Clinical implication of serum carcinoembryonic antigen and carbohydrate antigen 19-9 for the prediction of malignancy in intraductal papillary mucinous neoplasm of pancreas

2015 ◽  
Vol 22 (9) ◽  
pp. 699-707 ◽  
Author(s):  
Jae Ri Kim ◽  
Jin-Young Jang ◽  
Mee Joo Kang ◽  
Taesung Park ◽  
Seung Yeoun Lee ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Clinical Implication ◽  
Carbohydrate Antigen ◽  
Mucinous Neoplasm ◽  
Serum Carcinoembryonic Antigen

scholarly journals Limits of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 as the diagnosis of gallbladder cancer

2021 ◽  
Vol 25 (1) ◽  
pp. S309-S309
Author(s):  
Jae Seung KANG ◽  
Yoo Jin CHOI ◽  
Yoonhyeong BYUN ◽  
Youngmin HAN ◽  
Jung Min LEE ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Carcinoembryonic Antigen ◽  
Carbohydrate Antigen ◽  
Serum Carcinoembryonic Antigen

scholarly journals Limited usefulness of serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels for gastrointestinal and whole-body cancer screening

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Masau Sekiguchi ◽  
Takahisa Matsuda
Keyword(s):  
Cancer Screening ◽  
Carcinoembryonic Antigen ◽  
Diagnostic Performance ◽  
Carbohydrate Antigen ◽  
Serum Markers ◽  
Multiple Organ ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Serum Carcinoembryonic Antigen ◽  
Limited Usefulness

Abstract The diagnostic performance of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels for multiple-organ cancer screening has not been fully elucidated. However, they are widely used for real-world opportunistic screening of multiple-organ cancers. This study aimed to examine the diagnostic performance of these serum markers in multiple-organ cancer screening. Data from asymptomatic individuals subjected to opportunistic cancer screening were analyzed. The diagnostic performance of CEA and CA 19-9 was assessed for (A) upper/lower gastrointestinal cancers and (B) whole-body cancers (including both gastrointestinal and other organ cancers) using the results of upper/lower gastrointestinal endoscopy and whole-body imaging as reference. Data from 12,349 and 7616 screened individuals were used to assess the diagnostic performance of CEA and CA 19-9 for (A) and (B), respectively. For (A), the sensitivity and positive predictive value (PPV) of CEA (cut-off: 5 ng/mL) were 7.8% and 3.7%, respectively; those of CA19-9 (cut-off: 37 U/mL) were 7.4% and 2.7%, respectively. For (B), the sensitivity and PPV of CEA were 6.6% and 4.1%, respectively, and those of CA19-9 were 10.8% and 5.8%, respectively. Considering even multiple cancers, the sensitivity and PPV of CEA and CA 19-9 were low, thus confirming their limited usefulness in multiple-organ cancer screening.

Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Immunostaining in Benign Multicystic Mesothelioma of the Peritoneum

2001 ◽  
Vol 125 (7) ◽  
pp. 944-947
Author(s):  
Robert N. N. Holtzman ◽  
A. Douglas Heymann ◽  
Fausto Bordone ◽  
Gianfilippo Marinoni ◽  
Paolo Barillari ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Liver Cyst ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Imaging Studies ◽  
Cancer Antigen 125 ◽  
Mesothelial Cyst ◽  
Serum Carcinoembryonic Antigen ◽  
Benign Multicystic Mesothelioma

Abstract A 58-year-old Italian man was incidentally discovered to have an elevated carbohydrate antigen 19-9 (CA-19-9) level of 132 U/mL on routine blood testing. Multisystem imaging studies revealed multiple benign-appearing cysts of the liver and single cysts in the pancreas and kidney parenchyma. Throughout 14 months, fluctuations were observed in the elevated serum CA-19-9 levels from 99 to 450 U/mL. Serum carcinoembryonic antigen (CEA) and other tumor markers were normal. Laparoscopy disclosed multiple cystic lesions on the surface of the liver, on the serosal surface of the ileum, and in the mesentery. Electron microscopy characterized the cells as mesothelial. The pathologic diagnosis was benign multicystic mesothelioma of the peritoneum (BMMP). Aspirated fluid from the liver cyst revealed CA-19-9 levels at 28 500 U/mL, strongly linking the elevated serum CA-19-9 levels with mesothelial cyst secretion. Immunostaining was positive for CA-19-9, CEA, and cancer antigen 125 (CA-125). We believe this is the first documented instance of CA-19-9 and CEA secretion in BMMP.

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