Elevated TNF-α and inducible nitric oxide production by alveolar macrophages after exposure to a nitrite inhalant

1996 ◽  
Vol 60 (4) ◽  
pp. 459-464 ◽  
Author(s):  
Lee S. F. Soderberg ◽  
Louis W. Chang ◽  
John B. Barnett
Keyword(s):  
Nitric Oxide ◽  
Alveolar Macrophages ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Tnf Α ◽  
Inducible Nitric Oxide

Diverse effects of docetaxel on inducible nitric oxide production in alveolar macrophages

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
I Wakabayashi ◽  
F Saito ◽  
S Matsusaka ◽  
Y Takahashi ◽  
M Poteser ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Alveolar Macrophages ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Inducible Nitric Oxide

scholarly journals LPS-Induced Formation of Immunoproteasomes: TNF-α and Nitric Oxide Production are Regulated by Altered Composition of Proteasome-Active Sites

2011 ◽  
Vol 60 (1-2) ◽  
pp. 77-88 ◽  
Author(s):  
Julia Reis ◽  
Xiu Qin Guan ◽  
Alexei F. Kisselev ◽  
Christopher J. Papasian ◽  
Asaf A. Qureshi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Active Sites ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Tnf Α

Evidence for Endogenous C1q Modulates TNF-α Receptor Synthesis and Autocrine Binding of TNF-α Associated with Lipid A Activation of Murine Macrophages for Nitric Oxide Production

1996 ◽  
Vol 170 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Hong Jiang ◽  
John A. Rummage ◽  
Charles A. Stewart ◽  
Mary J. Herriott ◽  
Irina Kolosova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lipid A ◽  
Nitric Oxide Production ◽  
Murine Macrophages ◽  
Oxide Production ◽  
Tnf Α

scholarly journals Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase.

1995 ◽  
Vol 181 (1) ◽  
pp. 63-70 ◽  
Author(s):  
N K Worrall ◽  
W D Lazenby ◽  
T P Misko ◽  
T S Lin ◽  
C P Rodi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Biologically Active ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The role of nitric oxide in the immune response to allogeneic tissue was explored in an in vivo cardiac transplant model in the rat. Nitric oxide production during organ rejection was demonstrated by elevations in systemic serum nitrite/nitrate levels and by electron paramagnetic resonance spectroscopy. Messenger RNA for the inducible nitric oxide synthase enzyme was detected in the rejecting allografted heart, but not in the nonrejecting isografted heart. The enzyme was demonstrated to be biologically active by the in vitro conversion of L-arginine to L-citrulline and was immunohistochemically localized to the infiltrating inflammatory cells. Treatment with aminoguanidine, a preferential inhibitor of the inducible nitric oxide synthase isoform, prevented the increased nitric oxide production in the transplanted organ and significantly attenuated the pathogenesis of acute rejection. Aminoguanidine treatment prolonged graft survival, improved graft contractile function, and significantly reduced the histologic grade of rejection. These results suggest an important role for nitric oxide in mediating the immune response to allogeneic tissue. Inhibition of inducible nitric oxide synthase may provide a novel therapeutic modality in the management of acute transplant rejection and of other immune-mediated processes.

Sign in / Sign up

Export Citation Format

Share Document