Synthesis and antitumor activity of some nitrogen heterocycles bearing pyrimidine moiety

2020 ◽  
Author(s):  
Marwa H. Ahmed ◽  
Maher A. El‐Hashash ◽  
Magda I. Marzouk ◽  
Abeer M. El‐Naggar
Keyword(s):  
Antitumor Activity ◽  
Nitrogen Heterocycles ◽  
Pyrimidine Moiety

Synthesis, characterization and antitumor activity of novel ferrocene bisamide derivatives containing pyrimidine-moiety

2017 ◽  
Vol 851 ◽  
pp. 150-159 ◽  
Author(s):  
Ying Guo ◽  
Si-Qi Wang ◽  
Zong-Qing Ding ◽  
Jia Zhou ◽  
Ban-Feng Ruan
Keyword(s):  
Antitumor Activity ◽  
Pyrimidine Moiety

ChemInform Abstract: INVESTIGATION OF THE ANTITUMOR ACTIVITY OF NEW EPOXIDE DERIVATIVES. PART II: N-GLYCIDYLATED OXO-NITROGEN HETEROCYCLES

1984 ◽  
Vol 15 (43) ◽  
Author(s):  
H. FISCHER ◽  
H. MOELLER ◽  
M. BUDNOWSKI ◽  
G. ATASSI ◽  
P. DUMONT ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Nitrogen Heterocycles

Radioprotective and Antitumor Activity of Some Novel Amino Acids and Imidazoles Containing Thieno[2,3-d]pyrimidine Moiety

2009 ◽  
Vol 184 (12) ◽  
pp. 3241-3257 ◽  
Author(s):  
Saleh I. Alqasoumi ◽  
Fatma A. Ragab ◽  
Ahmed M. Alafeefy ◽  
Marwa Galal ◽  
Mostafa M. Ghorab
Keyword(s):  
Amino Acids ◽  
Antitumor Activity ◽  
Pyrimidine Moiety

Synthesis of some nitrogen heterocycles and in vitro evaluation of their antimicrobial and antitumor activity

2013 ◽  
Vol 40 (2) ◽  
pp. 537-553 ◽  
Author(s):  
J. A. Hasanen ◽  
I. M. El-Deen ◽  
R. M. El-Desoky ◽  
A. M. Abdalla
Keyword(s):  
Antitumor Activity ◽  
Nitrogen Heterocycles ◽  
In Vitro Evaluation

Hydrogen Cyanide Polymers from the Impact of Comet P/Shoemaker-Levy 9 on Jupiter

1997 ◽  
Vol 161 ◽  
pp. 179-187
Author(s):  
Clifford N. Matthews ◽  
Rose A. Pesce-Rodriguez ◽  
Shirley A. Liebman
Keyword(s):  
Amino Acids ◽  
Solar System ◽  
Hydrogen Cyanide ◽  
Nitrogen Heterocycles ◽  
Laboratory Studies ◽  
Heterogeneous Solids ◽  
The Many ◽  
Comet Halley ◽  
The Impact ◽  
By Products

AbstractHydrogen cyanide polymers – heterogeneous solids ranging in color from yellow to orange to brown to black – may be among the organic macromolecules most readily formed within the Solar System. The non-volatile black crust of comet Halley, for example, as well as the extensive orangebrown streaks in the atmosphere of Jupiter, might consist largely of such polymers synthesized from HCN formed by photolysis of methane and ammonia, the color observed depending on the concentration of HCN involved. Laboratory studies of these ubiquitous compounds point to the presence of polyamidine structures synthesized directly from hydrogen cyanide. These would be converted by water to polypeptides which can be further hydrolyzed to α-amino acids. Black polymers and multimers with conjugated ladder structures derived from HCN could also be formed and might well be the source of the many nitrogen heterocycles, adenine included, observed after pyrolysis. The dark brown color arising from the impacts of comet P/Shoemaker-Levy 9 on Jupiter might therefore be mainly caused by the presence of HCN polymers, whether originally present, deposited by the impactor or synthesized directly from HCN. Spectroscopic detection of these predicted macromolecules and their hydrolytic and pyrolytic by-products would strengthen significantly the hypothesis that cyanide polymerization is a preferred pathway for prebiotic and extraterrestrial chemistry.

710: TNF-Related Apoptosis Inducing Ligand (TRAIL/APO-2L): A Novel Mechanism for BCG-Induced Antitumor Activity

2004 ◽  
Vol 171 (4S) ◽  
pp. 188-189
Author(s):  
Aaron T. Ludwig ◽  
Jill M. Moore ◽  
Yi Luo ◽  
Xiaohong Chen ◽  
Michael A. O’Donnell ◽  
...  
Keyword(s):  
Antitumor Activity
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