An Eco‐friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene Moiety via Gewald Reaction

2019 ◽  
Vol 56 (10) ◽  
pp. 2787-2795 ◽  
Author(s):  
Mohamed A. El‐Borai ◽  
Hala F. Rizk ◽  
Seham A. Ibrahim ◽  
Amira K. Fares
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Screening ◽  
Gewald Reaction ◽  
Thiophene Moiety

scholarly journals Synthesis of Chlorinated 3,5 Diaryl 2 Pyrazrolines

2021 ◽  
pp. 476-479
Author(s):  
Pratiksha S. Rathod ◽  
Shilpa G. Chavan
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Heterocyclic Compounds ◽  
Mass Spectra ◽  
Biological Activities ◽  
Research Activity ◽  
Biological Screening ◽  
Pharmaceutical Applications

Pyrazolines are important nitrogen containing 5-membered heterocyclic compounds. Various, pyrazoline derivatives have been found to possess considerable biological and pharmaceutical applications as activities, which stimulated the research activity in this field. The chlorinated 3,5-diary-l-2-pyrazolines has been synthesized by reaction of appropriately substituted chloro chalcones and mono-substituted hydrazine’s have been synthesized. These compounds were characterized using IR, 1H-NMR and Mass spectra and Elemental analysis. They possess some potent biological activities. Therefore, biological screening of novel compounds has been also done.

scholarly journals Synthesis and biological screening of some novel pyrazolo[3’,4’:4,5]thieno[2,3-d]pyrimidin-8-ones via Gewald reaction

ARKIVOC ◽  
2008 ◽  
Vol 2008 (12) ◽  
pp. 1-8 ◽  
Author(s):  
Shailesh J. Vaghasiya ◽  
Dipti K. Dodiya ◽  
Amit R. Trivedi ◽  
Janak J. Surani ◽  
Viresh H. Shah
Keyword(s):  
Biological Screening ◽  
Gewald Reaction

scholarly journals Preparation and Biological Screening of Novel Heterocyclic Compounds

2019 ◽  
Vol Volume-3 (Issue-3) ◽  
pp. 632-636
Author(s):  
Pranay Shah ◽  
R. I. Patel ◽  
P. J. Vyas ◽  
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Screening

Probing the Carbon-Nitrogen Bonding in Heterocyclic Compounds with the N K-Shell Excitation Spectroscopy

1997 ◽  
Vol 7 (C2) ◽  
pp. C2-527-C2-528
Author(s):  
St Bender ◽  
R. Franke ◽  
J. Hormes ◽  
A. A. Pavlychev ◽  
N. G. Fominykh ◽  
...  
Keyword(s):  
Heterocyclic Compounds

Antiviral Activity of Fluorinated Heterocyclic Compounds

2016 ◽  
Author(s):  
Liubov Biliavska ◽  
Yulia Pankivska ◽  
Olga Povnitsa ◽  
Svitlana Zagorodnya ◽  
Ganna Gudz ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Heterocyclic Compounds ◽  
Strong Antiviral Activity

Synthesis and Characterization of Some New Esters Containing Heterocyclic and Derived From Azo Dyes

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Zena G. Alrecabi ◽  
Zainab Amer ◽  
Naeemah Al-Lami
Keyword(s):  
Schiff Base ◽  
13C Nmr ◽  
Azo Dyes ◽  
Spectral Methods ◽  
Anthranilic Acid ◽  
Heterocyclic Compounds ◽  
Synthesis And Characterization ◽  
Cooh Group ◽  
Molecular Weights

This study including prepared new colored esters containing heterocyclic with high molecular weights. In the first part of work we synthesized azo dyes [1,2] from the reaction p-toluidine with β-naphthol and o-nitro phenol, thin we synthesized Schiff bases [3,4] by the reaction anthranilic acid with benzaldehyde and dimethyl benzaldehyde. The reaction azo dyes (contain OH group) with Schiff base (contain COOH group) these led to produce the new colored esters [A1-A4]. The second part of work was modification the (C=N-) group in esters to heterocyclic compounds by reacting with phenyl iso cyanide to produce new β-lactam [B1-B4] and with anthranilic acid to get new hydroquinazoline [C1-C4]. All these compounds were characterized by physical properties and spectral methods FTIR, 1H-NMR and 13C-NMR.

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

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