scholarly journals Clinical Characteristics of Pancreatic and Biliary Tract Cancers Associated with Lynch Syndrome

2021 ◽  
Author(s):  
Shigemasa Takamizawa ◽  
Chigusa Morizane ◽  
Noriko Tanabe ◽  
Yuta Maruki ◽  
Shunsuke Kondo ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Biliary Tract ◽  
Clinical Characteristics ◽  
Biliary Tract Cancers

Different clinical characteristics in biliary tract cancers

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 4215-4215
Author(s):  
M. A. Lee ◽  
I. S. Woo ◽  
J. H. Kang ◽  
Y. S. Hong ◽  
K. S. Lee ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Clinical Characteristics ◽  
Biliary Tract Cancers

scholarly journals A Population-Based Retrospective Study of Biliary Tract Cancers in Alberta, Canada

2021 ◽  
Vol 28 (1) ◽  
pp. 417-427
Author(s):  
Carissa Beaulieu ◽  
Arthur Lui ◽  
Dimas Yusuf ◽  
Zainab Abdelaziz ◽  
Brock Randolph ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Demographic Data ◽  
Performance Status ◽  
Single Agent ◽  
Eastern Cooperative Oncology Group ◽  
Intrahepatic Bile Duct ◽  
Population Based ◽  
Phase Iii ◽  
First Line ◽  
Biliary Tract Cancers

Background: Biliary tract cancers (BTC) are uncommon malignancies and are underrepresented in the literature. Methods: We performed a retrospective population-based review of adult patients with biopsy-confirmed BTC in Alberta from 2000 to 2015. Demographic data, risk factors, symptoms, treatment, and staging data were collected and analyzed. Survival analyses were completed. Results: A total of 1604 patients were included in our study, of which 766 (47.8%) were male. The median age at diagnosis was 68 (range 19–99). There were 374 (23.3%) patients with resectable tumors at diagnosis versus 597 (37.2%) with unresectable tumors. Of the patients, 380 (21.5%) received chemotherapy (CT) and 81 (5.0%) underwent radiation therapy. There was a clear trend with worsening stage and performance status associated with shorter median overall survival (OS). Ampulla of Vater tumors had the best median OS (25.69 months), while intrahepatic bile duct cancers had the worst (5.78 months). First-line palliative CT regimens included gemcitabine+cisplatin (OS 14.98 months (mo), n = 212), single agent gemcitabine (OS 12.42 mo, n = 22), capecitabine (OS 8.12 mo, n = 8), and capecitabine+gemcitabine (OS 6.93 mo, n = 13). Patients with advanced or metastatic disease who received first-line gemcitabine+cisplatin had a median OS of 11.8 months (n = 119). Conclusion: BTCs have poor survival. Worse outcomes occur in higher stage and poorer Eastern Cooperative Oncology Group (ECOG) performance status patients across all tumor subtypes. Tumor resectability at diagnosis was associated with better OS. Our study supports the use of gemcitabine+cisplatin as a combination first-line palliative CT, as patients treated in Alberta have a comparable OS to that reported in the ABC-02 phase III study.

scholarly journals Synergistic Combination of Cytotoxic Chemotherapy and Cyclin Dependent Kinase 4/6 Inhibitors in Biliary Tract Cancers

Hepatology ◽  
2021 ◽  
Author(s):  
Mansi Arora ◽  
James M. Bogenberger ◽  
Amro M. Abdelrahman ◽  
Jennifer Yonkus ◽  
Roberto Alva‐Ruiz ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Cytotoxic Chemotherapy ◽  
Cyclin Dependent Kinase ◽  
Biliary Tract Cancers ◽  
Synergistic Combination

scholarly journals Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers

JAMA Oncology ◽  
2019 ◽  
Vol 5 (6) ◽  
pp. 824 ◽  
Author(s):  
Rachna T. Shroff ◽  
Milind M. Javle ◽  
Lianchun Xiao ◽  
Ahmed O. Kaseb ◽  
Gauri R. Varadhachary ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancers

Addition of an antiangiogenic therapy, bevacizumab, to gemcitabine plus oxaliplatin improves survival in advanced biliary tract cancers

2017 ◽  
Vol 36 (1) ◽  
pp. 156-162 ◽  
Author(s):  
Marie Bréchon ◽  
Marie Dior ◽  
Johann Dréanic ◽  
Bertrand Brieau ◽  
Marie-Anne Guillaumot ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Antiangiogenic Therapy ◽  
Biliary Tract Cancers

scholarly journals Adjuvant chemotherapy for resected biliary tract cancers: a systematic review and meta-analysis

HPB ◽  
2017 ◽  
Vol 19 (9) ◽  
pp. 741-748 ◽  
Author(s):  
Michele Ghidini ◽  
Gianluca Tomasello ◽  
Andrea Botticelli ◽  
Sandro Barni ◽  
Giampietro Zabbialini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adjuvant Chemotherapy ◽  
Biliary Tract ◽  
Meta Analysis ◽  
Biliary Tract Cancers

Current and emerging therapies for advanced biliary tract cancers

2021 ◽  
Vol 6 (11) ◽  
pp. 956-969
Author(s):  
Audrey E Kam ◽  
Ashiq Masood ◽  
Rachna T Shroff
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancers ◽  
Emerging Therapies
Sign in / Sign up

Export Citation Format

Share Document