Groebke‐Blackburn‐Bienaymé Multicomponent Reaction Coupled with Unconventional Pictet‐Spengler Cyclization for the Synthesis of Imidazo[4,5‐ b ]pyridine Fused Polycyclic Heterocycles

2021 ◽  
Author(s):  
Rahul Singh ◽  
Ravinder Kumar ◽  
Manpreet Kaur ◽  
Madhuri T. Patil ◽  
Subash Chandra Sahoo ◽  
...  
Keyword(s):  
Multicomponent Reaction

scholarly journals Electrochemical multicomponent synthesis of 4-selanylpyrazoles under catalyst- and chemical-oxidant-free conditions

2021 ◽  
Author(s):  
Yan Wu ◽  
Jin-Yang Chen ◽  
Jing Ning ◽  
Xue Jiang ◽  
Jie Deng ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Raw Materials ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Simple Protocol ◽  
High Yields

An electrochemical multicomponent reaction was established under catalyst-, chemical-oxidant-free and mild conditions, which provides an eco-friendly and simple protocol for constructing 4-selanylpyrazoles from easily available raw materials with high yields.

ChemInform Abstract: Multicomponent Reaction for Synthesis of 2-(Indol-3-yl)pyridine Derivatives under Microwave Irradiation.

ChemInform ◽  
2012 ◽  
Vol 43 (18) ◽  
pp. no-no
Author(s):  
Li-Jun Geng ◽  
Guo-Liang Feng ◽  
Jiu-Gao Yu ◽  
Hong-Li Zhang ◽  
Yu-Mei Zhang
Keyword(s):  
Microwave Irradiation ◽  
Multicomponent Reaction ◽  
Pyridine Derivatives

Prediction of multicomponent reaction yields using machine learning

2021 ◽  
Author(s):  
Xing‐Yong Zhu ◽  
Chuan‐Kun Ran ◽  
Ming Wen ◽  
Gui‐Ling Guo ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Multicomponent Reaction

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

Tandem Alkylation/Michael Addition Reaction of Dithiocarbamic Acids with Alkyl γ-Bromocrotonates: Access to Functionalized 1,3-Thiazolidine-2-thiones

Synthesis ◽  
2021 ◽  
Author(s):  
Azim Ziyaei Halimehjani ◽  
Petr Beier ◽  
Maryam Khalili Foumeshi ◽  
Ali Alaei ◽  
Blanka Klepetářová
Keyword(s):  
Amino Acids ◽  
Carbon Disulfide ◽  
Multicomponent Reaction ◽  
Michael Addition ◽  
Addition Reaction ◽  
Primary Amines ◽  
Oxidation Reactions ◽  
Michael Addition Reaction ◽  
Synthetic Utility ◽  
Reaction Proceeds

AbstractThiazolidine-2-thiones were prepared via a novel multicomponent reaction of primary amines (amino acids), carbon disulfide, and γ-bromocrotonates. The reaction proceeds via a domino alkylation/intramolecular Michael addition to provide the corresponding thiazolidine-2-thiones in high to excellent yields. By using diamines in this protocol, bis(thiazolidine-2-thiones) derivatives were synthesized. The synthetic utility of the adducts was demonstrated by hydrolysis, amidation, and oxidation reactions.

scholarly journals The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 558
Author(s):  
Marta Serafini ◽  
Ilaria Murgia ◽  
Mariateresa Giustiniano ◽  
Tracey Pirali ◽  
Gian Cesare Tron
Keyword(s):  
Organic Chemistry ◽  
Knowledge Sharing ◽  
Multicomponent Reaction ◽  
Review Article ◽  
Chronological Order ◽  
New Applications

Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929–1966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharing will help chemists to properly use this multicomponent transformation and imagine novel reactivities based on it.

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