISA dose; the others received ISA on the adult schedule (a 200-mg loading dose every 8 h on days 1 and 2 and a 200-mg/day maintenance dose); for all but 10 patients, the route of administration switched from the intravenous route to the oral route during treatment. ISA was administered for a median of 75.5 days (range, 6 to 523 days). The overall response rate was 70.8%; 12 patients with IFD achieved complete remission, 5 achieved partial remission, 5 achieved progression, and 3 achieved stable IFD. No breakthrough infections were registered. PK monitoring of 17 patients revealed a median ISA steady-state trough concentration of 4.91 mg/liter (range, 2.15 to 8.54 mg/liter) and a concentration/dose (in kilograms) ratio of 1.13 (range, 0.47 to 3.42). Determination of the 12-h PK profile was performed in 6 cases. The median area under the concentration-time curve from 0 to 12 h was 153.16 mg·h/liter (range, 86.31 to 169.45 mg·h/liter). Common Terminology Criteria for Adverse Events grade 1 to 3 toxicity (increased transaminase and/or creatinine levels) was observed in 6 patients, with no drug-drug interactions being seen in patients receiving immunosuppressants. Isavuconazole may be useful and safe in children with hemato-oncologic diseases, even in the HSCT setting. Prospective studies are warranted.

A case-series of Toxoplasmosis in hematopoietic stem cell transplantation: still a concern for endemic countries

2018 ◽  
Vol 53 (10) ◽  
pp. 1336-1339 ◽  
Author(s):  
Daniel P. Prestes ◽  
Clara Mendes ◽  
Marjorie V. Batista ◽  
Jéssica F. Ramos ◽  
Jayr Schimidt Junior ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Case Series ◽  
Hematopoietic Stem

scholarly journals Outcome of domino hematopoietic stem cell transplantation in human subjects: An international case series

2018 ◽  
Vol 142 (5) ◽  
pp. 1628-1631.e4 ◽  
Author(s):  
Mirjam E. Belderbos ◽  
Andrew R. Gennery ◽  
Christopher C. Dvorak ◽  
Henric-Jan Blok ◽  
Dirk-Jan Eikema ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Human Subjects ◽  
Case Series ◽  
Hematopoietic Stem

scholarly journals A case series of medication‐related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia

2020 ◽  
Author(s):  
Bárbara Soldatelli Ballardin ◽  
Rafael Zancan Mobile ◽  
Fábio Luiz Coracin ◽  
Lisandro Lima Ribeiro ◽  
Carmem Maria Sales Bonfim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Fanconi Anemia ◽  
Case Series ◽  
Hematopoietic Stem

scholarly journals Thrombotic obstruction of the central venous catheter in patients undergoing hematopoietic stem cell transplantation

2012 ◽  
Vol 20 (4) ◽  
pp. 804-812 ◽  
Author(s):  
Kátia Michelli Bertoldi Arone ◽  
Cleyton Zanardo de Oliveira ◽  
Lívia Maria Garbin ◽  
Paula Elaine Diniz dos Reis ◽  
Cristina Maria Galvão ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Case Series ◽  
Venous Catheter ◽  
Prevention Measures ◽  
Central Venous ◽  
Hematopoietic Stem

This is an integrative literature review with the aim of summarizing the prevention measures and treatment of thrombotic obstruction of long-term semi-implanted central venous catheters, in patients undergoing hematopoietic stem cell transplantation. The sample consisted of seven studies, being two randomized controlled clinical trials, three cohort studies and two case series. Regarding the prevention measures, one single study demonstrated effectiveness, which was a cohort study on the oral use of warfarin. In relation to the treatment measures, three studies evidenced effectiveness, one highlighted the efficacy of streptokinase or urokinase, one demonstrated the benefit of using low-molecular-weight heparin and the other treated the obstruction with heparin or urokinase. Catheter patency research shows a restricted evolution that does not follow the evolution of transplantations, mainly regarding nursing care.

Sign in / Sign up

Export Citation Format

Share Document