Synthesis of 1,2,4,5‐tetrasubstituted imidazoles and 2,4,5,6‐tetrasubstituted pyrimidines: three‐component, the one‐pot reaction of arylamidines, malononitrile, and arylglyoxals or aryl aldehydes

2020 ◽  
Author(s):  
Hossein Mehrabi ◽  
Mina Hajipour ◽  
Fatemeh Rezazadeh‐Jabalbarezi ◽  
Farzaneh Alizadeh‐Bami
Keyword(s):  
One Pot ◽  
Aryl Aldehydes ◽  
The One ◽  
Tetrasubstituted Imidazoles

Glutamic Acid as an Efficient and Green Catalyst for the One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles under Thermal, Solvent-Free Conditions

2017 ◽  
Vol 41 (11) ◽  
pp. 673-675 ◽  
Author(s):  
Fahimeh Khazaee Feizabad ◽  
Khatereh Khandan-Barani ◽  
Alireza Hassanabadi
Keyword(s):  
Glutamic Acid ◽  
Reaction Times ◽  
Catalytic Amount ◽  
Solvent Free ◽  
One Pot ◽  
Green Catalyst ◽  
Aryl Aldehydes ◽  
Solvent Free Conditions ◽  
The One ◽  
Tetrasubstituted Imidazoles

A high-yielding synthesis of 1,2,4,5-tetrasubstituted imidazoles is described, involving the reaction of 1,2-dicarbonyl compounds, aryl aldehydes, amines and ammonium acetate in the presence of a catalytic amount of glutamic acid under thermal, solvent-free conditions. The salient features of this protocol are aerobic conditions, a non-hazardous green catalyst, short reaction times and mild reaction conditions.

A new more atom-efficient multi-component approach to tetrasubstituted imidazoles: one-pot condensation of nitriles, amines and benzoin

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 67281-67289 ◽  
Author(s):  
Ali Khalafi-Nezhad ◽  
Mohsen Shekouhy ◽  
Hashem Sharghi ◽  
Jasem Aboonajmi ◽  
Abdolkarim Zare
Keyword(s):  
Primary Amines ◽  
One Pot ◽  
One Pot Condensation ◽  
Component Approach ◽  
The One ◽  
Tetrasubstituted Imidazoles

A new more atom-efficient multi-component approach for the synthesis of tetrasubstituted imidazoles via the one-pot condensation of nitriles, primary amines and benzoin has been described.

PTSA-Catalyzed One Pot Domino Synthesis of Dihydropyrido[2,3-d]pyrimidine Derivatives and their Antimicrobial Activity

2021 ◽  
Vol 6 (3) ◽  
pp. 222-227
Author(s):  
Krishna A. Bhensdadia ◽  
Prakash L. Kalavadiya ◽  
Nilam H. Lalavani ◽  
Shipra H. Baluja
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
In Vitro Antimicrobial Activity ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
The One

A novel series of dihydropyrido[2,3-d]pyrimidine derivatives were synthesized by multicomponent domino cyclization via the one-pot three component reaction of 6-amino uracil, substituted aryl aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine in the presence of PTSA 10 mol% as a catalyst. The structures of these synthesized compounds were characterized by spectral analysis. Further the synthesized compounds screened for in vitro antimicrobial activity. Among all the compounds, compound 4b containing flouro substitution exhibited good inhibition against the tested species.

BF3·SiO2: an efficient reagent system for the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles

2008 ◽  
Vol 49 (16) ◽  
pp. 2575-2577 ◽  
Author(s):  
Bahareh Sadeghi ◽  
Bi Bi Fatemeh Mirjalili ◽  
Mohammad M. Hashemi
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Tetrasubstituted Imidazoles ◽  
Efficient Reagent

scholarly journals H4SiW12O40Catalyzed One-Pot Synthesis of 12-Aryl-8,9,10,12-tetrahydrobenzo[a] Xanthen-11-ones Under Solvent-Free Conditions

2012 ◽  
Vol 9 (2) ◽  
pp. 786-790 ◽  
Author(s):  
A. Hassankhani ◽  
E. Mosaddegh ◽  
S. Y. Ebrahimipour
Keyword(s):  
Catalytic Activity ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Reusable Catalyst ◽  
High Catalytic Activity ◽  
One Pot ◽  
Aryl Aldehydes ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
The One

An efficient and environmentally benign protocol for the one-pot, three-component synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-one derivatives by condensation of aryl aldehydes, 2-naphthol and dimedone using H4SiW12O40(SiWA) as a reusable catalyst with high catalytic activity was reported. The reaction was carried out at 100 ºC under solvent-free conditions within 15-40 min in 82-91% yield.

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