scholarly journals Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes

2000 ◽  
Vol 67 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Ewa Kontny ◽  
Mariola Kurowska ◽  
Katarzyna Szczepańska ◽  
Wodzimierz Maśliński
Keyword(s):  
Cytokine Production ◽  
Selective Inhibitor ◽  
Human Monocytes ◽  
Signaling Events

scholarly journals Antifungal antibiotics modulate the pro-inflammatory cytokine production and phagocytic activity of human monocytes in an in vitro sepsis model

Life Sciences ◽  
2015 ◽  
Vol 141 ◽  
pp. 128-136 ◽  
Author(s):  
Stefan Muenster ◽  
Christian Bode ◽  
Britta Diedrich ◽  
Sebastian Jahnert ◽  
Christina Weisheit ◽  
...  
Keyword(s):  
Phagocytic Activity ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Human Monocytes ◽  
Inflammatory Cytokine Production ◽  
Sepsis Model ◽  
Antifungal Antibiotics

scholarly journals A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

2011 ◽  
Vol 7 (1) ◽  
pp. e1001248 ◽  
Author(s):  
Christian Klotz ◽  
Thomas Ziegler ◽  
Ana Sofia Figueiredo ◽  
Sebastian Rausch ◽  
Matthew R. Hepworth ◽  
...  
Keyword(s):  
Cytokine Production ◽  
Signaling Events ◽  
Host Signaling

scholarly journals Bovine glycomacropeptide induces cytokine production in human monocytes through the stimulation of the MAPK and the NF-κB signal transduction pathways

2009 ◽  
Vol 157 (7) ◽  
pp. 1232-1240 ◽  
Author(s):  
Pilar Requena ◽  
Abdelali Daddaoua ◽  
Emilia Guadix ◽  
Antonio Zarzuelo ◽  
María Dolores Suárez ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cytokine Production ◽  
Signal Transduction Pathways ◽  
Human Monocytes ◽  
Stimulation Of

scholarly journals Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

2009 ◽  
Vol 15 (11) ◽  
pp. 1333-1333 ◽  
Author(s):  
Tony Muchamuel ◽  
Michael Basler ◽  
Monette A Aujay ◽  
Erika Suzuki ◽  
Khalid W Kalim ◽  
...  
Keyword(s):  
Cytokine Production ◽  
Selective Inhibitor ◽  
Experimental Arthritis

scholarly journals Regulation of Cellular Metabolism and Cytokines by the Medicinal Herb Feverfew in the Human Monocytic THP-1 Cells

2009 ◽  
Vol 6 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Chin-Fu Chen ◽  
Chun-Huai Cheng
Keyword(s):  
Cytokine Production ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Cellular Metabolism ◽  
Mechanisms Of Action ◽  
Human Monocytes ◽  
Cellular Targets ◽  
Tnf Α ◽  
Folk Remedy ◽  
Mediate Metabolism

The herb feverfew is a folk remedy for various symptoms including inflammation. Inflammation has recently been implicated in the genesis of many diseases including cancers, atherosclerosis and rheumatoid arthritis. The mechanisms of action of feverfew in the human body are largely unknown. To determine the cellular targets of feverfew extracts, we have utilized oligo microarrays to study the gene expression profiles elicited by feverfew extracts in human monocytic THP-1 cells. We have identified 400 genes that are consistently regulated by feverfew extracts. Most of the genes are involved in cellular metabolism. However, the genes undergoing the highest degree of change by feverfew treatment are involved in other pathways including chemokine function, water homeostasis and heme-mediated signaling. Our results also suggest that feverfew extracts effectively reduce Lipopolysaccharides (LPS)-mediated TNF-α and CCL2 (MCP-1) releases by THP-1 cells. We hypothesize that feverfew components mediate metabolism, cell migration and cytokine production in human monocytes/macrophages.

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