Design, synthesis, and bioactivity evaluation of novel thiochromanone derivatives containing an oxime or oxime ether moiety

2021 ◽  
Author(s):  
Lu Yu ◽  
Lingling Xiao ◽  
Jiyan Chi ◽  
Zhangfei Tang ◽  
Jie Li ◽  
...  
Keyword(s):  
Oxime Ether ◽  
Design Synthesis

scholarly journals Design, Synthesis, Molecular Docking and Biological Evaluation of Novel Coumarin-Oxime Ether Derivatives as COX-2 Inhibitors

2017 ◽  
Vol 29 (11) ◽  
pp. 2559-2564
Author(s):  
M. Vijaya Bhargavi ◽  
P. Shashikala ◽  
M. Sumakanth ◽  
Shravan Kumar Gunda
Keyword(s):  
Molecular Docking ◽  
Biological Evaluation ◽  
Oxime Ether ◽  
Design Synthesis ◽  
Cox 2 ◽  
Cox 2 Inhibitors

scholarly journals Design, Synthesis and Fungicidal Activity of New 1,2,4-Triazole Derivatives Containing Oxime Ether and Phenoxyl Pyridinyl Moiety

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5852
Author(s):  
Hui Bai ◽  
Xuelian Liu ◽  
Pengfei Chenzhang ◽  
Yumei Xiao ◽  
Bin Fu ◽  
...  
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Binding Modes ◽  
Oxime Ether ◽  
Single Crystal Diffraction ◽  
Design Synthesis ◽  
Antifungal Activities ◽  
Triazole Derivatives ◽  
Pyridine Moiety ◽  
New Compounds

A series of novel 1,2,4-triazole derivatives containing oxime ether and phenoxy pyridine moiety were designed and synthesized. The new compounds were identified by nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). Compound (Z)-1-(6-(4-nitrophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a18) was further confirmed by X-ray single crystal diffraction. Their antifungal activities were evaluated against eight phytopathogens. The in vitro bioassays indicated that most of the title compounds displayed moderate to high fungicidal activities. Compound (Z)-1-(6-(4-bromo-2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a4) exhibited a broad-spectrum antifungal activities with the EC50 values of 1.59, 0.46, 0.27 and 11.39 mg/L against S. sclerotiorum, P. infestans, R. solani and B. cinerea, respectively. Compound (Z)-1-(6-(2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-benzyl oxime (5b2) provided the lowest EC50 value of 0.12 mg/L against S. sclerotiorum, which were comparable to the commercialized difenoconazole. Moreover, homologous modeling and molecular docking disclosed possible binding modes of compounds 5a4 and 5b2 with CYP51. This work provided useful guidance for the discovery of new 1,2,4-triazole fungicides.

Design, Synthesis, Acaricidal Activity, and Mechanism of Oxazoline Derivatives Containing an Oxime Ether Moiety

2014 ◽  
Vol 62 (14) ◽  
pp. 3064-3072 ◽  
Author(s):  
Yongqiang Li ◽  
Chaojie Li ◽  
Yanlong Zheng ◽  
Xingcun Wei ◽  
Qiaoqiao Ma ◽  
...  
Keyword(s):  
Acaricidal Activity ◽  
Oxime Ether ◽  
Design Synthesis ◽  
Oxazoline Derivatives

Design, Synthesis, and Biological Activity of Oxime Ether Strobilurin Derivatives Containing Indole Moiety as Novel Fungicide

2014 ◽  
Vol 85 (6) ◽  
pp. 743-755 ◽  
Author(s):  
Ya-Qiang Xie ◽  
Zi-Long Huang ◽  
Hui-Dong Yan ◽  
Jun Li ◽  
Li-Yi Ye ◽  
...  
Keyword(s):  
Biological Activity ◽  
Oxime Ether ◽  
Design Synthesis

Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity

2008 ◽  
Vol 18 (24) ◽  
pp. 6386-6389 ◽  
Author(s):  
Yong-Mei Cui ◽  
Eriko Yasutomi ◽  
Yuko Otani ◽  
Takashi Yoshinaga ◽  
Katsutoshi Ido ◽  
...  
Keyword(s):  
Bk Channel ◽  
Oxime Ether ◽  
Design Synthesis ◽  
Channel Opening ◽  
Derivatives Of

Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives

2006 ◽  
Vol 16 (3) ◽  
pp. 569-572 ◽  
Author(s):  
Ghilsoo Nam ◽  
Tae Won Kang ◽  
Jung Hyu Shin ◽  
Kyung Il Choi
Keyword(s):  
Helicobacter Pylori ◽  
Oxime Ether ◽  
Design Synthesis ◽  
Erythromycin A

Design, synthesis and biological activities of novel 1,2,3-thiadiazole derivatives containing oxime ether

2008 ◽  
Vol 2008 (3) ◽  
pp. 145-147 ◽  
Author(s):  
Wei-Li Dong ◽  
Hong-Wei Yao ◽  
Zheng-Ming Li ◽  
Wei-Guang Zhao
Keyword(s):  
Biological Activities ◽  
Oxime Ether ◽  
Design Synthesis ◽  
Thiadiazole Derivatives

Design, Synthesis, and Fungicidal Activities of Novel Piperidyl Thiazole Derivatives Containing Oxime Ether or Oxime Ester Moieties

2021 ◽  
Vol 69 (13) ◽  
pp. 3848-3858
Author(s):  
Qiang Bian ◽  
Rui-Qi Zhao ◽  
Xing-Jie Peng ◽  
Li-Jie Gao ◽  
Guo-Na Zhou ◽  
...  
Keyword(s):  
Oxime Ether ◽  
Thiazole Derivatives ◽  
Design Synthesis

Novel penta-1,4-diene-3-one derivatives containing quinazoline and oxime ether fragments: Design, synthesis and bioactivity

2021 ◽  
pp. 115999
Author(s):  
Shijun Su ◽  
Mei Chen ◽  
Qin Li ◽  
Yihui Wang ◽  
Shuai Chen ◽  
...  
Keyword(s):  
Oxime Ether ◽  
Design Synthesis
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