scholarly journals Realizing the potential of routine viral load testing in sub-Saharan Africa

2017 ◽  
Vol 20 ◽  
pp. e25010 ◽  
Author(s):  
Wafaa M El-Sadr ◽  
Miriam Rabkin ◽  
John Nkengasong ◽  
Deborah L Birx
Keyword(s):  
Viral Load ◽  
Sub Saharan Africa ◽  
Load Testing ◽  
Viral Load Testing ◽  
Sub Saharan

scholarly journals Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile

2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Andrew N. Phillips ◽  
Valentina Cambiano ◽  
Fumiyo Nakagawa ◽  
Deborah Ford ◽  
Tsitsi Apollo ◽  
...  
Keyword(s):  
Viral Load ◽  
Point Of Care ◽  
Sub Saharan Africa ◽  
Load Testing ◽  
Viral Load Testing ◽  
Trade Offs ◽  
Art Program ◽  
Product Profile ◽  
Load Tests ◽  
Sub Saharan

Abstract Point-of-care viral load tests are being developed to monitor patients on antiretroviral therapy (ART) in sub-Saharan Africa. Test design involves trade-offs between test attributes, including accuracy, complexity, robustness, and cost. We used a model of the human immunodeficiency virus epidemic and ART program in Zimbabwe and found that the attributes of a viral load testing approach that are most influential for cost effectiveness are avoidance of a high proportion of failed tests or results not received, use of an approach that best facilitates retention on ART, and the ability to facilitate greater use of differentiated care, including through expanding coverage of testing availability.

scholarly journals How do different eligibility guidelines for antiretroviral therapy affect the cost–effectiveness of routine viral load testing in sub-Saharan Africa?

AIDS ◽  
2014 ◽  
Vol 28 ◽  
pp. S73-S83 ◽  
Author(s):  
Ronald Scott Braithwaite ◽  
Kimberly A. Nucifora ◽  
Christopher Toohey ◽  
Jason Kessler ◽  
Lauren M. Uhler ◽  
...  
Keyword(s):  
Viral Load ◽  
Cost Effectiveness ◽  
Antiretroviral Therapy ◽  
Sub Saharan Africa ◽  
Load Testing ◽  
Viral Load Testing ◽  
Sub Saharan ◽  
The Cost

scholarly journals Determining virological suppression and resuppression by point-of-care viral load testing in a HIV care setting in sub-Saharan Africa

2020 ◽  
Vol 18 ◽  
pp. 100231
Author(s):  
Giovanni Villa ◽  
Adam Abdullahi ◽  
Dorcas Owusu ◽  
Colette Smith ◽  
Marilyn Azumah ◽  
...  
Keyword(s):  
Viral Load ◽  
Care Setting ◽  
Point Of Care ◽  
Virological Suppression ◽  
Sub Saharan Africa ◽  
Hiv Care ◽  
Load Testing ◽  
Viral Load Testing ◽  
Sub Saharan

scholarly journals Development and validation of systems for rational use of viral load testing in adults receiving first-line ART in sub-Saharan Africa

AIDS ◽  
2011 ◽  
Vol 25 (13) ◽  
pp. 1627-1635 ◽  
Author(s):  
Michael Abouyannis ◽  
Joris Menten ◽  
Agnes Kiragga ◽  
Lutgarde Lynen ◽  
Gavin Robertson ◽  
...  
Keyword(s):  
Viral Load ◽  
Sub Saharan Africa ◽  
Load Testing ◽  
First Line ◽  
Rational Use ◽  
Viral Load Testing ◽  
Sub Saharan ◽  
Development And Validation

scholarly journals Viral load care of HIV-1 infected children and adolescents: A longitudinal study in rural Zimbabwe

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245085
Author(s):  
Tichaona Mapangisana ◽  
Rhoderick Machekano ◽  
Vinie Kouamou ◽  
Caroline Maposhere ◽  
Kathy McCarty ◽  
...  
Keyword(s):  
Viral Load ◽  
Children And Adolescents ◽  
Virologic Failure ◽  
Sub Saharan Africa ◽  
Virologic Suppression ◽  
Second Line ◽  
Load Testing ◽  
Viral Load Suppression ◽  
Viral Load Testing

Introduction Maintaining virologic suppression of children and adolescents on ART in rural communities in sub-Saharan Africa is challenging. We explored switching drug regimens to protease inhibitor (PI) based treatment and reducing nevirapine and zidovudine use in a differentiated community service delivery model in rural Zimbabwe. Methods From 2016 through 2018, we followed 306 children and adolescents on ART in Hurungwe, Zimbabwe at Chidamoyo Christian Hospital, which provides compact ART regimens at 8 dispersed rural community outreach sites. Viral load testing was performed (2016) by Roche and at follow-up (2018) by a point of care viral load assay. Virologic failure was defined as viral load ≥1,000 copies/ml. A logistic regression model which included demographics, treatment regimens and caregiver’s characteristics was used to assess risks for virologic failure and loss to follow-up (LTFU). Results At baseline in 2016, 296 of 306 children and adolescents (97%) were on first-line ART, and only 10 were receiving a PI-based regimen. The median age was 12 years (IQR 8–15) and 55% were female. Two hundred and nine (68%) had viral load suppression (<1,000 copies/ml) and 97(32%) were unsuppressed (viral load ≥1000). At follow-up in 2018, 42/306 (14%) were either transferred 23 (7%) or LTFU 17 (6%) and 2 had died. In 2018, of the 264 retained in care, 107/264 (41%), had been switched to second-line, ritonavir-boosted PI with abacavir as a new nucleotide analog reverse transcriptase inhibitor (NRTI). Overall viral load suppression increased from 68% in 2016 to 81% in 2018 (P<0.001). Conclusion Viral load testing, and switching to second-line, ritonavir-boosted PI with abacavir significantly increased virologic suppression among HIV-infected children and adolescents in rural Zimbabwe.

scholarly journals Viral Load Testing for HIVBeyond the CD4 Count

1999 ◽  
Vol 30 (2) ◽  
pp. 102-108
Author(s):  
Patricia Bereck Weikersheimer
Keyword(s):  
Viral Load ◽  
Cd4 Count ◽  
Load Testing ◽  
Viral Load Testing
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