Synthesis of Novel Alkyl Amide Functionalized Trifluoromethyl Substituted Furo/thieno Pyridine Derivatives: Their Anticancer Activity and CoMFA and CoMSIA Studies

2019 ◽  
Vol 56 (7) ◽  
pp. 1986-1998 ◽  
Author(s):  
Srinu Bhoomandla ◽  
Shravan Kumar Gunda ◽  
Srawanthi Kotoori ◽  
Phani Raja Kanuparthy
Keyword(s):  
Anticancer Activity ◽  
Pyridine Derivatives ◽  
Alkyl Amide

In silico studies, synthesis and anticancer activity of novel diphenyl ether-based pyridine derivatives

2018 ◽  
Vol 23 (3) ◽  
pp. 541-554
Author(s):  
Ruchi Verma ◽  
Indira Bairy ◽  
Mradul Tiwari ◽  
G. Varadaraj Bhat ◽  
G. Gautham Shenoy
Keyword(s):  
Anticancer Activity ◽  
In Silico ◽  
Diphenyl Ether ◽  
Pyridine Derivatives ◽  
In Silico Studies

Synthesis and anticancer activity evaluation of benzo[6,7]oxepino[3,2-b] pyridine derivatives

Tetrahedron ◽  
2020 ◽  
Vol 76 (39) ◽  
pp. 131473
Author(s):  
Phanida Thongaram ◽  
Suparerk Borwornpinyo ◽  
Phongthon Kanjanasirirat ◽  
Kedchin Jearawuttanakul ◽  
Mesayamas Kongsema ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Pyridine Derivatives ◽  
Activity Evaluation

Synthesis and In-silico identification of new bioactive 1,3,4-oxadiazole tagged 2,3-dihydroimidazo[1,2-a]pyridine derivatives

2020 ◽  
Vol 16 ◽  
Author(s):  
Bhagwat S. Jadhav ◽  
Vipul P. Purohit ◽  
Ramesh S. Yamgar ◽  
Rajesh S. Kenny ◽  
Suraj N. Mali ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Anticancer Activity ◽  
In Silico ◽  
Antitubercular Activity ◽  
Docking Studies ◽  
Pyridine Derivatives ◽  
Molecular Docking Studies ◽  
New Class ◽  
In Silico Molecular Docking

Background: Tuberculosis (TB) continues to be the most threatening cause of death in recent years. There is urgent need of search more potent, less toxic antitubercular agents. Methods: A set of five new 1,3,4-oxadiazolyl-imidazo-1,2-pyridine derivatives (4a-4e) was synthesized and screened invitro for their antibacterial activity against Mycobacterium tuberculosis (H37 RV strain) ATCC No-27294. Results: Compound 4b displayed potent antitubercular activity at MIC 6.25 µg/mL. In-silico molecular docking studies were performed for evaluation of the binding patterns of compounds 4a-4e in the binding site of proteins like, Pantothenate synthatase and enoyl acyl reductase inhibitor. The outcomes of the in- vitro antitubercular studies were in well agreement with the molecular docking studies. These newly synthesized compounds were found to have good ADMET profile. We also explored possible anticancer activity using in-silico methods. Conclusion: These results shows that readily synthesized 1,3,4-oxadiazolyl-imidazo-1,2-pyridine derivatives (4a-4e) are attracting new class of potent anti-TB targets as well as possible anticancer activity that worth additional opportunities for improvements.

Erratum to: Synthesis and anticancer activity of some new pyridine derivatives

2017 ◽  
Vol 43 (7) ◽  
pp. 4311-4311
Author(s):  
Fatma A. Bassyouni ◽  
Hanaa A. Tawfik ◽  
Abdel Mohsen Soliman ◽  
Mohamed Abdel Rehim
Keyword(s):  
Anticancer Activity ◽  
Pyridine Derivatives

Synthesis and Anticancer Activity of 1,3,4-Oxadiazole-oxazolo[4,5-b]pyridine Derivatives

2020 ◽  
Vol 90 (7) ◽  
pp. 1331-1335
Author(s):  
Suresh Babu Kokkiligadda ◽  
Sivanadh Musunuri ◽  
Bhimcharan Maiti ◽  
M. V. Basaveswara Rao ◽  
Gattu Sridhar
Keyword(s):  
Anticancer Activity ◽  
Pyridine Derivatives

scholarly journals Synthesis and Anticancer Activity of Novel Oxadiazole Functionalized Pyrazolo[3,4-b]pyridine Derivatives

2021 ◽  
Vol 33 (6) ◽  
pp. 1331-1335
Author(s):  
Bhadru Bhukya ◽  
Hanmanthu Guguloth
Keyword(s):  
Breast Cancer ◽  
Cervical Cancer ◽  
Colon Cancer ◽  
Liver Cancer ◽  
Anticancer Activity ◽  
Hydrazine Hydrate ◽  
Pyridine Derivatives ◽  
Aromatic Acids ◽  
Phosphoryl Chloride ◽  
Micromolar Concentration

A series of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives (6a-n)was synthesized using 6-thiophenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (1) through reaction with 2-bromoethyl acetate, followed by hydrazine hydrate to afford hydrazide derivatives (5). These compounds were further treated with aromatic acids in the presence of phosphoryl chloride and obtained oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives (6a-n). All the synthesized compounds 6a-n were screened for anticancer activity against four cancer cell lines such as HeLa - cervical cancer (CCL-2); COLO 205-colon cancer (CCL-222); HepG2-liver cancer (HB-8065); MCF7-breast cancer (HTB-22). Compounds 6i, 6m and 6n were found to have more prominent anticancer activity at micromolar concentration.

Synthesis and anticancer activity of some new pyridine derivatives

2011 ◽  
Vol 38 (7) ◽  
pp. 1291-1310 ◽  
Author(s):  
Fatma A. Bassyouni ◽  
Hanaa A. Tawfik ◽  
Abdel Mohsen Soliman ◽  
Mohamed Abdel Rehim
Keyword(s):  
Anticancer Activity ◽  
Pyridine Derivatives
Sign in / Sign up

Export Citation Format

Share Document