Cytopenia associated with copper deficiency

Copper deficiency can cause cardiovascular lesions in experimental animals. Previous experiments have shown that the biochemical and itDrphologic lesions induced by deprivation of dietary copper can be suppressed by feeding diets containing starch or can be magnified by a high sucrose diet. In a recent study it was found that the more severe signs of copper deficiency in rats fed sucrose as compared to starch were due to the fructose moiety of sucrose. Although fructose as compared to starch markedly enhanced the symptoms of copper deficiency, the possibility that an effect of dietary carbohydrates due to the nature of the simple carbohydrate (fructose vs glucose) cannot be excluded. The present study was designed to determine if the severity of copper deficiency in rats fed sucrose as compared to starch is due to the glucose as well as the fructose moiety of sucrose. This portion of the study assessed the morphologic changes in aortas of seventy weanling male rats who were fed, for 9 weeks, copper deficient or copper supplemented diets containing either 62% starch, fructose or glucose. The starch-fed copper supplemented group served as the most normal controls. Rats were sacrificed after 9 weeks of dietary treatments. Copper deficiency was verified by reduced serum ceruloplasmin activity and serum and hepatic copper concentration.

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Abstract #337: A Rare Case of Copper Deficiency and Celiac Disease

Endocrine Practice ◽

10.1016/s1530-891x(20)44083-2 ◽

2006 ◽

Vol 12 ◽

pp. 96-97

Author(s):

Mihaela Cosma ◽

Daniel L. Hurley

Keyword(s):

Celiac Disease ◽

Rare Case ◽

Copper Deficiency

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Pancytopenia in a child with cystic fibrosis and severe copper deficiency: Insight from bone marrow evaluation

Pediatric Blood & Cancer ◽

10.1002/pbc.29276 ◽

2021 ◽

Author(s):

Maggie D. Seblani ◽

Susanna A. McColley ◽

Shunyou Gong ◽

Lee M. Bass ◽

Sherif M. Badawy

Keyword(s):

Cystic Fibrosis ◽

Bone Marrow ◽

Copper Deficiency ◽

Bone Marrow Evaluation

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The Occurrence of Conditioned and Simple Copper Deficiency in Cattle and Sheep in Setesdalen, a Valley in the Southern Part of Norway II

Acta Veterinaria Scandinavica ◽

10.1186/bf03547358 ◽

1961 ◽

Vol 2 (1) ◽

pp. 375-398

Author(s):

Gustav N. Havre ◽

Olav Dynna

Keyword(s):

Copper Deficiency ◽

Cattle And Sheep

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A case of Menkes syndrome with pyloric stenosis: An effect of copper deficiency on NOS1?

Journal of Inherited Metabolic Disease ◽

10.1023/a:1005487027838 ◽

1999 ◽

Vol 22 (2) ◽

pp. 197-198 ◽

Cited By ~ 2

Author(s):

S. Cunningham ◽

P. M. Crofton ◽

T. G. Marshall ◽

D. R. Fitzpatrick

Keyword(s):

Pyloric Stenosis ◽

Copper Deficiency ◽

Effect Of Copper

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Erythropoietin-Resistant Anemia Secondary to Zinc-Induced Hypocupremia in a Hemodialysis Patient

Case Reports in Nephrology and Dialysis ◽

10.1159/000512612 ◽

2021 ◽

pp. 167-175

Author(s):

Stephanie Munie ◽

Pairach Pintavorn

Keyword(s):

Copper Deficiency ◽

Hemodialysis Patient ◽

Esrd Patient ◽

Serological Testing ◽

Zinc Supplement ◽

Excessive Intake ◽

Stage Renal Disease ◽

End Stage ◽

Work Up ◽

Excess Zinc

Excessive intake of zinc is a known but often forgotten cause of copper deficiency, and its consequences in the context of end-stage renal disease (ESRD) are not widely discussed. Zinc-induced copper deficiency (ZICD) can result in erythropoietin (EPO)-resistant anemia and may not be considered as a possible etiology when conducting the work-up. We present a case wherein an ESRD patient had been receiving excess zinc for several months and subsequently experienced EPO-resistant anemia. Our patient’s GI work-up was negative, and increased doses of iron and EPO-stimulating agent were ineffective. She underwent a bone marrow biopsy and more serological testing. She was ultimately diagnosed with ZICD, and cessation of her zinc supplement and initiation of copper replacement proved effective in restoring EPO responsiveness. Awareness of ZICD as a possible factor in EPO-resistant anemia could lead to an expedited diagnosis and avoid an unnecessary and extensive work-up.

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