Catalysis in Transamination of 6‐chloro‐2‐(3‐chlorophenyl)‐1 H ‐benz[ de ]isoquinoline‐1,3‐(2 H )‐dione and its Implications in Laser Tissue Welding

2017 ◽  
Vol 54 (3) ◽  
pp. 2029-2037 ◽  
Author(s):  
Samantha M. Anderson ◽  
Stanford D. Mitchell ◽  
Kayla A. LaPlante ◽  
Ryan K. McKenney ◽  
David E. Lewis
Keyword(s):  
Tissue Welding ◽  
Laser Tissue Welding

In Vivo Laser Tissue Welding in the Rabbit Maxillary Sinus

2008 ◽  
Vol 22 (6) ◽  
pp. 625-628 ◽  
Author(s):  
Benjamin S. Bleier ◽  
James N. Palmer ◽  
Michael A. Gratton ◽  
Noam A. Cohen
Keyword(s):  
Intracranial Pressure ◽  
Maxillary Sinus ◽  
Skull Base ◽  
Thermal Injury ◽  
Surrounding Tissue ◽  
Csf Leak ◽  
Tissue Welding ◽  
Laser Tissue Welding ◽  
And Control

Background One of the challenges in the current expansion of endoscopic sinonasal surgery is the ability to adequately reconstruct the skull base. Laser tissue welding (LTW) uses laser energy coupled to a biological solder to produce tissue bonds with burst thresholds exceeding human intracranial pressure. This technology could be used to reduce the rate of postoperative cerebrospinal fluid (CSF) leak. We performed this study to determine whether LTW can create durable tissue bonds in sinonasal mucosa that support normal wound healing and produce minimal collateral thermal injury. Methods Bilateral maxillary sinus mucosal incisions were made in 20 New Zealand white rabbits and one side was repaired using LTW. Burst pressure thresholds were measured on postoperative days 0, 5, and 15 and were compared with control using a two- way ANOVA and a post hoc Tukey test. Welds were examined histologically for thermal injury, inflammation, and fibroplasia and graded on a 4-point scale by three blinded observers. Results The burst pressures of the LTW group were significantly higher than control on postoperative day 0 (120.85 mm Hg, N = 4, SD = 47.84 versus 7.85 mm Hg, N = 4, SD = 0.78), and day 5 (132.56 mm Hg, N = 8, SD = 24.02 versus 41.7 mm Hg, N = 8, SD = 7.2; p < 0.05). By postoperative day 15 there was no significant difference between LTW (169.64 mm Hg, N = 8, SD = 18.49) and control (160.84 mm Hg, N = 8, SD = 14.16) burst thresholds. There was no evidence of thermal injury to the surrounding tissue in any group as well as no difference between experimental group and control with respect to inflammation or fibroplasia. Conclusion This is the first in vivo study showing that LTW is capable of producing tissue bonds exceeding human intracranial pressure with negligible thermal injury in sinonasal tissue. Welding can be performed endoscopically using a fiberoptic cable and may be useful in CSF leak and skull base repair.

Laser Tissue Welding

2003 ◽  
Author(s):  
Karen McNally-Heintzelman ◽  
Ashley Welch
Keyword(s):  
Tissue Welding ◽  
Laser Tissue Welding

scholarly journals Temperature measurements during laser tissue welding process

2012 ◽  
Author(s):  
T. Piatkowski ◽  
A. Zajac ◽  
H. Polakowski ◽  
M. Kastek
Keyword(s):  
Welding Process ◽  
Temperature Measurements ◽  
Tissue Welding ◽  
Laser Tissue Welding

Fluorescence Spectroscopic Imaging to Detect Changes in Collagen and Elastin Following Laser Tissue Welding

2000 ◽  
Vol 18 (1) ◽  
pp. 3-8 ◽  
Author(s):  
JING TANG ◽  
FANAN ZENG ◽  
HOWARD SAVAGE ◽  
PENG PEI HO ◽  
R.R. ALFANO
Keyword(s):  
Spectroscopic Imaging ◽  
Tissue Welding ◽  
Laser Tissue Welding

Local microcirculation disorders in uterus under laser tissue welding and their influence in the healing process

1994 ◽  
Author(s):  
Valentine I. Kozlov ◽  
Oleg K. Skobelkin ◽  
Ildar Fatkullin ◽  
Oleg A. Terman ◽  
Gennadii Chizhov ◽  
...  
Keyword(s):  
Healing Process ◽  
Tissue Welding ◽  
Laser Tissue Welding

Investigation of Laser Tissue Welding Dynamics via Experiment and Modeling

1997 ◽  
Vol 15 (1) ◽  
pp. 3-7 ◽  
Author(s):  
WARD SMALL ◽  
DUNCAN J. MAITLAND ◽  
NICHOLAS J. HEREDIA ◽  
DAVID C. EDER ◽  
PETER M. CELLIERS ◽  
...  
Keyword(s):  
Tissue Welding ◽  
Laser Tissue Welding
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