PlncRNA‐1 stimulates hair follicle stem cell differentiation in wound healing via the EZH2/ZEB1/MAPK1 axis

2022 ◽  
Author(s):  
Fangcao Jin ◽  
Min Li ◽  
Xuyang Li ◽  
Yunpeng Zheng ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Hair Follicle ◽  
Stem Cell Differentiation ◽  
Hair Follicle Stem Cell

scholarly journals Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

Immunity ◽  
2019 ◽  
Vol 50 (3) ◽  
pp. 655-667.e4 ◽  
Author(s):  
Anubhav N. Mathur ◽  
Bahar Zirak ◽  
Ian C. Boothby ◽  
Madge Tan ◽  
Jarish N. Cohen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Hair Follicle ◽  
Treg Cell ◽  
Skin Barrier ◽  
Stem Cell Differentiation ◽  
Cell Control ◽  
Hair Follicle Stem Cell ◽  
Barrier Repair ◽  
Skin Barrier Repair

scholarly journals Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate

2020 ◽  
Author(s):  
Kira Allmeroth ◽  
Christine S. Kim ◽  
Andrea Annibal ◽  
Andromachi Pouikli ◽  
Carlos Andrés Chacón-Martínez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Fate ◽  
Protein Biosynthesis ◽  
Mrna Translation ◽  
Stem Cell Differentiation ◽  
List Type ◽  
Stem Cell Fate ◽  
Cell Fate Decisions ◽  
Hair Follicle Stem Cell

AbstractStem cell differentiation is accompanied by an increase in mRNA translation. The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine, and spermine that are essential for cell growth and stem cell maintenance. However, the role of polyamines as endogenous effectors of stem cell fate and whether they act through translational control remains obscure. Here, we investigated the function of polyamines in stem cell fate decisions using hair follicle stem cell (HFSC) organoids. HFSCs showed lower translation rates than progenitor cells, and a forced suppression of translation by direct targeting of the ribosome or through specific depletion of natural polyamines elevated stemness. In addition, we identified N1-acetylspermidine as a novel parallel regulator of cell fate decisions, increasing proliferation without reducing translation. Overall, this study delineates the diverse routes of polyamine metabolism-mediated regulation of stem cell fate decisions.Key PointsLow mRNA translation rates characterize hair follicle stem cell (HFSC) stateDepletion of natural polyamines enriches HFSCs via reduced translationN1-acetylspermidine promotes HFSC state without reducing translationN1-acetylspermidine expands the stem cell pool through elevated proliferation

Electrospun Polysaccharide Scaffolds: Wound Healing and Stem Cell Differentiation

2021 ◽  
pp. 1-15
Author(s):  
GU Preethi ◽  
BS Unnikrishnan ◽  
J Sreekutty ◽  
MG Archana ◽  
Mohan Deepa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation

scholarly journals Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e29999 ◽  
Author(s):  
Xiaobo Liang ◽  
Shreya Bhattacharya ◽  
Gaurav Bajaj ◽  
Gunjan Guha ◽  
Zhixing Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Markers ◽  
Cutaneous Wound Healing ◽  
Aberrant Expression ◽  
Cutaneous Wound ◽  
Cell Markers ◽  
Hair Follicle Stem Cell
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