Enhanced therapeutic efficacy of oncolytic herpes vector G207 against human non-small cell lung cancer—expression of an RNA-binding protein, Musashi1, as a marker for the tailored gene therapy

2006 ◽  
Vol 8 (11) ◽  
pp. 1329-1340 ◽  
Author(s):  
Ryuichi Kanai ◽  
Keisuke Eguchi ◽  
Miwa Takahashi ◽  
Steven Goldman ◽  
Hideyuki Okano ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Therapeutic Efficacy ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer

2018 ◽  
Vol 98 (12) ◽  
pp. 1562-1574 ◽  
Author(s):  
Elena Martínez-Terroba ◽  
Teresa Ezponda ◽  
Cristina Bértolo ◽  
Cristina Sainz ◽  
Ana Remírez ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Small Cell ◽  
Small Cell Lung

The combination of unique biomolecules and nanoparticles has shown successful gene therapy treatment approaches for non-small cell lung cancer treatment

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Lung Cancer ◽  
Gene Therapy ◽  
Clinical Trials ◽  
Gene Delivery ◽  
Cancer Treatment ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Therapeutic Efficacy ◽  
Small Cell ◽  
Small Cell Lung

Using nanotechnology-based drug delivery systems can solve some of the drawbacks of conventional cancer treatment, such as non-specific targeting, solubility difficulties, and poor entry of chemotherapeutic drugs into cancer cells. Over the last two decades, a combination of unique biomolecules and nanoparticles has shown successful treatment approaches for Non-small cell lung cancer (NSCLC) treatment. Targeted gene delivery employing lipid, polymer or metal-based nanoparticles showed positive in vivo and in vitro experimental findings with therapeutic efficacy. Gene therapy has shown enhanced transfection efficiency and targeting potential for various NSCLC cell lines when delivered locally or systemically. Despite this, there are a number of barriers to nanoparticle-mediated gene therapy, including ensuring the stability of biomolecules and nanoparticles during delivery, managing their biodistribution, and reducing the possible adverse effects of nanoparticles. These difficulties must be handled before clinical trials begin. Evaluation of therapeutic efficacy as well as inspection criteria for nanoparticles in gene therapy must be devised to widen the use of nano-gene therapy in cancer treatment. Advanced models, algorithms, and simulations to anticipate nanoparticles' biodistribution, design, and kinetics will be needed in the future to decrease the barrier to nanoparticles in clinical trials. Using new technologies and software, nanoparticles with increased selectivity, increased loading capacity, long circulation periods and effective influx into the vascular endothelium and the blood brain barrier may be generated. Nanoparticles having advanced qualities such as biodegradability, non-toxicity, and non-immunogenicity will facilitate the application of nanotechnology in gene therapy, leading to breakthroughs for cancer patients and in biomedical research. Formulation of unique techniques, notably using a combination of anticancer drugs, must be further researched for effective gene delivery-based therapies.

scholarly journals CUG ‐binding protein 1 ( CUGBP 1) expression and prognosis of brain metastases from non‐small cell lung cancer

2015 ◽  
Vol 7 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Xiaofei Wang ◽  
Wenjie Jiao ◽  
Yandong Zhao ◽  
Liangdong Zhang ◽  
Ruyong Yao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Binding Protein ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals PD6-1-4: Potential of therapeutic genes for small cell lung cancer gene therapy

2007 ◽  
Vol 2 (8) ◽  
pp. S425-S426
Author(s):  
Camilla L. Christensen ◽  
Nina Pedersen ◽  
Mikkel Rohde ◽  
Hans S. Poulsen
Keyword(s):  
Lung Cancer ◽  
Gene Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Gene Therapy ◽  
Small Cell ◽  
Cancer Gene ◽  
Small Cell Lung ◽  
Therapeutic Genes
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