Global Brain Delivery of Neuroligin 2 Gene Ameliorates Seizures in A Mouse Model of Epilepsy

2021 ◽  
Author(s):  
Keiji Oguro ◽  
Kuniko Shimazaki ◽  
Hidenori Yokota ◽  
Yoshiyuki Onuki ◽  
Yoshiya Murashima ◽  
...  
Keyword(s):  
Mouse Model ◽  
Brain Delivery ◽  
Global Brain

scholarly journals Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Nobuhisa Iwata ◽  
Misaki Sekiguchi ◽  
Yoshino Hattori ◽  
Akane Takahashi ◽  
Masashi Asai ◽  
...  
Keyword(s):  
Brain Delivery ◽  
Aav Vector ◽  
Global Brain

scholarly journals Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model

ASN NEURO ◽  
2019 ◽  
Vol 11 ◽  
pp. 175909141984339 ◽  
Author(s):  
Miriam S. Domowicz ◽  
Wen-Ching Chan ◽  
Patricia Claudio-Vázquez ◽  
Judith G. Henry ◽  
Christopher B. Ware ◽  
...  
Keyword(s):  
Mouse Model ◽  
Differentially Expressed Genes ◽  
Quantitative Polymerase Chain Reaction ◽  
Differentially Expressed ◽  
Neuronal Ceroid Lipofuscinoses ◽  
Brain Transcriptome ◽  
Transcriptional Changes ◽  
Gene Transcripts ◽  
End Stage ◽  
Global Brain

In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates the pathology and clinical features of the human disease, we analyzed end-stage (4 months) transcriptional changes associated with lack of TPP1 activity. Using RNA sequencing technology, Tpp1 expression changes in the forebrain/midbrain and cerebellum of 4-month-old homozygotes were compared with strain-related controls. Transcriptional changes were found in 510 and 1,550 gene transcripts in forebrain/midbrain and cerebellum, respectively, from Tpp1-deficient brain tissues when compared with age-matched controls. Analysis of the differentially expressed genes using the Ingenuity™ pathway software, revealed increased neuroinflammation activity in microglia and astrocytes that could lead to neuronal dysfunction, particularly in the cerebellum. We also observed upregulation in the production of nitric oxide and reactive oxygen species; activation of leukocyte extravasation signals and complement pathways; and downregulation of major transcription factors involved in control of circadian rhythm. Several of these expression changes were confirmed by independent quantitative polymerase chain reaction and histological analysis by mRNA in situ hybridization, which allowed for an in-depth anatomical analysis of the pathology and provided independent confirmation of at least two of the major networks affected in this model. The identification of differentially expressed genes has revealed new lines of investigation for this complex disorder that may lead to novel therapeutic targets.

scholarly journals Diffusion functional MRI reveals global brain network functional abnormalities driven by targeted local activity in a neuropsychiatric disease mouse model

NeuroImage ◽  
2020 ◽  
Vol 223 ◽  
pp. 117318
Author(s):  
Yoshifumi Abe ◽  
Norio Takata ◽  
Yuki Sakai ◽  
Hiro Taiyo Hamada ◽  
Yuichi Hiraoka ◽  
...  
Keyword(s):  
Mouse Model ◽  
Functional Mri ◽  
Brain Network ◽  
Neuropsychiatric Disease ◽  
Local Activity ◽  
Global Brain

Regenerating myofibers in tibialis anterior muscles of young ‘MDX’ mice

1987 ◽  
Vol 45 ◽  
pp. 726-727
Author(s):  
H. D. Geissinge ◽  
L.D. Rhodes
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Tibialis Anterior ◽  
Physiological Activity ◽  
Mdx Mice ◽  
Mode Of Inheritance

A recently discovered mouse model (‘mdx’) for muscular dystrophy in man may be of considerable interest, since the disease in ‘mdx’ mice is inherited by the same mode of inheritance (X-linked) as the human Duchenne (DMD) muscular dystrophy. Unlike DMD, which results in a situation in which the continual muscle destruction cannot keep up with abortive regenerative attempts of the musculature, and the sufferers of the disease die early, the disease in ‘mdx’ mice appears to be transient, and the mice do not die as a result of it. In fact, it has been reported that the severely damaged Tibialis anterior (TA) muscles of ‘mdx’ mice seem to display exceptionally good regenerative powers at 4-6 weeks, so much so, that these muscles are able to regenerate spontaneously up to their previous levels of physiological activity.

Mouse model of gastric infection with cytotoxin-expressing strain of Helicobacter pylori in studying of pathogenesis of chronic gastric ulcer

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S178-S184 ◽  
Author(s):  
PETER KONTUREK ◽  
TOMASZ BRZOZOWSKI ◽  
STANISLAW KONTUREK ◽  
ELZBIETA KARCZEWSKA ◽  
ROBERT PAJDO ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Mouse Model ◽  
Chronic Gastric Ulcer
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