Heterocyclic compounds as antiviral drugs: synthesis, structure‐activity relationship and traditional applications

2021 ◽  
Author(s):  
Giovanny Carvalho dos Santos ◽  
Lucas Michelão Martins ◽  
Bruna Andressa Bregadiolli ◽  
Vitor Fernandes Moreno ◽  
Luiz Carlos da Silva‐Filho ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Structure Activity Relationship ◽  
Antiviral Drugs ◽  
Activity Relationship ◽  
Structure Activity

scholarly journals Styrylchromones: Biological Activities and Structure-Activity Relationship

2021 ◽  
Vol 2021 ◽  
pp. 1-47
Author(s):  
Mariana Lucas ◽  
Marisa Freitas ◽  
Artur M. S. Silva ◽  
Eduarda Fernandes ◽  
Daniela Ribeiro
Keyword(s):  
Adenosine Receptors ◽  
Heterocyclic Compounds ◽  
Literature Search ◽  
Biological Activities ◽  
Structure Activity Relationship ◽  
New Drugs ◽  
Activity Relationship ◽  
Comprehensive Review ◽  
Structure Activity ◽  
Styryl Group

Styrylchromones (SC) are a group of oxygen-containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2-styrylchromones and 3-styrylchromones. However, 2-styrylchromones are the most common, being more commonly found in nature and which chemical synthesis is more commonly described. A wide variety of SC has been described in the literature, with different substituents in different positions, the majority of which are distributed on the A- and/or B-rings. Over the years, several biological activities have been attributed to SC. This work presents a comprehensive review of the biological activities attributed to SC and their structure-activity relationship, based on a published literature search, since 1989. The following biological activities are thoroughly revised and discussed in this review: antioxidant, antiallergic, antiviral, antibacterial, antifungal, anti-inflammatory, and antitumoral, affinity and selectivity for A3 adenosine receptors, neuroprotective, and α-glucosidase inhibition. In general, SC are composed by a promising scaffold with great potential for the development of new drugs.

scholarly journals A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

2022 ◽  
Vol 2022 ◽  
pp. 1-50
Author(s):  
Mahrokh Marzi ◽  
Mojtaba Farjam ◽  
Zahra Kazeminejad ◽  
Abolfazl Shiroudi ◽  
Amin Kouhpayeh ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Heterocyclic Compounds ◽  
Antifungal Agents ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Synthesis Mechanism ◽  
Structure Activity ◽  
Antifungal Effects ◽  
Recent Developments ◽  
Membered Heterocycle

A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibacterial, anti-inflammatory, anticancer, antioxidant, antiviral, and antidiabetic properties. This heterocycle molecule, in particular, with one or more 1,2,3-triazole cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure-activity relationship (SAR) investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. This review will be useful in a variety of fields, including medicinal chemistry, organic chemistry, mycology, and pharmacology.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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