Pyrrolopyridazines. II. Synthesis of the novel pyrrolo[3,2-c]pyridazine ring system

1973 ◽  
Vol 10 (5) ◽  
pp. 807-812 ◽  
Author(s):  
P. Dan Cook ◽  
Raymond N. Castle
Keyword(s):  
Ring System ◽  
The Novel ◽  
Pyridazine Ring

scholarly journals Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3268
Author(s):  
Katja S. Håheim ◽  
Emil Lindbäck ◽  
Kah Ni Tan ◽  
Marte Albrigtsen ◽  
Ida T. Urdal Helgeland ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antimicrobial Activities ◽  
Ring System ◽  
Human Prostate ◽  
The Novel ◽  
Human Prostate Cancer ◽  
Biofilm Inhibition

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine 4b to be significantly more active against human prostate cancer (IC50 = 24 nM) than Puromycin (IC50 = 270 nM) and Doxorubicin (IC50 = 830 nM), which are used for clinical treatment. Pyridocarbazoles 9 was also moderately effective against all the employed cancer cell lines and moreover showed excellent biofilm inhibition (9a: MBIC = 100 µM; 9b: MBIC = 100 µM).

Iminophosphorane-mediated synthesis of fused [1,2,4]triazines: preparation of the novel [1,2,4]triazino[4,3-b][1,2,4,5]tetrazine ring system

Tetrahedron ◽  
1988 ◽  
Vol 44 (8) ◽  
pp. 2249-2259 ◽  
Author(s):  
Pedro Molina ◽  
Mateo Alajarin ◽  
Angel Vidal ◽  
J. Elguero ◽  
R.M. Claramunt
Keyword(s):  
Ring System ◽  
The Novel

scholarly journals NMR and X-ray Studies Concerning Structure of 6,6’-(Oxybis(4,1-phenylene))bis-(2-allylpyridazin- 3(2H)-one)

2014 ◽  
Vol 22 (1) ◽  
pp. 25-38 ◽  
Author(s):  
Vasilichia Antoci ◽  
Mircea Apostu ◽  
Catalina Ciobanu ◽  
Dorina Mantu
Keyword(s):  
Phenyl Ring ◽  
Room Temperature ◽  
Heterocyclic System ◽  
Crystal Packing ◽  
Diphenyl Ether ◽  
The Novel ◽  
X Ray ◽  
Pyridazine Ring ◽  
Phenyl Rings ◽  
C Nmr

Abstract The structural NMR and X-ray studies of 6,6’-(Oxybis(4,1- phenylene))bis-(2-allylpyridazin-3(2H)-one), a bis-pyridazine derivative heterocycle, are reported in this study. Both 1H- and 13C- NMR confirm the proposed structure of compound. In order to establish unequivocally the structure of compound, the X-ray data analysis was performed. The compound crystallizes in the triclinic P-1(2) space group with a = 10.3699(7) Å, b = 10.6972(6) Å, c = 11.0449(4) Å, α = 87.941(5)°, β = 75.564(5)°, γ = 72.055(5)°, V= 1127.68 (12) Å3 and Z = 2. Molecular and crystal packing parameters for the novel heterocyclic system were obtained from intensity data collected at room temperature. The two phenyl rings (from the diphenyl ether moiety) are perpendicular one to each other and, on its turn, each phenyl ring is almost coplanar with the pyridazine ring

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