scholarly journals Does COVID‐19 really impact on the oxy‐hemoglobin dissociation curve?

eJHaem ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 604-607
Author(s):  
Flávia Nóbrega ◽  
Vitor Augusto Queiroz Mauad ◽  
Davimar Miranda Maciel Borducchi
Keyword(s):  
Dissociation Curve

The Disappearance of Heparin Activity with Liver Globulins and Determinations of Heparinase

1963 ◽  
Vol 10 (01) ◽  
pp. 071-080 ◽  
Author(s):  
L. B Jaques ◽  
C Mary Jaques
Keyword(s):  
Anticoagulant Activity ◽  
Rabbit Liver ◽  
Dissociation Curve ◽  
Ph Values ◽  
Phenol Extraction ◽  
Progressive Loss ◽  
Heparin Activity

SummaryPreparations were made of rabbit liver globulin by the method of Jaques for heparinase and their effect on heparin studied. The results confirmed the observations of a progressive loss of anticoagulant activity with globulin in 0.9% saline, of a loss of metachromatic activity after phenol extraction and the reversal of the latter by alkali. The latter observations were due to the solubility in phenol of heparin on combination with protein. With suitable preparations, a decrease in anticoagulant activity without decrease in metachromatic activity was observed, i.e. conversion of heparin to uroheparin. Loss of heparin due to combination with protein and resulting precipitation, solubility in phenol, etc. followed a protein pH-dissociation curve. Loss of heparin anticoagulant activity due to heparinase was maximal at pH 5.4. No loss of heparin occurred at pH values more acid than 5 or more alkaline than 7.

A development of the oxyhemoglobin dissociation curve analyzer

1976 ◽  
Vol 41 (2) ◽  
pp. 259-267 ◽  
Author(s):  
C. E. Hahn ◽  
P. Foex ◽  
C. M. Raynor
Keyword(s):  
Dissociation Curve ◽  
Oxyhemoglobin Dissociation Curve ◽  
Electrode Performance ◽  
Oxyhemoglobin Dissociation

The development and improvement of an oxyhemoglobin dissociation curve analyzer is described. PO2 electrode performance was improved by electrochemical means and circuits are described for processing the PO2 and pH signalsfrom the analyzer. A circuit for automatically correcting the curve for Bohr shifts from pH 7.40 is described, and the performance of the Bohr shift unit is verified by experiment. The analyzer produces curves under standard conditions of PCO2 40 mmHg, pH 7.40, and 37 degrees C.

scholarly journals THE CARBON DIOXIDE DISSOCIATION CURVE OF LIVING MAMMALIAN MUSCLE

1932 ◽  
Vol 95 (1) ◽  
pp. 95-113 ◽  
Author(s):  
Laurence Irving ◽  
H.C. Foster ◽  
J.K.W. Ferguson
Keyword(s):  
Carbon Dioxide ◽  
Dissociation Curve ◽  
Mammalian Muscle ◽  
Carbon Dioxide Dissociation Curve

scholarly journals THE HYDROGEN ION DISSOCIATION CURVE OF β-LACTOGLOBULIN

1942 ◽  
Vol 142 (2) ◽  
pp. 803-822 ◽  
Author(s):  
R. Keith Cannan ◽  
Albert H. Palmer ◽  
Andre C. Kibrick
Keyword(s):  
Hydrogen Ion ◽  
Dissociation Curve ◽  
Ion Dissociation ◽  
Β Lactoglobulin

Dissociation curve of bird blood and effect of red cell oxygen consumption

1973 ◽  
Vol 17 (3) ◽  
pp. 269-275 ◽  
Author(s):  
P.L. Lutz ◽  
I.S. Longmuir ◽  
J.V. Tuttle ◽  
K. Schmidt-Nielsen
Keyword(s):  
Oxygen Consumption ◽  
Red Cell ◽  
Dissociation Curve

scholarly journals Comparison of Cerebrovascular Response to Hypoxic and Carbon Monoxide Hypoxia in Newborn and Adult Sheep

1984 ◽  
Vol 4 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Raymond C. Koehler ◽  
Richard J. Traystman ◽  
Scott Zeger ◽  
Mark C. Rogers ◽  
M. Douglas Jones
Keyword(s):  
Carbon Monoxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Age Groups ◽  
Hypoxic Hypoxia ◽  
Dissociation Curve ◽  
Oxyhemoglobin Dissociation Curve ◽  
Adult Sheep ◽  
Control Value ◽  
Oxyhemoglobin Dissociation

Cerebral blood flow (CBF) responses to two types of isocapnic hypoxia, hypoxic hypoxia (HH) and carbon monoxide hypoxia (COH), were examined in seven unanesthetized adult sheep by the radiolabeled microsphere technique. Comparisons were made with newborn lambs (5–12 days old) previously studied under similar conditions. The arterial O2 content (Cao2) was reduced in a graded manner to 50–60% of the control value. During HH, CBF increased to maintain cerebral O2 delivery (Cao2 x CBF) in both adults and newborns; however, cerebral O2 uptake (CMRO2) did not change. Although CMRO2 was higher in newborns, the responses of CBF/CMRO2 to HH did not differ significantly in newborns and adults. In newborns, regional CBF showed that brainstem areas were particularly responsive to HH. In both age groups, CBF increased to a greater extent with COH than with HH for similar reductions in Cao2. This resulted in an increase in cerebral O2 delivery with COH. The degree to which COH differed from HH correlated with the magnitude of the leftward shift of the oxyhemoglobin dissociation curve that accompanies COH. In adults, CMRO2 fell by 16% with COH but was maintained in newborns. We conclude that maintenance of cerebral O2 delivery during acute, isocapnic HH is a property of CBF regulation common to both newborn and adult sheep. During COH, the position of the oxyhemoglobin dissociation curve is an additional factor that sets the level of O2 delivery. The fetal conditions of low Cao2 and a left-shifted oxyhemoglobin dissociation curve may have provided the newborn with a microcirculation better suited for maintaining CMRO2 during COH.

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