Prognostic value of adjacent organ resection in patients with left‐sided pancreatic ductal adenocarcinoma following distal pancreatectomy

2019 ◽  
Vol 26 (6) ◽  
pp. 227-234 ◽  
Author(s):  
Ki Byung Song ◽  
Jaewoo Kwon ◽  
Yong Woon Kim ◽  
Dae Wook Hwang ◽  
Jae Hoon Lee ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Distal Pancreatectomy ◽  
Prognostic Value ◽  
Ductal Adenocarcinoma ◽  
Adjacent Organ

scholarly journals High JAK2 Protein Expression Predicts a Poor Prognosis in Patients with Resectable Pancreatic Ductal Adenocarcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yang Song ◽  
Mei-Yue Tang ◽  
Wei Chen ◽  
Zhe Wang ◽  
Si-Liang Wang
Keyword(s):  
Protein Expression ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Poor Prognosis ◽  
Prognostic Value ◽  
Survival Curve ◽  
Clinicopathological Features ◽  
Ductal Adenocarcinoma ◽  
Clinicopathological Analysis ◽  
Primary Focus ◽  
The Relationship

Background. Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies worldwide. The JAK/STAT signaling pathway is involved in pancreatic cancer tumorigenesis. However, the prognostic value of JAK2 expression in resectable PDAC is unclear. Method. In this study, we performed a clinicopathological analysis of 62 resectable PDAC cases with a primary focus on survival. JAK2 expression was examined by immunohistochemistry. The relationship between JAK2 expression and clinicopathological features and prognosis was analyzed. Results. Survival curve analyses revealed that high levels of JAK2 expression predict a poor prognosis in resectable PDAC patients. Multivariate analysis confirmed that JAK2 expression can predict the prognosis of PDAC. Conclusions. Assessment of JAK2 protein expression may be a promising method to predict prognosis in patients with resectable PDAC.

scholarly journals Prognostic Value of CT Radiomic Features in Resectable Pancreatic Ductal Adenocarcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Farzad Khalvati ◽  
Yucheng Zhang ◽  
Sameer Baig ◽  
Edrise M. Lobo-Mueller ◽  
Paul Karanicolas ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Value ◽  
Ductal Adenocarcinoma

Expression profile and prognostic value of SAV1 in patients with pancreatic ductal adenocarcinoma

Tumor Biology ◽  
2016 ◽  
Vol 37 (12) ◽  
pp. 16207-16213 ◽  
Author(s):  
Lei Wang ◽  
Yu Wang ◽  
Peng-Ping Li ◽  
Rui Wang ◽  
Yue Zhu ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Expression Profile ◽  
Prognostic Value ◽  
Ductal Adenocarcinoma

scholarly journals Neutrophil–lymphocyte ratio (NLR) was associated with prognosis and immunomodulatory in patients with pancreatic ductal adenocarcinoma (PDAC)

2020 ◽  
Vol 40 (6) ◽  
Author(s):  
Zi-jun Xiang ◽  
Tao Hu ◽  
Yun Wang ◽  
Hao Wang ◽  
Lin Xu ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Surgical Resection ◽  
Immune Cells ◽  
Prognostic Value ◽  
Roc Curves ◽  
T Cell Subsets ◽  
Ductal Adenocarcinoma ◽  
Survival Prediction ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Abstract Although the oncological outcomes in patients with pancreatic ductal adenocarcinoma (PDAC) have markedly improved over the past decade, the survival prediction is still challenging. The aim of this study was to investigate the prognostic value of neutrophil–lymphocyte ratio (NLR) and analyze the relationship of between the NLR and immune cells phenotypes in patients with PDAC. Sixty-seven consecutive patients with PDAC were recruited in this study. Life-table estimates of survival time were calculated according to the Kaplan and Meier methodology. The phenotypic T cells subclasses were evaluated by flow cytometry. All the 67 patients in this study were treated with surgical resection and among them, 46 patients received adjuvant chemotherapy. Receiver operating characteristic (ROC) curves analysis was performed to compare prognostic value of NLR with CA199. We found that the Harrell's area under ROC (AUROC) for the NLR to predict overall survival (OS) (0.840; 95% CI, 0.766–0.898) was significantly higher than that of the CA199 levels. After that we stratified all patients into NLR > 2.5 (n = 42) and NLR ≤ 2.5 (n = 25) groups according to the OS of patients with PDAC. Survival analysis showed that patients with NLR ≤ 2.5 had significantly favorable OS and progressive free survival (PFS) compared with patients with NLR > 2.5. The CD3+ and CD8+/CD28+ T cell subsets were significantly increased in patients with NLR ≤ 2.5 (P<0.05), while the CD8+/CD28- and CD4+/CD25+ cell subsets were significantly decreased in patients with NLR ≤ 2.5 (P<0.05). In conclusion, a high NLR value independently predicts poor survival in patients with PDAC after surgical resection. The NLR was closely related with immune cells phenotypes The NLR may help oncologists evaluate outcomes of patients received surgical resection and chemotherapy to choose alternative therapies for patients with high NLR value.

scholarly journals Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (27) ◽  
pp. 40992-41004 ◽  
Author(s):  
Angela Diana ◽  
Lai Mun Wang ◽  
Zenobia D’Costa ◽  
Paul Allen ◽  
Abul Azad ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Value ◽  
Ductal Adenocarcinoma ◽  
Desmoplastic Stroma
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