New 7-substituted quinolone antibacterial agents. The synthesis of 1-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl and 4-thiazolyl)-3-quinolinecarboxylic acids

1987 ◽  
Vol 24 (6) ◽  
pp. 1509-1520 ◽  
Author(s):  
Townley P. Culbertson ◽  
John M. Domagala ◽  
Phred Peterson ◽  
Shannon Bongers ◽  
Jeffrey B. Nichols
Keyword(s):  
Antibacterial Agents ◽  
Quinolinecarboxylic Acids

Synthesis of benzimidazo-substituted 3-quinolinecarboxylic acids as antibacterial agents

1990 ◽  
Vol 27 (5) ◽  
pp. 1177-1180 ◽  
Author(s):  
Miguel F. Bran̂a ◽  
José M. Castellano ◽  
María J. R. Yunta
Keyword(s):  
Antibacterial Agents ◽  
Quinolinecarboxylic Acids

ChemInform Abstract: Synthesis of Benzimidazo-Substituted 3-Quinolinecarboxylic Acids as Antibacterial Agents.

ChemInform ◽  
2010 ◽  
Vol 22 (1) ◽  
pp. no-no
Author(s):  
M. F. BRANA ◽  
J. M. CASTELLANO ◽  
M. J. R. YUNTA
Keyword(s):  
Antibacterial Agents ◽  
Quinolinecarboxylic Acids

Dermatitis in pets: Study of Brazilian savannah plants as potential antibacterial agents

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
AC Valle ◽  
L Rabelo ◽  
AL Magalhães ◽  
M Neves ◽  
I Maciel ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Brazilian Savannah

Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening

2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Energy Coupling ◽  
Coupling Factor ◽  
Design Synthesis ◽  
Screening Design ◽  
Starting Point ◽  
Wide Range ◽  
Vitamin Uptake

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>

RESULTS OF ENDODONTIC APPLICATION OF VARIOUS ANTIBACTERIAL AGENTS AND CLINICAL AND MICROBIOLOGICAL FEATURES

2019 ◽  
pp. 51-53
Author(s):  
D. S. Tulanov ◽  
S. K. Dalimova ◽  
N. I. Juraeva ◽  
S. R. Mamarasulova
Keyword(s):  
Antibacterial Agents
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