Catalyst-free Synthesis of Spiro[indoline-3,1′-pyrazolo[5,1-a]isoquinolines]viaDiastereoselective 1,3-dipolar Cycloaddition under Mild Conditions

2017 ◽  
Vol 54 (5) ◽  
pp. 2922-2928 ◽  
Author(s):  
Fangzhi Hu ◽  
Hui Chen ◽  
Minmin Zhang ◽  
Shuowen Yu ◽  
Xiaoying Xu ◽  
...  
Keyword(s):  
Dipolar Cycloaddition ◽  
Mild Conditions ◽  
Catalyst Free

A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles: an easy access to five-ring-fused tetrahydroisoquinolines

2017 ◽  
Vol 19 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Xihong Liu ◽  
Dongxu Yang ◽  
Kezhou Wang ◽  
Jinlong Zhang ◽  
Rui Wang
Keyword(s):  
Easy Access ◽  
Dipolar Cycloaddition ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Azomethine Imines

A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles has been reported under mild conditions.

Continuous flow processes for the S-alkynylation of cysteine-containing peptides and thioglycoside under catalyst-free, oxidant-free and mild conditions

2021 ◽  
Author(s):  
Long-Zhou Qin ◽  
Xin Yuan ◽  
Jie Liu ◽  
Meng-yu Wu ◽  
Qi Sun ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Flow Processes ◽  
Novel Method

Herein, we develop a novel method for the selective alkynylation of cysteine-containing peptides and 1-thioglycoside residues by the use of continuous flow. This method was characterised by the mild conditions...

Catalyst-Free Synthesis of N-(1,7-Dioxotetrahydropyrazolo[1,2-a]pyrazol-2-yl)benzamide Derivatives by 1,3-Dipolar Cycloaddition and Rearrangement

Synlett ◽  
2014 ◽  
Vol 25 (08) ◽  
pp. 1093-1096 ◽  
Author(s):  
Yu Xu ◽  
Wenjing Liu ◽  
Xingxia Sun ◽  
Dapeng Lu ◽  
Lijuan Guo
Keyword(s):  
Dipolar Cycloaddition ◽  
Catalyst Free ◽  
Benzamide Derivatives

1,3-Dipolar cycloaddition of nitrones to oxa(aza)bicyclic alkenes

2019 ◽  
Vol 6 (19) ◽  
pp. 3360-3364 ◽  
Author(s):  
Yongqi Yao ◽  
Wen Yang ◽  
Qifu Lin ◽  
Weitao Yang ◽  
Huanyong Li ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Reaction Pathways ◽  
Dipolar Cycloaddition ◽  
Concerted Mechanism ◽  
Mild Conditions

A new 1,3-dipolar cycloaddition of oxa(aza)bicyclic alkenes with nitrones has been developed without any catalyst and additive under mild conditions. The proposed concerted mechanism is investigated by DFT calculations of the reaction pathways.

Anhydrous Conditions Enable the Catalyst‐Free Carboxylation of Aromatic Alkynes with CO 2 under Mild Conditions

2020 ◽  
Vol 103 (2) ◽  
Author(s):  
Davide Toniolo ◽  
Felix D. Bobbink ◽  
Paul J. Dyson ◽  
Marinella Mazzanti
Keyword(s):  
Mild Conditions ◽  
Catalyst Free

Catalyst-free, visible-light-promoted S–H insertion reaction between thiols and α-diazoesters

2020 ◽  
Vol 18 (46) ◽  
pp. 9494-9498
Author(s):  
Jingya Yang ◽  
Ganggang Wang ◽  
Shuwen Chen ◽  
Ben Ma ◽  
Hongyan Zhou ◽  
...  
Keyword(s):  
Visible Light ◽  
Insertion Reaction ◽  
Mild Conditions ◽  
Catalyst Free

A catalyst- and additive-free, visible-light-promoted S–H insertion reaction between thiols and α-diazoesters has been developed under mild conditions.

Facile Synthesis of 4,5-Dihydro-1,3,4-Thiadiazoles by 1,3-Dipolar Cycloaddition of Thioisomünchnones

2009 ◽  
Vol 62 (4) ◽  
pp. 356 ◽  
Author(s):  
Bárbara Sánchez ◽  
José Luis Bravo ◽  
María Josí Arívalo ◽  
Ignacio López ◽  
Mark E. Light ◽  
...  
Keyword(s):  
Structure Analysis ◽  
Structure Elucidation ◽  
Room Temperature ◽  
Dipolar Cycloaddition ◽  
Two Dimensional ◽  
Facile Synthesis ◽  
X Ray ◽  
Mild Conditions ◽  
Nmr Techniques

The present paper summarizes a straightforward synthesis of 4,5-dihydro-1,3,4-thiadiazoles by the 1,3-dipolar cycloaddition of thioisomünchnones. These reactions have been carried out in dichloromethane and are essentially complete within 60 min at room temperature. Under such mild conditions the asymmetric version has been explored as well. Unequivocal structure elucidation has been accomplished by means of one- and two-dimensional NMR techniques as well as X-ray structure analysis.

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