scholarly journals Differentiated service delivery for people using second‐line antiretroviral therapy: clinical outcomes from a retrospective cohort study in KwaZulu‐Natal, South Africa

2021 ◽  
Vol 24 (S6) ◽  
Author(s):  
Lara Lewis ◽  
Yukteshwar Sookrajh ◽  
Kelly Gate ◽  
Thokozani Khubone ◽  
Munthra Maraj ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Antiretroviral Therapy ◽  
Service Delivery ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Second Line ◽  
Differentiated Service ◽  
Kwazulu Natal ◽  
Second Line Antiretroviral Therapy

scholarly journals Determinants of Survival Among HIV/AIDS Patients With The Second-Line Antiretroviral Therapy In Henan Province of China 

2021 ◽  
Author(s):  
Yantao Jin ◽  
Miao Zhang ◽  
Yan-min Ma ◽  
Hui-jun Guo ◽  
Peng-yu Li ◽  
...  
Keyword(s):  
Cohort Study ◽  
Antiretroviral Therapy ◽  
Retrospective Cohort Study ◽  
Highly Active Antiretroviral Therapy ◽  
Retrospective Cohort ◽  
Cox Regression ◽  
Second Line ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Hiv Aids

Abstract Background: To estimate the survival and effectors of mortality among HIV/AIDS patients switch to second-line highly active antiretroviral therapy (ART) in rural China.Methods: A three years’ retrospective cohort study was conducted and HIV/AIDS patients switched to the second-line ART between January 2009 to December 2014 enrollment. The data collected from medical records and analysis using Kaplan-Meier statistics and COX regression models.Findings: A total of 2883 HIV/AIDS participants followed up for 8445 person-years, 183 (6.5%) died, 14(0.5%) lost follow-up and the mortality rate 2.17/100 person-years. After adjusting other confounding factors by multivariable COX regression, age older than 50 years (HR,3.37; 95%CI, 1.92-5.92), Traditional Chinese medicine therapy (HR,0.48; 95%CI, 0.33-0.71), CD4 cell count littler than 200 cells/μl (HR,2.97; 95%CI, 1.90-4.64), AST or ALT higher than 50 u/L (HR,1.55; 95%CI, 1.15-2.11) were each independently associated with mortality among HIV/AIDS patients switch to second-line ART.Conclusions: Our retrospective cohort study indicates that mortality among HIV/AIDS patients switch to second-line ART lower than most other studies. However, the limitations of a retrospective cohort could have biased the study, so prospective studies should be carried out to confirm our primary results. The result of our study suggest that Chinese therapy was potential treatment for HIV/AIDS patients.

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