scholarly journals Second primary malignancies in chronic lymphocytic leukaemia: Skin, solid organ, haematological and Richter's syndrome

eJHaem ◽  
2021 ◽  
Author(s):  
Yandong Shen ◽  
Luke Coyle ◽  
Ian Kerridge ◽  
William Stevenson ◽  
Christopher Arthur ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Second Primary ◽  
Solid Organ ◽  
Second Primary Malignancies ◽  
Richter’S Syndrome

scholarly journals Second Primary Malignancies in Chronic Lymphocytic Leukaemia; Skin, Solid Organ, Haematological, and Richter's Syndrome

2021 ◽  
Author(s):  
Yandong Shen ◽  
Luke Coyle ◽  
Ian Kerridge ◽  
William Stevenson ◽  
Christopher Arthur ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Cell Carcinoma ◽  
Lymphocytic Leukaemia ◽  
High Rate ◽  
Second Primary ◽  
Solid Organ ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Second Primary Malignancies ◽  
Richter’S Syndrome

Chronic lymphocytic leukaemia (CLL) is invariably accompanied by some degree of immune failure. CLL patients have a high rate of second primary malignancy (SPM) compared to the general population. We comprehensively documented the incidence of all forms of SPM including skin cancer (SC), solid organ malignancy (SOM), second haematological malignancy (SHM), and separately Richter's Syndrome (RS) across all therapy eras. Among the 517 CLL/SLL patients, the overall incidence of SPMs with competing risks were SC 31.07%, SOM 25.99%, SHM 5.19% and RS 7.55%. Melanoma accounted for 30.3% of SC. Squamous cell carcinoma (SCC), including 8 metastatic SCCs, was 1.8 times more than basal cell carcinoma (BCC), a reversal of the typical BCC:SCC ratio. The most common SOM were prostate (6.4%) and breast (4.5%). SHM included 7 acute myeloid leukaemia and 5 myelodysplasia of which 8 were therapy-related. SPMs are a major health burden with 44.9% of CLL patients with at least one, and apart from SC, associated with significantly reduced overall survival. Dramatic improvements in CLL treatment and survival have occurred with immunochemotherapy and targeted therapies but mitigating SPM burden will be important to sustain further progress.  

scholarly journals The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Teng Fong Ng ◽  
Benedict Carnley ◽  
Celia Green ◽  
Dominic Spagnolo ◽  
Michael F. Leahy
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
B Lymphocytes ◽  
Lymphocytic Leukaemia ◽  
Aggressive Lymphoma ◽  
Treatment Regimens ◽  
Slow Growing ◽  
Richter’S Syndrome

Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter’s syndrome. While Richter’s syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter’s syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic.

scholarly journals Solid organ transplant in individuals with monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia

2015 ◽  
Vol 174 (1) ◽  
pp. 162-165 ◽  
Author(s):  
Paolo Strati ◽  
Kamel A. Gharaibeh ◽  
Nelson Leung ◽  
Ferdinando G. Cosio ◽  
Timothy G. Call ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
B Cell ◽  
Lymphocytic Leukaemia ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ

Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukaemia treated with cladribine

2004 ◽  
Vol 40 (3) ◽  
pp. 383-389 ◽  
Author(s):  
T. Robak ◽  
J.Z. Blonski ◽  
J. Gora-Tybor ◽  
M. Kasznicki ◽  
L. Konopka ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Second Malignancies ◽  
Richter’S Syndrome

Richter's syndrome in a case of atypical chronic lymphocytic leukaemia with the t(11;14)(q13;q32): role for a p53 exon 7 gene mutation

1996 ◽  
Vol 92 (2) ◽  
pp. 375-381 ◽  
Author(s):  
Antonio Cuneo ◽  
Cristiano De Angeli ◽  
Maria Grazia Roberti ◽  
Nadia Piva ◽  
Renato Bigoni ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Gene Mutation ◽  
Lymphocytic Leukaemia ◽  
Richter’S Syndrome

Adenoid cystic carcinoma and chronic lymphocytic leukaemia: synchronous presentations in the lung

2021 ◽  
Vol 14 (2) ◽  
pp. e236074
Author(s):  
Philip S Webb ◽  
Yu Zhi Zhang ◽  
Kirsten Burrell ◽  
Georges Sinclair
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Adenoid Cystic Carcinoma ◽  
Lymphocytic Leukaemia ◽  
Solid Organ ◽  
Lung Tumours ◽  
Active Smoker ◽  
Adenoid Cystic ◽  
History Of ◽  
Local Lymph Node ◽  
Solid Organ Malignancy

A 59-year-old male active smoker presented with a 6-month history of cough and breathlessness and was found to have a right upper lobe mass. Histology revealed this to be an adenoid cystic carcinoma (ACC) of the lung, while local lymph node dissection revealed a synchronous diagnosis of chronic lymphocytic leukaemia (CLL). The connection between CLL and solid organ malignancy is well documented, but the reporting of ACC in this context is novel. Mechanisms linking the two processes are revealed with the possibility of causality, and heightened vigilance for the development of primary lung tumours in CLL, and their management, is recommended.

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