scholarly journals Imperfect adherence in real life: a prevention‐effective perspective on adherence to daily and event‐driven HIV pre‐exposure prophylaxis among men who have sex with men – a prospective cohort study in Taiwan

2021 ◽  
Vol 24 (5) ◽  
Author(s):  
Huei‐Jiuan Wu ◽  
Stephane Wen‐Wei Ku ◽  
Howard H. Chang ◽  
Chia‐Wen Li ◽  
Nai‐Ying Ko ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Real Life ◽  
Event Driven ◽  
Sex With Men ◽  
Exposure Prophylaxis

Incidence and duration of incident oropharyngeal gonorrhoea and chlamydia infections among men who have sex with men: prospective cohort study

2020 ◽  
pp. sextrans-2020-054764 ◽  
Author(s):  
Eric P F Chow ◽  
Lenka A Vodstrcil ◽  
Deborah A Williamson ◽  
Kate Maddaford ◽  
Jane S Hocking ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Median Duration ◽  
Prospective Cohort ◽  
Nucleic Acid Amplification ◽  
Oropharyngeal Infection ◽  
Duration Of Infection ◽  
Sex With Men ◽  
Exposure Prophylaxis

ObjectivesThis prospective cohort study aimed to determine the natural history and incidence of oropharyngeal gonorrhoea and chlamydia among a cohort of men who have sex with men (MSM) over a 12-week period, and to examine risk factors associated with incident oropharyngeal infections.MethodsMSM either aged ≥18 years and had a diagnosis of oropharyngeal gonorrhoea by nucleic acid amplification test (NAAT) in the past 3 months or aged 18–35 years who were HIV-negative taking pre-exposure prophylaxis (PrEP) were eligible for this study. Enrolled men were followed up for 12 weeks. Oropharyngeal swabs were collected at week 0 (baseline) and week 12 (end of study). Between these time points, weekly saliva specimens and the number of tongue kissing, penile–oral and insertive rimming partners were collected by post. Oropharyngeal swabs and saliva specimens were tested by NAAT for Neisseria gonorrhoeae and Chlamydia trachomatis. Poisson regression was performed to examine the risk factors (weekly number of partners) associated with incident oropharyngeal gonorrhoea.ResultsA total of 100 MSM were recruited. The incidence of oropharyngeal gonorrhoea and chlamydia was 62 (95% CI 37 to 105) and 9 (95% CI 2 to 35)/100 person-years, respectively. The median duration of incident oropharyngeal infection with gonorrhoea was 28 days (IQR=21–36, n=7). The incidence rate ratio (IRR) for oropharyngeal gonorrhoea increased with an increased number of kissing partners (IRR=1.08; 95% CI 1.03 to 1.12) an increased number of penile-oral sex partners (IRR=1.07, 95% CI 1.01 to 1.14) but not with an increased number of insertive rimming partners (IRR=1.11, 95% CI 0.96 to 1.29) or other demographic factors. The IRR and duration of incident oropharyngeal chlamydia were not calculated due to the small number of cases (n=2).ConclusionsMSM have a high incidence of oropharyngeal gonorrhoea and the median duration of infection was less than 3 months.

scholarly journals Adherence to pre-exposure prophylaxis among men who have sex with men: A prospective cohort study

2018 ◽  
Vol 75 ◽  
pp. 52-59 ◽  
Author(s):  
Dou Qu ◽  
Xiaoni Zhong ◽  
Guiyuan Xiao ◽  
Jianghong Dai ◽  
Hao Liang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Sex With Men ◽  
Exposure Prophylaxis

Triple site sexually transmitted infection testing as a crucial component of surveillance for men who have sex with men: A prospective cohort study

2021 ◽  
pp. 095646242110474
Author(s):  
Roy Zucker ◽  
Michael Gaisa ◽  
Keith Sigel ◽  
Ilan Singer ◽  
Amos Adler ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Study Groups ◽  
Sexual Risk Taking ◽  
Syphilis Infection ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Crucial Component ◽  
Sex With Men

Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections are common among men who have sex with men (MSM). Many oropharyngeal and anorectal infections remain asymptomatic. We aimed to evaluate triple-site screening following PrEP introduction. We enrolled a prospective cohort study including 210 asymptomatic MSM during 2019–2020, analyzed by groups: HIV positive (HIV+), HIV−uninfected using PrEP (HIV−/PrEP+), or HIV-uninfected not using PrEP (HIV−/PrEP−). A self-administered questionnaire captured demographic information and sexual risk-taking behaviors. CT/NG testing results were compared between study groups and predictors of infection were evaluated. We included 59 HIV+, 70 HIV−/PrEP+, and 81 HIV−/PrEP− subjects. 30% ( n = 62) of participants tested positive for CT/NG. HIV−/PrEP+ group had highest proportion of infections ( n = 33, 47%) followed by HIV−/PrEP− ( n = 16, 22%) and HIV+ ( n=13, 20%; p < .001). Importantly, 98% (80/82) of pharyngeal/anorectal CT/NG infections were missed in genitourinary tract screening alone. PrEP use and previous syphilis infection were the strongest risk factor for CT/NG. Extra-genital asymptomatic CT/NG infections were prevalent among MSM. These data highlight the importance of routine extra-genital CT/NG testing in asymptomatic sexually active MSM. The study describes the consequences for three-site testing lack of implementation in the PrEP era.

Performance of SLE responder index and lupus low disease activity state in real life: A prospective cohort study

2019 ◽  
Vol 22 (9) ◽  
pp. 1752-1761 ◽  
Author(s):  
Giuseppe A. Ramirez ◽  
Valentina Canti ◽  
Lucia Moiola ◽  
Marco Magnoni ◽  
Patrizia Rovere‐Querini ◽  
...  
Keyword(s):  
Cohort Study ◽  
Disease Activity ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Real Life ◽  
Low Disease Activity ◽  
Activity State

Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study

AIDS ◽  
2011 ◽  
Vol 25 (4) ◽  
pp. 493-501 ◽  
Author(s):  
Irálice AV Jansen ◽  
Ronald B Geskus ◽  
Udi Davidovich ◽  
Suzanne Jurriaans ◽  
Roel A Coutinho ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Sex With Men ◽  
Hiv 1
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