PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability

2005 ◽  
Vol 7 (5) ◽  
pp. 604-612 ◽  
Author(s):  
Yusuke Eto ◽  
Jian-Qing Gao ◽  
Fumiko Sekiguchi ◽  
Shinnosuke Kurachi ◽  
Kazufumi Katayama ◽  
...  
Keyword(s):  
Transduction Efficiency ◽  
Rgd Peptides ◽  
High Transduction Efficiency ◽  
Adenovirus Vectors

Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob

2011 ◽  
Vol 155 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Hayato Matsui ◽  
Fuminori Sakurai ◽  
Kazufumi Katayama ◽  
Shinnosuke Kurachi ◽  
Katsuhisa Tashiro ◽  
...  
Keyword(s):  
Transduction Efficiency ◽  
Adenovirus Serotype ◽  
Rgd Peptides ◽  
Adenovirus Vectors

High Transduction Efficiency of Human Amniotic Fluid Stem Cells Mediated by Adenovirus Vectors

2008 ◽  
Vol 17 (5) ◽  
pp. 953-962 ◽  
Author(s):  
Davide Grisafi ◽  
Martina Piccoli ◽  
Michela Pozzobon ◽  
Andrea Ditadi ◽  
Patrizia Zaramella ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Transduction Efficiency ◽  
Human Amniotic Fluid ◽  
Amniotic Fluid Stem Cells ◽  
High Transduction Efficiency ◽  
Adenovirus Vectors

A Novel High Transduction Efficiency Micro Shell Resonator Gyroscope With 16 T-Shape Masses Using Out-of-Plane Electrodes

2019 ◽  
Vol 19 (13) ◽  
pp. 4820-4828 ◽  
Author(s):  
Wei Li ◽  
Xiang Xi ◽  
Kun Lu ◽  
Yan Shi ◽  
Zhanqiang Hou ◽  
...  
Keyword(s):  
Transduction Efficiency ◽  
Out Of Plane ◽  
High Transduction Efficiency

Transduction Efficiency of Adenovirus Vectors in Endothelial Cells and Vascular Smooth Muscle Cells

2020 ◽  
Vol 75 (6) ◽  
pp. 603-607
Author(s):  
Nikita Mokhashi ◽  
Robert Y. Choi ◽  
Stephanie Cicalese ◽  
Kunie Eguchi ◽  
Michael J. Boyer ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Transduction Efficiency ◽  
Adenovirus Vectors

scholarly journals Inflammation and Immune Response of Intra-Articular Serotype 2 Adeno-Associated Virus or Adenovirus Vectors in a Large Animal Model

Arthritis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Akikazu Ishihara ◽  
Jeffrey S. Bartlett ◽  
Alicia L. Bertone
Keyword(s):  
Joint Inflammation ◽  
Joint Fluid ◽  
Transduction Efficiency ◽  
Large Animal ◽  
Synovial Cells ◽  
Gene Transduction ◽  
Adeno Associated Virus ◽  
Adenovirus Vectors

Intra-articular gene therapy has potential for the treatment of osteoarthritis and rheumatoid arthritis. To quantify in vitro relative gene transduction, equine chondrocytes and synovial cells were treated with adenovirus vectors (Ad), serotype 2 adeno-associated virus vectors (rAAV2), or self-complementary (sc) AAV2 vectors carrying green fluorescent protein (GFP). Using 6 horses, bilateral metacarpophalangeal joints were injected with Ad, rAAV2, or scAAV2 vectors carrying GFP genes to assess the in vivo joint inflammation and neutralizing antibody (NAb) titer in serum and joint fluid. In vitro, the greater transduction efficiency and sustained gene expression were achieved by scAAV2 compared to rAAV2 in equine chondrocytes and synovial cells. In vivo, AAV2 demonstrated less joint inflammation than Ad, but similar NAb titer. The scAAV2 vectors can induce superior gene transduction than rAAV2 in articular cells, and both rAAV2 and scAAV2 vectors were showed to be safer for intra-articular use than Ad vectors.

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